Search Results - "QUADIRI TIMOUR"
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5‐Fluorouracil—Induced Tako‐Tsubo—Like Syndrome
Published in Pharmacotherapy (01-02-2011)“…Tako‐Tsubo cardiomyopathy (also known as apical ballooning syndrome) is a relatively new clinical entity characterized by reversible left ventricular…”
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2
Mexiletine differentially restores the trafficking defects caused by two brugada syndrome mutations
Published in Frontiers in pharmacology (01-01-2012)“…The human cardiac sodium channel Na(v)1.5 encoded by the SCN5A gene plays a critical role in cardiac excitability and the propagation of action potentials…”
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3
Ivabradine Induces an Increase in Ventricular Fibrillation Threshold During Acute Myocardial Ischemia: An Experimental Study
Published in Journal of cardiovascular pharmacology (01-12-2008)“…BACKGROUND:Tachycardia often facilitates ischemic ventricular fibrillation (VF). OBJECTIVE:This study assessed the impact of ivabradine (IVA), a selective…”
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4
The effects of ropivacaine at clinically relevant doses on myocardial ischemia in pigs
Published in Journal of anesthesia (20-11-2006)“…A major risk associated with bupivacaine during myocardial ischemia is ventricular fibrillation. We investigated the influence of ropivacaine on cardiac…”
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5
Fluoxetine blocks Nav1.5 channels via a mechanism similar to that of class 1 antiarrhythmics
Published in Molecular pharmacology (01-10-2014)“…The voltage-gated Nav1.5 channel is essential for the propagation of action potentials in the heart. Malfunctions of this channel are known to cause hereditary…”
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6
Determinants of Torsades de Pointes in Older Patients with Drug-Associated Long QT Syndrome: A Case-Control Study
Published in Drugs & aging (01-08-2014)“…Objective Many elderly patients are routinely exposed to drugs that may prolong the cardiac QT interval and cause Torsades de pointes (TdP). However,…”
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Electrophysiological, haemodynamic, and mitochondrial alterations induced by levobupivacaine during myocardial ischemia in a pig model: protection by lipid emulsions?
Published in Fundamental & clinical pharmacology (01-10-2015)“…Accidental intravascular or high‐dose injection of local anesthetics (LA) can result in serious, potentially life‐threatening complications. Indeed, adequate…”
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8
Chronic Oral Amiodarone but not Dronedarone Therapy Increases Ventricular Defibrillation Threshold During Acute Myocardial Ischemia in a Closed-Chest Animal Model
Published in Journal of cardiovascular pharmacology (01-06-2012)“…Dronedarone, a recently approved antiarrhythmic drug, has been shown to have fewer side effects than amiodarone, particularly with regard to thyroid and…”
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9
Ivabradine but not propranolol delays the time to onset of ischaemia-induced ventricular fibrillation by preserving myocardial metabolic energy status
Published in Resuscitation (01-03-2013)“…Abstract Objective Heart rate reduction (HRR) has shown a beneficial impact on the prevention of ventricular fibrillation, which could be explained by…”
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10
Protective effects of ranolazine and propranolol, alone or combined, on the structural and functional alterations of cardiomyocyte mitochondria in a pig model of ischemia/reperfusion
Published in Fundamental & clinical pharmacology (01-06-2014)“…Preventing the consequences of ischemia/reperfusion (I/R)‐induced lesions in the clinic requires the administration of pharmacological agents prior to…”
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11
Effects of amlodipine and perindoprilate on the structure and function of mitochondria in ventricular cardiomyocytes during ischemia-reperfusion in the pig
Published in Fundamental & clinical pharmacology (01-02-2015)“…The aim of this study was to determine whether amlodipine and/or perindoprilate injected intravenously (iv) prior to ischemia exerted protective effects on…”
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12
Vagal stimulation after acute coronary occlusion: The heart rate matters
Published in Cardiology journal (2018)“…There is a well documented causal link between autonomic imbalance and cardiac elec-trical instability. However, the mechanisms underlying the antiarrhythmic…”
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13
Heart rate reduction with ivabradine increases ischaemia-induced ventricular fibrillation threshold: Role of myocyte structure and myocardial perfusion
Published in Resuscitation (01-08-2011)“…Abstract Aims We showed previously that ivabradine (IVA), a selective inhibitor of the cardiac pacemaker I f current, achieved protection against…”
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14
Sudden death of cardiac origin and psychotropic drugs
Published in Frontiers in pharmacology (01-01-2012)“…Mortality rate is high in psychiatric patients versus general population. An important cause of this increased mortality is sudden cardiac death (SCD) as a…”
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15
Heart lesions associated with anabolic steroid abuse: Comparison of post-mortem findings in athletes and norethandrolone-induced lesions in rabbits
Published in Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie (01-07-2009)“…Among 15,000 forensic post-mortem examinations performed on the coroner's order over a 24-year period (January 1981–December 2004) in the area of Lyon, France…”
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16
Bupivacaine Hastens the Ischemia-Induced Decrease of the Electrical Ventricular Fibrillation Threshold
Published in Anesthesia and analgesia (01-04-1995)“…Myocardial ischemia sensitizes the cardiotoxic effects of bupivacaine, especially the propensity to ventricular fibrillation.To investigate this sensitization…”
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17
Experimental intracameral injection of vancomycin microparticles in rabbits
Published in Investigative ophthalmology & visual science (01-08-2010)“…To evaluate the in vivo toxicity and efficacy of previously developed poly-(lactide-co-glycolide)-vancomycin-based microparticles (V-MPLs) for eventual use for…”
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18
The antiarrhythmic effect of vagal stimulation after acute coronary occlusion: Role of the heart rate
Published in Cardiology journal (02-01-2013)Get full text
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19
Involvement of neuroleptic drugs in selenium deficiency and sudden death of cardiac origin: Study and human post-mortem examination
Published in Journal of trace elements in medicine and biology (01-06-2012)“…The involvement of psychotropic drugs in sudden deaths has been highlighted. The objective of this work was to establish a link between selenium levels in…”
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20
Cardiac Lesions Induced by Testosterone: Protective Effects of Dexrazoxane and Trimetazidine
Published in Cardiovascular toxicology (01-06-2009)“…Further to our previous observation of post-mortem cardiac lesions after sudden death in several athletes with a history of anabolic steroid abuse, this study…”
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