Search Results - "QI, Weier"

Pyruvate kinase M2 activation may protect against the progression of diabetic glomerular pathology and mitochondrial dysfunction by Qi, Weier, Keenan, Hillary A, Li, Qian, Ishikado, Atsushi, Kannt, Aimo, Sadowski, Thorsten, Yorek, Mark A, Wu, I-Hsien, Lockhart, Samuel, Coppey, Lawrence J, Pfenninger, Anja, Liew, Chong Wee, Qiang, Guifen, Burkart, Alison M, Hastings, Stephanie, Pober, David, Cahill, Christopher, Niewczas, Monika A, Israelsen, William J, Tinsley, Liane, Stillman, Isaac E, Amenta, Peter S, Feener, Edward P, Vander Heiden, Matthew G, Stanton, Robert C, King, George L

“…Studying patients with long-term diabetes who lack diabetic nephropathy reveals that targeting pyruvate kinase M2 protects against renal disease. Diabetic…”
Get full text

Preservation of renal function in chronic diabetes by enhancing glomerular glucose metabolism by Qi, Weier, Li, Qian, Gordin, Daniel, King, George L.

“…Diabetic nephropathy (DN) affects approximately 30–40% of patients with type 1 (T1DM) and type 2 diabetes (T2DM). It is a major cause of end-stage renal…”
Get full text

Characterization of Glycolytic Enzymes and Pyruvate Kinase M2 in Type 1 and 2 Diabetic Nephropathy by Gordin, Daniel, Shah, Hetal, Shinjo, Takanori, St-Louis, Ronald, Qi, Weier, Park, Kyoungmin, Paniagua, Samantha M, Pober, David M, Wu, I-Hsien, Bahnam, Vanessa, Brissett, Megan J, Tinsley, Liane J, Dreyfuss, Jonathan M, Pan, Hui, Dong, Yutong, Niewczas, Monika A, Amenta, Peter, Sadowski, Thorsten, Kannt, Aimo, Keenan, Hillary A, King, George L

“…Elevated glycolytic enzymes in renal glomeruli correlated with preservation of renal function in the Medalist Study, individuals with ≥50 years of type 1…”
Get full text

Homozygous receptors for insulin and not IGF-1 accelerate intimal hyperplasia in insulin resistance and diabetes by Li, Qian, Fu, Jialin, Xia, Yu, Qi, Weier, Ishikado, Atsushi, Park, Kyoungmin, Yokomizo, Hisashi, Huang, Qian, Cai, Weikang, Rask-Madsen, Christian, Kahn, C. Ronald, King, George L.

“…Insulin and IGF-1 actions in vascular smooth muscle cells (VSMC) are associated with accelerated arterial intima hyperplasia and restenosis after angioplasty,…”
Get full text

Regulation of Macrophage Apoptosis and Atherosclerosis by Lipid-Induced PKCδ Isoform Activation by Li, Qian, Park, Kyoungmin, Xia, Yu, Matsumoto, Motonobu, Qi, Weier, Fu, Jialin, Yokomizo, Hisashi, Khamaisi, Mogher, Wang, Xuanchun, Rask-Madsen, Christian, King, George L

“…Activation of monocytes/macrophages by hyperlipidemia associated with diabetes mellitus and obesity contributes to the development of atherosclerosis. PKCδ…”
Get full text

Implications of Treatment That Target Protective Mechanisms Against Diabetic Nephropathy by Mima, Akira, MD, PhD, Qi, Weier, PhD, King, George L., MD

“…Summary Diabetes results in vascular changes and dysfunction, and vascular complications are the leading cause of morbidity and mortality in diabetic patients…”
Get full text

Expression, Localization, and Function of the Thioredoxin System in Diabetic Nephropathy by ADVANI, Andrew, GILBERT, Richard E, POLLOCK, Carol A, QI, Weier, SIH MIN TAN, PARVING, Hans-Henrik, KELLY, Darren J, THAI, Kerri, GOW, Renae M, LANGHAM, Robyn G, COX, Alison J, CONNELLY, Kim A, YUAN ZHANG, HERZENBERG, Andrew M, CHRISTENSEN, Per Knud

“…Excessive reactive oxygen species play a key role in the pathogenesis of diabetic nephropathy, but to what extent these result from increased generation,…”
Get full text

Transcription Factors Krüppel-Like Factor 6 and Peroxisome Proliferator-Activated Receptor-γ Mediate High Glucose-Induced Thioredoxin-Interacting Protein by Qi, Weier, Chen, Xinming, Holian, John, Tan, Christina Y.R, Kelly, Darren J, Pollock, Carol A

“…We demonstrated recently that thioredoxin-interacting protein (Txnip) and the transcription factor Krüppel-like factor 6 (KLF6) were up-regulated in both in…”
Get full text

The renal cortical fibroblast in renal tubulointerstitial fibrosis by Qi, Weier, Chen, Xinming, Poronnik, Philip, Pollock, Carol A.

