Search Results - "Pye, R."

Bimetallic catalysis for C-C and C-X coupling reactions by Pye, Dominic R, Mankad, Neal P

“…Bimetallic catalysis represents an alternative paradigm for coupling chemistry that complements the more traditional single-site catalysis approach. In this…”
Get full text

Retrospective analysis of natural products provides insights for future discovery trends by Pye, Cameron R., Bertin, Matthew J., Lokey, R. Scott, Gerwick, William H., Linington, Roger G.

“…Understanding of the capacity of the natural world to produce secondary metabolites is important to a broad range of fields, including drug discovery, ecology,…”
Get full text

Drug‐Like Properties in Macrocycles above MW 1000: Backbone Rigidity versus Side‐Chain Lipophilicity by Furukawa, Akihiro, Schwochert, Joshua, Pye, Cameron R., Asano, Daigo, Edmondson, Quinn D., Turmon, Alexandra C., Klein, Victoria G., Ono, Satoshi, Okada, Okimasa, Lokey, R. Scott

“…Large macrocyclic peptides can achieve surprisingly high membrane permeability, although the properties that govern permeability in this chemical space are…”
Get full text

Lipophilic Permeability Efficiency Reconciles the Opposing Roles of Lipophilicity in Membrane Permeability and Aqueous Solubility by Naylor, Matthew R, Ly, Andrew M, Handford, Mason J, Ramos, Daniel P, Pye, Cameron R, Furukawa, Akihiro, Klein, Victoria G, Noland, Ryan P, Edmondson, Quinn, Turmon, Alexandra C, Hewitt, William M, Schwochert, Joshua, Townsend, Chad E, Kelly, Colin N, Blanco, Maria-Jesus, Lokey, R. Scott

“…As drug discovery moves increasingly toward previously “undruggable” targets such as protein–protein interactions, lead compounds are becoming larger and more…”
Get full text

Geometrically Diverse Lariat Peptide Scaffolds Reveal an Untapped Chemical Space of High Membrane Permeability by Kelly, Colin N, Townsend, Chad E, Jain, Ajay N, Naylor, Matthew R, Pye, Cameron R, Schwochert, Joshua, Lokey, R. Scott

“…Constrained, membrane-permeable peptides offer the possibility of engaging challenging intracellular targets. Structure-permeability relationships have been…”
Get full text

Astrocytes at the intersection of ageing, obesity, and neurodegeneration by Firth, Wyn, Pye, Katherine R, Weightman Potter, Paul G

“…Once considered passive cells of the central nervous system (CNS), glia are now known to actively maintain the CNS parenchyma; in recent years, the evidence…”
Get more information

Nonclassical Size Dependence of Permeation Defines Bounds for Passive Adsorption of Large Drug Molecules by Pye, Cameron R, Hewitt, William M, Schwochert, Joshua, Haddad, Terra D, Townsend, Chad E, Etienne, Lyns, Lao, Yongtong, Limberakis, Chris, Furukawa, Akihiro, Mathiowetz, Alan M, Price, David A, Liras, Spiros, Lokey, R. Scott

“…Macrocyclic peptides are considered large enough to inhibit “undruggable” targets, but the design of passively cell-permeable molecules in this space remains a…”
Get full text

Iron-Catalyzed Borylation of Alkyl, Allyl, and Aryl Halides: Isolation of an Iron(I) Boryl Complex by Bedford, Robin B, Brenner, Peter B, Carter, Emma, Gallagher, Timothy, Murphy, Damien M, Pye, Dominic R

“…Activation of B2pin2 with tBuLi facilitates the Fe-catalyzed borylation of alkyl, allyl, benzyl, and aryl halides via the formation of Li[B2pin2(tBu)] (1). The…”
Get full text

Passive Membrane Permeability in Cyclic Peptomer Scaffolds Is Robust to Extensive Variation in Side Chain Functionality and Backbone Geometry by Furukawa, Akihiro, Townsend, Chad E, Schwochert, Joshua, Pye, Cameron R, Bednarek, Maria A, Lokey, R. Scott

“…Synthetic and natural cyclic peptides provide a testing ground for studying membrane permeability in nontraditional drug scaffolds. Cyclic peptomers, which…”
Get full text

Identification of Late-Onset Hypogonadism in Middle-Aged and Elderly Men by Wu, Frederick C.W, Tajar, Abdelouahid, Beynon, Jennifer M, Pye, Stephen R, Silman, Alan J, Finn, Joseph D, O'Neill, Terence W, Bartfai, Gyorgy, Casanueva, Felipe F, Forti, Gianni, Giwercman, Aleksander, Han, Thang S, Kula, Krzysztof, Lean, Michael E.J, Pendleton, Neil, Punab, Margus, Boonen, Steven, Vanderschueren, Dirk, Labrie, Fernand, Huhtaniemi, Ilpo T

“…The investigators sought evidence-based criteria for identifying late-onset hypogonadism in men between the ages of 40 and 79 years on the basis of the…”
Get full text

Influenza and Pneumococcal Vaccination Uptake in Patients with Rheumatoid Arthritis Treated with Immunosuppressive Therapy in the UK: A Retrospective Cohort Study Using Data from the Clinical Practice Research Datalink by Costello, Ruth, Winthrop, Kevin L, Pye, Stephen R, Brown, Benjamin, Dixon, William G

“…Guidelines for the management of rheumatoid arthritis (RA) recommend using influenza and pneumococcal vaccinations to mitigate infection risk. The level of…”
Get full text

