Search Results - "QIN JIANG"

STAT3 as a potential therapeutic target in triple negative breast cancer: a systematic review by Qin, Jiang-Jiang, Yan, Li, Zhang, Jia, Zhang, Wei-Dong

“…Triple negative breast cancer (TNBC), which is typically lack of expression of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth…”
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Targeting KRAS mutant cancers: from druggable therapy to drug resistance by Zhu, Chunxiao, Guan, Xiaoqing, Zhang, Xinuo, Luan, Xin, Song, Zhengbo, Cheng, Xiangdong, Zhang, Weidong, Qin, Jiang-Jiang

“…Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS) is the most frequently mutated oncogene, occurring in a variety of tumor types. Targeting KRAS mutations with…”
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Long non-coding RNAs towards precision medicine in gastric cancer: early diagnosis, treatment, and drug resistance by Yuan, Li, Xu, Zhi-Yuan, Ruan, Shan-Ming, Mo, Shaowei, Qin, Jiang-Jiang, Cheng, Xiang-Dong

“…Gastric cancer is a deadly disease and remains the third leading cause of cancer-related death worldwide. The 5-year overall survival rate of patients with…”
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Targeting ferroptosis in gastric cancer: Strategies and opportunities by Le, Jiahan, Pan, Guangzhao, Zhang, Che, Chen, Yitao, Tiwari, Amit K., Qin, Jiang‐Jiang

“…Summary Ferroptosis is a novel form of programmed cell death morphologically, genetically, and biochemically distinct from other cell death pathways and…”
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Targeting MDM2 for novel molecular therapy: Beyond oncology by Wang, Wei, Qin, Jiang‐Jiang, Rajaei, Mehrdad, Li, Xin, Yu, Xiaoyi, Hunt, Courtney, Zhang, Ruiwen

“…The murine double minute 2 (MDM2) oncogene exerts major oncogenic activities in human cancers; it is not only the best‐documented negative regulator of the p53…”
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Protein degradation technology: a strategic paradigm shift in drug discovery by Li, Haobin, Dong, Jinyun, Cai, Maohua, Xu, Zhiyuan, Cheng, Xiang-Dong, Qin, Jiang-Jiang

“…Targeting pathogenic proteins with small-molecule inhibitors (SMIs) has become a widely used strategy for treating malignant tumors. However, most…”
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Dual roles and therapeutic potential of Keap1-Nrf2 pathway in pancreatic cancer: a systematic review by Qin, Jiang-Jiang, Cheng, Xiang-Dong, Zhang, Jia, Zhang, Wei-Dong

“…Pancreatic cancer (PC) is one of the most fatal diseases with a very high rate of metastasis and low rate of survival. Despite the advances in understanding…”
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Strategies to overcome cancer multidrug resistance (MDR) through targeting P-glycoprotein (ABCB1): An updated review by Dong, Jinyun, Yuan, Li, Hu, Can, Cheng, Xiangdong, Qin, Jiang-Jiang

“…The emergence of multidrug resistance (MDR) in malignant tumors is one of the leading threats encountered currently in many chemotherapeutic agents. The…”
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PROTAC: An Effective Targeted Protein Degradation Strategy for Cancer Therapy by Qi, Si-Min, Dong, Jinyun, Xu, Zhi-Yuan, Cheng, Xiang-Dong, Zhang, Wei-Dong, Qin, Jiang-Jiang

“…Proteolysis targeting chimeric (PROTAC) technology is an effective endogenous protein degradation tool developed in recent years that can ubiquitinate the…”
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Platelet Membrane‐Camouflaged Magnetic Nanoparticles for Ferroptosis‐Enhanced Cancer Immunotherapy by Jiang, Qin, Wang, Kuang, Zhang, Xingyu, Ouyang, Boshu, Liu, Haixia, Pang, Zhiqing, Yang, Wuli

“…Although cancer immunotherapy has emerged as a tremendously promising cancer therapy method, it remains effective only for several cancers. Photoimmunotherapy…”
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Recent Update on Development of Small-Molecule STAT3 Inhibitors for Cancer Therapy: From Phosphorylation Inhibition to Protein Degradation by Dong, Jinyun, Cheng, Xiang-Dong, Zhang, Wei-Dong, Qin, Jiang-Jiang

“…Signal transducer and activator of transcription 3 (STAT3) is a transcription factor that regulates various biological processes, including proliferation,…”
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Polycomb Group (PcG) Proteins and Human Cancers: Multifaceted Functions and Therapeutic Implications by Wang, Wei, Qin, Jiang-Jiang, Voruganti, Sukesh, Nag, Subhasree, Zhou, Jianwei, Zhang, Ruiwen

“…Polycomb group (PcG) proteins are transcriptional repressors that regulate several crucial developmental and physiological processes in the cell. More…”
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Size-Controlled Synthesis of Porphyrinic Metal–Organic Framework and Functionalization for Targeted Photodynamic Therapy by Park, Jihye, Jiang, Qin, Feng, Dawei, Mao, Lanqun, Zhou, Hong-Cai

“…The understanding of nanomaterials for targeted cancer therapy is of great importance as physical parameters of nanomaterials have been shown to be strong…”
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Lateral Resistant Behavior of Grid-Reinforced Steel Corrugated Shear Walls by Dou, Chao, Ru, Yi, Jiang, Zi-Qin, Wang, Yan

“…AbstractThis paper investigated the lateral resistant behavior of grid-reinforced steel corrugated shear walls (GR-SCSWs), which are applied to shear walls…”
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Research progress on antitumor mechanisms and molecular targets of Inula sesquiterpene lactones by Cao, Fei, Chu, Chu, Qin, Jiang-Jiang, Guan, Xiaoqing

“…The pharmacological effects of natural product therapy have received sigificant attention, among which terpenoids such as sesquiterpene lactones stand out due…”
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CausalCD: A Causal Graph Contrastive Learning Framework for Self-Supervised SAR Image Change Detection by Li, Haolin, Zou, Bin, Zhang, Lamei, Qin, Jiang

“…In recent years, self-supervised synthetic aperture radar (SAR) image change detection methods have achieved remarkable results, particularly in reducing…”
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The association between severe COVID‐19 and low platelet count: evidence from 31 observational studies involving 7613 participants by Jiang, Shi‐Qin, Huang, Qiu‐Fen, Xie, Wei‐Ming, Lv, Chao, Quan, Xiao‐Qing

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Role of F-box proteins in human upper gastrointestinal tumors by Zhang, Che, Pan, Guangzhao, Qin, Jiang-Jiang

“…Protein ubiquitination and degradation is an essential physiological process in almost all organisms. As the key participants in this process, the E3 ubiquitin…”
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Characterization of a bioactive meroterpenoid isolated from the marine-derived fungus Talaromyces sp by Hong, Xuan, Guan, Xiaoqing, Lai, Qiliang, Yu, Dehua, Chen, Zhongwei, Fu, Xiaoteng, Zhang, Beibei, Chen, Changkun, Shao, Zongze, Xia, Jinmei, Qin, Jiang-Jiang, Wang, Weiyi

“…A new meroterpenoid, taladrimanin A ( 1 ), was isolated from a marine-derived fungus Talaromyces sp. HM6-1–1, together with eleven biogenetically related…”
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Vehicle Detection Based on Semantic-Context Enhancement for High-Resolution SAR Images in Complex Background by Zou, Bin, Qin, Jiang, Zhang, Lamei

“…Small-scale target detection (such as vehicles) in complex synthetic aperture radar (SAR) image scenes has always been a pain point for the advanced…”
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