Search Results - "QINGHUI OU"

Transient Cell Cycle Induction in Cardiomyocytes to Treat Subacute Ischemic Heart Failure by Abouleisa, Riham R.E., Salama, Abou Bakr M., Ou, Qinghui, Tang, Xian-Liang, Solanki, Mitesh, Guo, Yiru, Nong, Yibing, McNally, Lindsey, Lorkiewicz, Pawel K., Kassem, Kamal M., Ahern, Brooke M., Choudhary, Krishna, Thomas, Reuben, Huang, Yu, Juhardeen, Hamzah R., Siddique, Aisha, Ifthikar, Zainab, Hammad, Sally K., Elbaz, Ayman S., Ivey, Kathryn N., Conklin, Daniel J., Satin, Jonathan, Hill, Bradford G., Srivastava, Deepak, Bolli, Roberto, Mohamed, Tamer M.A.

“…The regenerative capacity of the heart after myocardial infarction is limited. Our previous study showed that ectopic introduction of 4 cell cycle factors (4F;…”
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Repeated Administrations of Cardiac Progenitor Cells Are Superior to a Single Administration of an Equivalent Cumulative Dose by Tang, Xian‐Liang, Nakamura, Shunichi, Li, Qianhong, Wysoczynski, Marcin, Gumpert, Anna M., Wu, Wen‐Jian, Hunt, Greg, Stowers, Heather, Ou, Qinghui, Bolli, Roberto

“…Background We have recently found that 3 repeated doses (12×106 each) of c‐kitPOS cardiac progenitor cells (CPCs) were markedly more effective than a single…”
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Intracoronary administration of cardiac stem cells in mice: a new, improved technique for cell therapy in murine models by Li, Qianhong, Guo, Yiru, Ou, Qinghui, Chen, Ning, Wu, Wen-Jian, Yuan, Fangping, O’Brien, Erin, Wang, Tao, Luo, Li, Hunt, Gregory N., Zhu, Xiaoping, Bolli, Roberto

“…A model of intracoronary stem cell delivery that enables transgenesis/gene targeting would be a powerful tool but is still lacking. To address this gap, we…”
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Cell cycle induction in human cardiomyocytes is dependent on biosynthetic pathway activation by Abouleisa, Riham R.E., McNally, Lindsey, Salama, Abou bakr M., Hammad, Sally K., Ou, Qinghui, Wells, Collin, Lorkiewicz, Pawel K., Bolli, Roberto, Mohamed, Tamer M.A., Hill, Bradford G.

“…The coordinated gene and metabolic programs that facilitate cardiomyocyte entry and progression in the cell cycle are poorly understood. The purpose of this…”
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Artificial Intelligence Based Framework to Quantify the Cardiomyocyte Structural Integrity in Heart Slices by Abdeltawab, Hisham, Khalifa, Fahmi, Hammouda, Kamal, Miller, Jessica M., Meki, Moustafa M., Ou, Qinghui, El-Baz, Ayman, Mohamed, Tamer M. A.

“…Purpose Drug induced cardiac toxicity is a disruption of the functionality of cardiomyocytes which is highly correlated to the organization of the subcellular…”
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FGF21/FGFR1-β-KL cascade in cardiomyocytes modulates angiogenesis and inflammation under metabolic stress by Kaur, Namrita, Gare, Sanskruti Ravindra, Ruiz-Velasco, Andrea, Miller, Jessica M., Abouleisa, Riham R.E., Ou, Qinghui, Shen, Jiahan, Soran, Handrean, Mohamed, Tamer M.A., Liu, Wei

“…Diabetes is a metabolic disorder with an increased risk of developing heart failure. Inflammation and damaged vasculature are the cardinal features of…”
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Biomimetic cardiac tissue culture model (CTCM) to emulate cardiac physiology and pathophysiology ex vivo by Miller, Jessica M., Meki, Moustafa H., Elnakib, Ahmed, Ou, Qinghui, Abouleisa, Riham R. E., Tang, Xian-Liang, Salama, Abou Bakr M., Gebreil, Ahmad, Lin, Cindy, Abdeltawab, Hisham, Khalifa, Fahmi, Hill, Bradford G., Abi-Gerges, Najah, Bolli, Roberto, El-Baz, Ayman S., Giridharan, Guruprasad A., Mohamed, Tamer M. A.

