Search Results - "Pype, Casper"

Xenobiotic metabolism in the zebrafish: a review of the spatiotemporal distribution, modulation and activity of Cytochrome P450 families 1 to 3 by Saad, Moayad, Cavanaugh, Kate, Verbueken, Evy, Pype, Casper, Casteleyn, Christophe, Ginneken, Chris Van, Cruchten, Steven Van

“…The zebrafish (Danio rerio) has been increasingly explored in pharmaceutical research as a promising alternative model for toxicological screens. This…”
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In vitro CYP-mediated drug metabolism in the zebrafish (embryo) using human reference compounds by Saad, Moayad, Matheeussen, An, Bijttebier, Sebastiaan, Verbueken, Evy, Pype, Casper, Casteleyn, Christophe, Van Ginneken, Chris, Apers, Sandra, Maes, Louis, Cos, Paul, Van Cruchten, Steven

“…The increasing use of zebrafish embryos as an alternative model for toxicological and pharmacological studies necessitates a better understanding of xenobiotic…”
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Incubation at 32.5°C and above causes malformations in the zebrafish embryo by Pype, Casper, Verbueken, Evy, Saad, Moayad A., Casteleyn, Christophe R., Van Ginneken, Chris J., Knapen, Dries, Van Cruchten, Steven J.

“…Zebrafish embryos are increasingly used for developmental toxicity screening of candidate drugs and are occasionally co-incubated with a metabolic activation…”
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Effect of TNBS-induced colitis on enteric neuronal subpopulations in adult zebrafish by Uyttebroek, Leen, Pype, Casper, Hubens, Guy, Timmermans, Jean-Pierre, Van Nassauw, Luc

“…Inflammatory bowel disease (IBD) includes inflammation of the gastrointestinal (GI) tract and is characterized by periods of acute inflammation and remission…”
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In vitro CYP1A activity in the zebrafish: temporal but low metabolite levels during organogenesis and lack of gender differences in the adult stage by Saad, Moayad, Verbueken, Evy, Pype, Casper, Casteleyn, Christophe, Van Ginneken, Chris, Maes, Louis, Cos, Paul, Van Cruchten, Steven

“…The zebrafish (Danio rerio) is increasingly used as a screening model for acute, chronic and developmental toxicity. More specifically, the embryo is currently…”
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In Vitro Biotransformation of Two Human CYP3A Probe Substrates and Their Inhibition during Early Zebrafish Development by Verbueken, Evy, Alsop, Derek, Saad, Moayad A, Pype, Casper, Van Peer, Els M, Casteleyn, Christophe R, Van Ginneken, Chris J, Wilson, Joanna, Van Cruchten, Steven J

“…At present, the zebrafish embryo is increasingly used as an alternative animal model to screen for developmental toxicity after exposure to xenobiotics. Since…”
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Refinement of the zebrafish embryo developmental toxicity assay by Hoyberghs, Jente, Bars, Chloé, Pype, Casper, Foubert, Kenn, Ayuso Hernando, Miriam, Van Ginneken, Chris, Ball, Jonathan, Van Cruchten, Steven

“…Several pharmaceutical and chemical companies are using the zebrafish embryo as an alternative to animal testing for early detection of developmental…”
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UPLC/MS MS data of testosterone metabolites in human and zebrafish liver microsomes and whole zebrafish larval microsomes by Saad, Moayad, Bijttebier, Sebastiaan, Matheeussen, An, Verbueken, Evy, Pype, Casper, Casteleyn, Christophe, Van Ginneken, Chris, Maes, Louis, Cos, Paul, Van Cruchten, Steven

“…This article represents data regarding a study published in Toxicology in vitro entitled “ in vitro CYP-mediated drug metabolism in the zebrafish (embryo)…”
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From coincubation to preincubation: Strategy adjustments in the mDarT by Pype, Casper, Verbueken, Evy, Bars, Chloé, Van Ginneken, Chris J., Knapen, Dries, Van Cruchten, Steven J.

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Localization of cytochrome P450 activity in the zebrafish embryo and larva by Verbueken, Evy, Pype, Casper, Bars, Chloé, Van Ginneken Chris, J., Van Cruchten Steven, J.

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Co-incubation with liver microsomes in the mDarT, a bridge too far? by Pype, Casper, Verbueken, Evy, Bars, Chloé, Van Ginneken, Chris J., Knapen, Dries, Van Cruchten, Steven J.

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Localization of cytochrome P450 activity in the zebrafish embryo and larva by Verbueken, Evy, Bars, Chloé, Pype, Casper, Marei, Waleed F.A., Bols, Peter E.J., Van Ginneken, Chris J., Van Cruchten, Steven J.

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In vitro metabolism of mammalian proteratogens in the zebrafish: A preliminary investigation by Bars, Chloé, Bijttebier, Sebastiaan, Pype, Casper, Verbueken, Evy, Saad, Moayad, Van Ginneken, Chris J., Van Cruchten, Steven J.

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In vitro characterization and ontogeny of CYP3A activity in the zebrafish by Verbueken, Evy, Saad, Moayad A., Pype, Casper, Casteleyn, Christophe, Van Ginneken, Chris J., Van Cruchten, Steven J.

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Embryotoxicity in the mDarT: Is oxidative stress the key driver? by Pype, Casper, Verbueken, Evy, Saad, Moayad A., Casteleyn, Christophe, Van Ginneken, Chris J., Knapen, Dries, Van Cruchten, Steven J.

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Antioxidants reduce reactive oxygen species but not embryotoxicity in the metabolic Danio rerio test (mDarT) by Pype, Casper, Verbueken, Evy, Saad, Moayad A., Bars, Chloé, Van Ginneken, Chris J., Knapen, Dries, Van Cruchten, Steven J.

“…•Reactive oxygen species (ROS) are present in the metabolic Danio rerio test (mDarT).•Antioxidants reduce ROS in the coincubation medium of the mDarT but not…”
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Ontogeny of drug metabolism in the zebrafish: An in vitro study using human CYP-specific substrates by Saad, Moayad A., Verbueken, Evy, Pype, Casper, Casteleyn, Christophe R., Van Ginneken, Chris J., Maes, Louis, Cos, Paul, Van Cruchten, Steven J.

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Ontogeny of CYP1A in the zebrafish: An in vitro investigation by Saad, Moayad, Verbueken, Evy, Pype, Casper, Van Peer, Els, Casteleyn, Christophe, Van Ginneken, Chris, Van Cruchten, Steven

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Incubation at 32.5 degree C and above causes malformations in the zebrafish embryo by Pype, Casper, Verbueken, Evy, Saad, Moayad A, Casteleyn, Christophe R, Van Ginneken, Chris J, Knapen, Dries, Van Cruchten, Steven J

“…Zebrafish embryos are increasingly used for developmental toxicity screening of candidate drugs and are occasionally co-incubated with a metabolic activation…”
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Is CYP3A activity in the liver of adult zebrafish influenced by tricaine methanesulfonate (MS-222)? by Verbueken, Evy, Saad, Moayad, Pype, Casper, Van Peer, Els, Debille, Mariella, Casteleyn, Christophe, Van Ginneken, Chris, Van Cruchten, Steven

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