Hypothalamic-Pituitary-Testicular Axis Disruptions in Older Men Are Differentially Linked to Age and Modifiable Risk Factors: The European Male Aging Study by Wu, Frederick C. W., Tajar, Abdelouahid, Pye, Stephen R., Silman, Alan J., Finn, Joseph D., O'Neill, Terence W., Bartfai, Gyorgy, Casanueva, Felipe, Forti, Gianni, Giwercman, Aleksander, Huhtaniemi, Ilpo T., Kula, Krzysztof, Punab, Margus, Boonen, Steven, Vanderschueren, Dirk

“…Context: The cause of declining testosterone (T) in aging men and their relationships with risk factors are unclear. Objective: The objective of the study was…”
Get full text

Probing the Physicochemical Boundaries of Cell Permeability and Oral Bioavailability in Lipophilic Macrocycles Inspired by Natural Products by Bockus, Andrew T, Lexa, Katrina W, Pye, Cameron R, Kalgutkar, Amit S, Gardner, Jarret W, Hund, Kathryn C. R, Hewitt, William M, Schwochert, Joshua A, Glassey, Emerson, Price, David A, Mathiowetz, Alan M, Liras, Spiros, Jacobson, Matthew P, Lokey, R. Scott

“…Cyclic peptide natural products contain a variety of conserved, nonproteinogenic structural elements such as d-amino acids and amide N-methylation. In…”
Get full text

Characteristics of Androgen Deficiency in Late-Onset Hypogonadism: Results from the European Male Aging Study (EMAS) by Tajar, Abdelouahid, Huhtaniemi, Ilpo T, O'Neill, Terence W, Finn, Joseph D, Pye, Stephen R, Lee, David M, Bartfai, György, Boonen, Steven, Casanueva, Felipe F. F, Forti, Gianni, Giwercman, Aleksander, Han, Thang S, Kula, Krzysztof, Labrie, Fernand, Lean, Michael E. J, Pendleton, Neil, Punab, Margus, Vanderschueren, Dirk, Wu, Frederick C. W, the EMAS Group

“…Context: Late-onset hypogonadism (LOH) has been defined as a syndrome in middle-aged and elderly men reporting symptoms in the presence of low testosterone…”
Get full text

Age-associated changes in hypothalamic–pituitary–testicular function in middle-aged and older men are modified by weight change and lifestyle factors: longitudinal results from the European Male Ageing Study by Camacho, E M, Huhtaniemi, I T, O'Neill, T W, Finn, J D, Pye, S R, Lee, D M, Tajar, A, Bartfai, G, Boonen, S, Casanueva, F F, Forti, G, Giwercman, A, Han, T S, Kula, K, Keevil, B, Lean, M E, Pendleton, N, Punab, M, Vanderschueren, D, Wu, F C W

“…ObjectiveHealth and lifestyle factors are associated with variations in serum testosterone levels in ageing men. However, it remains unclear how age-related…”
Get full text

Retrieval of critically ill adults using extracorporeal membrane oxygenation: an Australian experience by Forrest, P., Ratchford, J., Burns, B., Herkes, R., Jackson, A., Plunkett, B., Torzillo, P., Nair, P., Granger, E., Wilson, M., Pye, R.

“…Purpose A retrieval program was developed in New South Wales (NSW), Australia to provide extracorporeal membrane oxygenation support (ECMO) for the safe…”
Get full text

Late-Onset Hypogonadism and Mortality in Aging Men by Pye, S. R, Huhtaniemi, I. T, Finn, J. D, Lee, D. M, O'Neill, T. W, Tajar, A, Bartfai, G, Boonen, S, Casanueva, F. F, Forti, G, Giwercman, A, Han, T. S, Kula, K, Lean, M. E, Pendleton, N, Punab, M, Rutter, M. K, Vanderschueren, D, Wu, F. C. W, the EMAS Study Group

“…Context: Late-onset hypogonadism (LOH) has recently been defined as a syndrome in middle-aged and elderly men reporting sexual symptoms in the presence of low…”
Get full text

Devil Facial Tumor Disease by Pye, R. J., Woods, G. M., Kreiss, A.

“…Devil facial tumor disease (DFTD) is an emergent transmissible cancer exclusive to Tasmanian devils (Sarcophilus harrisii) and threatening the species with…”
Get full text

Cytosolic 5'-nucleotidase 1A autoantibody profile and clinical characteristics in inclusion body myositis by Lilleker, J B, Rietveld, A, Pye, S R, Mariampillai, K, Benveniste, O, Peeters, M T J, Miller, J A L, Hanna, M G, Machado, P M, Parton, M J, Gheorghe, K R, Badrising, U A, Lundberg, I E, Sacconi, S, Herbert, M K, McHugh, N J, Lecky, B R F, Brierley, C, Hilton-Jones, D, Lamb, J A, Roberts, M E, Cooper, R G, Saris, C G J, Pruijn, G J M, Chinoy, H, van Engelen, B G M

“…Autoantibodies directed against cytosolic 5'-nucleotidase 1A have been identified in many patients with inclusion body myositis. This retrospective study…”
Get more information

CycLS: Accurate, whole-library sequencing of cyclic peptides using tandem mass spectrometry by Townsend, Chad, Furukawa, Akihiro, Schwochert, Joshua, Pye, Cameron R., Edmondson, Quinn, Lokey, R. Scott

“…[Display omitted] Cyclic peptides are of great interest as therapeutic compounds due to their potential for specificity and intracellular activity, but…”
Get full text