“…There is need for a reliable in vitro system that can accurately replicate the cardiac physiological environment for drug testing. The limited availability of…”
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Repeated Administrations of Cardiac Progenitor Cells Are Markedly More Effective Than a Single Administration by Tokita, Yukichi, Tang, Xian-Liang, Li, Qianhong, Wysoczynski, Marcin, Hong, Kyung U, Nakamura, Shunichi, Wu, Wen-Jian, Xie, Wei, Li, Ding, Hunt, Greg, Ou, Qinghui, Stowers, Heather, Bolli, Roberto

“…Rationale:The effects of c-kitPOS cardiac progenitor cells (CPCs, and adult cell therapy in general) on left ventricular (LV) function have been regarded as…”
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Gene Transfer of Inducible Nitric Oxide Synthase Affords Cardioprotection by Upregulating Heme Oxygenase-1 Via a Nuclear Factor-κB-Dependent Pathway by QIANHONG LI, YIRU GUO, SHINMURA, Ken, ROKOSH, Gregg D, SHUYAN WANG, BOLLI, Roberto, QINGHUI OU, CHUANJUE CUI, WU, Wen-Jian, WEI TAN, XIAOPING ZHU, LANCETA, Lilibeth B, SANGANALMATH, Santosh K, DAWN, Buddhadeb

“…Background— Although inducible nitric oxide synthase (iNOS) is known to impart powerful protection against myocardial infarction, the mechanism for this…”
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Cardioprotection afforded by inducible nitric oxide synthase gene therapy is mediated by cyclooxygenase-2 via a nuclear factor-κB-dependent pathway by QIANHONG LI, YIRU GUO, WEI TAN, QINGHUI OU, WU, Wen-Jian, STURZA, Diana, DAWN, Buddhadeb, HUNT, Greg, CHUANJUE CUI, BOLLI, Roberto

“…Background— Gene therapy with inducible nitric oxide synthase (iNOS) markedly reduces myocardial infarct size; this effect is associated with cyclooxygenase-2…”
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Restored autophagy is protective against PAK3-induced cardiac dysfunction by Ruiz-Velasco, Andrea, Raja, Rida, Chen, Xinyi, Ganenthiran, Haresh, Kaur, Namrita, Alatawi, Nasser hawimel o, Miller, Jessica M., Abouleisa, Riham R.E., Ou, Qinghui, Zhao, Xiangjun, Fonseka, Oveena, Wang, Xin, Hille, Susanne S., Frey, Norbert, Wang, Tao, Mohamed, Tamer M.A., Müller, Oliver J., Cartwright, Elizabeth J., Liu, Wei

“…Despite the development of clinical treatments, heart failure remains the leading cause of mortality. We observed that p21-activated kinase 3 (PAK3) was…”
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Paracrine signal emanating from stressed cardiomyocytes aggravates inflammatory microenvironment in diabetic cardiomyopathy by Kaur, Namrita, Ruiz-Velasco, Andrea, Raja, Rida, Howell, Gareth, Miller, Jessica M., Abouleisa, Riham R.E., Ou, Qinghui, Mace, Kimberly, Hille, Susanne S., Frey, Norbert, Binder, Pablo, Smith, Craig P., Fachim, Helene, Soran, Handrean, Swanton, Eileithyia, Mohamed, Tamer M.A., Müller, Oliver J., Wang, Xin, Chernoff, Jonathan, Cartwright, Elizabeth J., Liu, Wei

“…Myocardial inflammation contributes to cardiomyopathy in diabetic patients through incompletely defined underlying mechanisms. In both human and time-course…”
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Long-Term Outcome of Administration of c-kit(POS) Cardiac Progenitor Cells After Acute Myocardial Infarction: Transplanted Cells Do not Become Cardiomyocytes, but Structural and Functional Improvement and Proliferation of Endogenous Cells Persist for at Least One Year by Tang, Xian-Liang, Li, Qianhong, Rokosh, Gregg, Sanganalmath, Santosh K, Chen, Ning, Ou, Qinghui, Stowers, Heather, Hunt, Greg, Bolli, Roberto