“…Renal cortical fibroblasts have key roles in mediating intercellular communication with neighboring/infiltrating cells and extracellular matrix (ECM) and…”
Get full text

Thioredoxin-interacting protein: a potential therapeutic target for treatment of progressive fibrosis in diabetic nephropathy by Tan, Christina Y R, Weier, Qi, Zhang, Yuan, Cox, Alison J, Kelly, Darren J, Langham, Robyn G

“…Thioredoxin-interacting protein (TXNIP) is an endogenous inhibitor of the antioxidant thioredoxin, and a critical agent in the in vivo regulation of glucose…”
Get more information

Tranilast attenuates the up-regulation of thioredoxin-interacting protein and oxidative stress in an experimental model of diabetic nephropathy by SIH MIN TAN, YUAN ZHANG, COX, Alison J, KELLY, Darren J, WEIER QI

“…Diabetic nephropathy is the leading cause of kidney failure in the developed world. Tranilast has been reported to not only act as an anti-inflammatory and…”
Get full text

High Glucose-Induced Thioredoxin-Interacting Protein in Renal Proximal Tubule Cells Is Independent of Transforming Growth Factor-β1 by Qi, Weier, Chen, Xinming, Gilbert, Richard E, Zhang, Yuan, Waltham, Mark, Schache, Maria, Kelly, Darren J, Pollock, Carol A

“…Hyperglycemia is a causative factor in the pathogenesis of diabetic nephropathy. Here, we demonstrate the transcriptional profiles of the human proximal tubule…”
Get full text

3',4'-Dihydroxyflavonol antioxidant attenuates diastolic dysfunction and cardiac remodeling in streptozotocin-induced diabetic m(Ren2)27 rats by Khong, Fay Lin, Zhang, Yuan, Edgley, Amanda J, Qi, Weier, Connelly, Kim A, Woodman, Owen L, Krum, Henry, Kelly, Darren J

“…Diabetic cardiomyopathy (DCM) is an increasingly recognized cause of chronic heart failure amongst diabetic patients. Both increased reactive oxygen species…”
Get full text

Ramipril retards development of aortic valve stenosis in a rabbit model: mechanistic considerations by Ngo, Doan TM, Stafford, Irene, Sverdlov, Aaron L, Qi, Weier, Wuttke, Ronald D, Zhang, Yuan, Kelly, Darren J, Weedon, Helen, Smith, Malcolm D, Kennedy, Jennifer A, Horowitz, John D

“…BACKGROUND AND PURPOSE Aortic valve stenosis (AVS) is associated with significant cardiovascular morbidity and mortality. To date, no therapeutic modality has…”
Get full text

1705-P: Obesity Phenotype Exhibit Differential Signatures of Circulating Biomarkers with Susceptible Obesity-Related Comorbidities by Qi, Weier, Tu, Xiao, Robertson, Darren, Acosta, Andres, Parker, Victoria E

“…Background: Obesity is a heterogeneous disease with different phenotypes based on physiological and biological differences in energy intake and expenditure. A…”
Get full text

Treatment Response of Cotadutide a Dual GLP-1 Glucagon Receptor Agonist in Obesity Phenotypes by Tu, Xiao, Qi, Weier, Robertson, Darren, Hansen, Lars, Chang, Yi-Ting, Parker, Victoria

Get full text

Metabolic Profiles in Different Obesity Phenotypes by Qi, Weier, Tu, Xiao, Robertson, Darren, Hansen, Lars, Chang, Yi-Ting, Parker, Victoria

“…Background: Obesity is a heterogeneous disease with different phenotypes based on physiological and biological differences in energy intake and expenditure. A…”
Get full text

Induction of Vascular Insulin Resistance and Endothelin-1 Expression and Acceleration of Atherosclerosis by the Overexpression of Protein Kinase C-β Isoform in the Endothelium by Li, Qian, Park, Kyoungmin, Li, Chenzhong, Rask-Madsen, Christian, Mima, Akira, Qi, Weier, Mizutani, Koji, Huang, Paul, King, George L

“…RATIONALE:Loss of insulin action in the endothelium can cause endothelial dysfunction and atherosclerosis. Hyperglycemia and elevated fatty acids induced by…”
Get full text

PKCδ inhibition normalizes the wound-healing capacity of diabetic human fibroblasts by Khamaisi, Mogher, Katagiri, Sayaka, Keenan, Hillary, Park, Kyoungmin, Maeda, Yasutaka, Li, Qian, Qi, Weier, Thomou, Thomas, Eschuk, Danielle, Tellechea, Ana, Veves, Aris, Huang, Chenyu, Orgill, Dennis Paul, Wagers, Amy, King, George L

“…Abnormal fibroblast function underlies poor wound healing in patients with diabetes; however, the mechanisms that impair wound healing are poorly defined…”
Get full text

PKC[delta] inhibition normalizes the wound-healing capacity of diabetic human fibroblasts by Khamaisi, Mogher, Katagiri, Sayaka, Keenan, Hillary, Park, Kyoungmin, Maeda, Yasutaka, Li, Qian, Qi, Weier, Thomou, Thomas, Eschuk, Danielle, Tellechea, Ana, Veves, Aris, Huang, Chenyu, Orgill, Dennis Paul, Wagers, Amy, King, George L

“…Abnormal fibroblast function underlies poor wound healing in patients with diabetes; however, the mechanisms that impair wound healing are poorly defined…”
Get full text