Search Results - "Pyott, Sonja J"

Age-Related Changes in the Cochlea and Vestibule: Shared Patterns and Processes by Paplou, Vasiliki, Schubert, Nick M. A., Pyott, Sonja J.

“…Both age-related hearing loss (ARHL) and age-related loss in vestibular function (ARVL) are prevalent conditions with deleterious consequences on the health…”
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The Stria Vascularis: Renewed Attention on a Key Player in Age-Related Hearing Loss by Bovee, Sonny, Klump, Georg M, Köppl, Christine, Pyott, Sonja J

“…Age-related hearing loss (HL), or presbycusis, is a complex and heterogeneous condition, affecting a significant portion of older adults and involving various…”
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The afferent signaling complex: Regulation of type I spiral ganglion neuron responses in the auditory periphery by Reijntjes, Daniël O.J., Pyott, Sonja J.

“…The spiral ganglion neurons (SGNs) are the first action potential generating neurons in the auditory pathway. The type I SGNs contact the sensory inner hair…”
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Glutamatergic signaling at the vestibular hair cell calyx synapse by Sadeghi, Soroush G, Pyott, Sonja J, Yu, Zhou, Glowatzki, Elisabeth

“…In the vestibular periphery a unique postsynaptic terminal, the calyx, completely covers the basolateral walls of type I hair cells and receives input from…”
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Cochlear Ribbon Synapses in Aged Gerbils by Bovee, Sonny, Klump, Georg M, Pyott, Sonja J, Sielaff, Charlotte, Köppl, Christine

“…In mammalian hearing, type-I afferent auditory nerve fibers comprise the basis of the afferent auditory pathway. They are connected to inner hair cells of the…”
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Functional, Morphological, and Evolutionary Characterization of Hearing in Subterranean, Eusocial African Mole-Rats by Pyott, Sonja J., van Tuinen, Marcel, Screven, Laurel A., Schrode, Katrina M., Bai, Jun-Ping, Barone, Catherine M., Price, Steven D., Lysakowski, Anna, Sanderford, Maxwell, Kumar, Sudhir, Santos-Sacchi, Joseph, Lauer, Amanda M., Park, Thomas J.

“…Naked mole-rats are highly vocal, eusocial, subterranean rodents with, counterintuitively, poor hearing. The causes underlying their altered hearing are…”
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A Combined Image- and Coordinate-Based Meta-Analysis of Whole-Brain Voxel-Based Morphometry Studies Investigating Subjective Tinnitus by Makani, Punitkumar, Thioux, Marc, Pyott, Sonja J., van Dijk, Pim

“…Previous voxel-based morphometry (VBM) studies investigating tinnitus have reported structural differences in a variety of spatially distinct gray matter…”
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Transcriptome-Guided Identification of Drugs for Repurposing to Treat Age-Related Hearing Loss by Schubert, Nick M A, van Tuinen, Marcel, Pyott, Sonja J

“…Age-related hearing loss (ARHL) or presbycusis is a prevalent condition associated with social isolation, cognitive impairment, and dementia. Age-related…”
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Hyperacusis is associated with smaller gray matter volumes in the supplementary motor area by Makani, Punitkumar, Koops, Elouise A., Pyott, Sonja J., van Dijk, Pim, Thioux, Marc

“…•Hyperacusis is characterized by hypersensitivity to ordinary environmental sounds.•Gray matter in the supplementary motor area is reduced in…”
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Circadian clock gene expression in the coral Favia fragum over diel and lunar reproductive cycles by Hoadley, Kenneth D, Szmant, Alina M, Pyott, Sonja J

“…Natural light cycles synchronize behavioral and physiological cycles over varying time periods in both plants and animals. Many scleractinian corals exhibit…”
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Hyperacusis in Tinnitus Individuals Is Associated with Smaller Gray Matter Volumes in the Supplementary Motor Area Regardless of Hearing Levels by Makani, Punitkumar, Thioux, Marc, Koops, Elouise A, Pyott, Sonja J, van Dijk, Pim

“…Recent evidence suggests a connection between hyperacusis and the motor system of the brain. For instance, our recent study reported that hyperacusis in…”
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Olivocochlear suppression of outer hair cells in vivo: evidence for combined action of BK and SK2 channels throughout the cochlea by Maison, Stéphane F, Pyott, Sonja J, Meredith, Andrea L, Liberman, M Charles

“…Cholinergic inhibition of cochlear hair cells via olivocochlear (OC)-efferent feedback is mediated by Ca(2+) entry through α9-/α10-nicotinic receptors, but the…”
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BK channels mediate cholinergic inhibition of high frequency cochlear hair cells by Wersinger, Eric, McLean, Will J, Fuchs, Paul A, Pyott, Sonja J

“…Outer hair cells are the specialized sensory cells that empower the mammalian hearing organ, the cochlea, with its remarkable sensitivity and frequency…”
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Changes in spontaneous movement in response to silent gaps are not robust enough to indicate the perception of tinnitus in mice by Reijntjes, Daniël O J, Schubert, Nick M A, Pietrus-Rajman, Alexander, van Dijk, Pim, Pyott, Sonja J

“…Approaches to identify the perception of tinnitus in various animal models have been difficult to apply to mouse. As a result, mice have been underutilized to…”
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Functional, Morphological and Molecular Changes Reveal the Mechanisms Associated with Age-Related Vestibular Loss by Paplou, Vasiliki Georgia, Schubert, Nick M. A, van Tuinen, Marcel, Vijayakumar, Sarath, Pyott, Sonja J

“…Age-related loss of vestibular function and hearing are common disorders that arise from the loss of function of the inner ear and significantly decrease…”
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The effects of temperature on vesicular supply and release in autaptic cultures of rat and mouse hippocampal neurons by Pyott, Sonja J., Rosenmund, Christian

“…Membrane fusion plays a central role in the synaptic vesicle cycle. While many of the pre- and postfusion events have been investigated at room temperature,…”
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Preparation of the intact rodent organ of Corti for RNAscope and immunolabeling, confocal microscopy, and quantitative analysis by Reijntjes, Daniel O.J., Breitzler, J. Lukas, Persic, Dora, Pyott, Sonja J.

“…This protocol describes the preparation of the mouse organ of Corti for RNAscope, immunolabeling, confocal microscopy, and quantitative image analysis to…”
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Harmony in the Molecular Orchestra of Hearing: Developmental Mechanisms from the Ear to the Brain by Pyott, Sonja J, Pavlinkova, Gabriela, Yamoah, Ebenezer N, Fritzsch, Bernd

“…Auditory processing in mammals begins in the peripheral inner ear and extends to the auditory cortex. Sound is transduced from mechanical stimuli into…”
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The crucial role of diverse animal models to investigate cochlear aging and hearing loss by Castaño-González, Karen, Köppl, Christine, Pyott, Sonja J.

“…•Age-related hearing loss due to cochlear pathology is a major health concern.•Identifying the underlying mechanisms requires comparison of diverse animal…”
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Slight and hidden hearing loss in young rats is associated with impaired recognition memory and reduced myelination in the corpus callosum by Jagersma, Joëlle D, Bakker, Marleen, Olivier, Jocelien D A, Pyott, Sonja J

“…Slight and hidden hearing loss in children have been linked to cognitive and social difficulties, and yet the neurobiological mechanisms behind these issues…”
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