“…Cardiac progenitor cells (CPCs) improve left ventricular remodeling and function after acute or chronic myocardial infarction. However, the long-term (>5…”
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PU.1 inhibition does not attenuate cardiac function deterioration or fibrosis in a murine model of myocardial infarction by Nong, Yibing, Guo, Yiru, Ou, Qinghui, Gumpert, Anna, Tomlin, Alex, Zhu, Xiaoping, Bolli, Roberto

“…Activated cardiac fibroblasts are involved in both reparative wound healing and maladaptive cardiac fibrosis after myocardial infarction (MI). Recent evidence…”
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Repeated Administrations of Cardiac Progenitor Cells Are Markedly More Effective Than a Single Administration: A New Paradigm in Cell Therapy by Tokita, Yukichi, Tang, Xian-Liang, Li, Qianhong, Wysoczynski, Marcin, Hong, Kyung U, Nakamura, Shunichi, Wu, Wen-Jian, Xie, Wei, Li, Ding, Hunt, Greg, Ou, Qinghui, Stowers, Heather, Bolli, Roberto

“…RATIONALE:The effects of c-kit cardiac progenitor cells (CPCs, and adult cell therapy in general) on left ventricular (LV) function have been regarded as…”
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Abstract P337: CD36 Is Required To Prime Cardiomyocytes For Proliferation by Salama, Aboubakr M, Abouleisa, Riham, Ou, Qinghui, Gibreil, Ahmed, Mohamed, Tamer

“…Many approaches have been explored to regenerate the heart muscle followingischemic injury, out of which is the induction of cardiomyocytes proliferation…”
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Abstract P1014: Cardiomyocyte Energetic Capacity Governs Responses To Cell Cycle Stimulation by Salama, Abou bakr M, Ou, Qinghui, Abouleisa, Riham, Mohamed, Tamer, Hill, Bradford G, Gebreil, Ahmad, Wells, Collin

“…BackgroundInduction of cardiomyocyte (CM) proliferation is a promising strategy for cardiac regeneration. We previously showed that the overexpression of four…”
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Abstract P1029: Improving Cardiomyocyte Cell Cycle Entry In Response To Direct Cell Cycle Stimulation Using A Novel Small Molecule Inhibitor Of P38 by Abouleisa, Riham R, Gebreil, Ahmad, Salama, Aboubakr B, Ou, Qinghui, Abo-Dya, Nader E, Hill, Bradford G, Mohamed, Tamer

“…BackgroundMyocardial infarction is the leading cause of mortality globally, due in part to the limited ability of cardiomyocytes (CMs) to regenerate. Recently,…”
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Abstract P1076: Rrad Regulates Cardiomyocyte Cell Cycle Entry By Modulating Calcineurin Activity by Devilee, Lynn, Miller, Jessica, Ou, Qinghui, Salama, Abou Bakr M, andres, douglas, Satin, Jonathan, Mohamed, Tamer, Hudson, James E, Abouleisa, Riham

“…Abstract only Background: Cardiomyocytes (CMs) lost during ischemic cardiac injury cannot be replaced due to their limited proliferative capacity, which leads…”
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Abstract P1087: Cd36-retinoic Acid-PPARδ Signaling Axis Modulates Cardiomyocytes’ Ability To Proliferate In Newly Born Neonatal Mice by Salama, Abou Bakr M, Abouleisa, Riham, Ou, Qinghui, Miller, Jessica, Dwenger, Marc, Gebreil, Ahmad, abdelhafez, Hania, Arai, Momo, Abdulwali, Sameeha, Almasry, yazan, Hill, Bradford G, Mohamed, Tamer

“…Abstract only Background: A pertinent question is why only a subset of fetal/neonatal cardiomyocytes (CMs) spontaneously proliferate. Using single-cell RNAseq,…”
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