Search Results - "Pye, Quentin N"

Defining the catalytic activity of nanoceria in the P23H-1 rat, a photoreceptor degeneration model by Wong, Lily L, Pye, Quentin N, Chen, Lijuan, Seal, Sudipta, McGinnis, James F

“…Inorganic catalytic nanoceria or cerium oxide nanoparticles (CeNPs) are bona fide antioxidants that possess regenerative radical scavenging activities in…”
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Catalytic nanoceria are preferentially retained in the rat retina and are not cytotoxic after intravitreal injection by Wong, Lily L, Hirst, Suzanne M, Pye, Quentin N, Reilly, Christopher M, Seal, Sudipta, McGinnis, James F

“…Cerium oxide nanoparticles (nanoceria) possess catalytic and regenerative radical scavenging activities. The ability of nanoceria to maintain cellular redox…”
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Antioxidants in central nervous system diseases: preclinical promise and translational challenges by Kamat, Chandrashekhar D, Gadal, Sunyana, Mhatre, Molina, Williamson, Kelly S, Pye, Quentin N, Hensley, Kenneth

“…Oxidative damage is strongly implicated in the pathogenesis of neurodegenerative diseases including Alzheimer's disease, amyotrophic lateral sclerosis,…”
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On the relation of oxidative stress to neuroinflammation: lessons learned from the G93A-SOD1 mouse model of amyotrophic lateral sclerosis by Hensley, Kenneth, Mhatre, Molina, Mou, Shenyun, Pye, Quentin N, Stewart, Charles, West, Melinda, Williamson, Kelly S

“…The central nervous system (CNS) presents both challenges and opportunities to researchers of redox biochemistry. The CNS is sensitive to oxidative damage…”
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Message and protein-level elevation of tumor necrosis factor α (TNFα) and TNFα-modulating cytokines in spinal cords of the G93A-SOD1 mouse model for amyotrophic lateral sclerosis by Hensley, Kenneth, Fedynyshyn, Joe, Ferrell, Scott, Floyd, Robert A, Gordon, Brian, Grammas, Paula, Hamdheydari, Ladan, Mhatre, Molina, Mou, Shenyun, Pye, Quentin N, Stewart, Charles, West, Melinda, West, Stuart, Williamson, Kelly S

“…Recent data indicate that certain pro-inflammatory cytokines are transcriptionally upregulated in the spinal cords of G93A-SOD1 mice, a model of amyotrophic…”
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Temporal patterns of cytokine and apoptosis‐related gene expression in spinal cords of the G93A‐SOD1 mouse model of amyotrophic lateral sclerosis by Hensley, Kenneth, Floyd, Robert A., Gordon, Brian, Mou, Shenyun, Pye, Quentin N., Stewart, Charles, West, Melinda, Williamson, Kelly

“…Familial amyotrophic lateral sclerosis (FALS) is often caused by gain‐of‐function mutations in Cu,Zn‐superoxide dismutase (SOD1). Multiprobe ribonuclease…”
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Primary glia expressing the G93A-SOD1 mutation present a neuroinflammatory phenotype and provide a cellular system for studies of glial inflammation by Hensley, Kenneth, Abdel-Moaty, Haitham, Hunter, Jerrod, Mhatre, Molina, Mou, Shenyun, Nguyen, Kim, Potapova, Tamara, Pye, Quentin N, Qi, Min, Rice, Heather, Stewart, Charles, Stroukoff, Katharine, West, Melinda

“…Detailed study of glial inflammation has been hindered by lack of cell culture systems that spontaneously demonstrate the "neuroinflammatory phenotype". Mice…”
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A survey of sesamin and composition of tocopherol variability from seeds of eleven diverse sesame (Sesamum indicum L.) genotypes using HPLC-PAD-ECD by Williamson, Kelly S., Morris, J. Brad, Pye, Quentin N., Kamat, Chandrashekhar D., Hensley, Kenneth

“…The objective of this study was to determine the composition and content of sesamin and desmethyl tocopherols such as α‐tocopherol (αT), δ‐tocopherol (δT) and…”
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Correction: Catalytic Nanoceria Are Preferentially Retained in the Rat Retina and Are Not Cytotoxic after Intravitreal Injection by Wong, Lily L., Hirst, Suzanne M., Pye, Quentin N., Reilly, Christopher M., Seal, Sudipta, McGinnis, James F.

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Anti-inflammatory effects of tocopherol metabolites by Grammas, Paula, Hamdheydari, Ladan, Benaksas, Elaine J, Mou, Shenyun, Pye, Quentin N, Wechter, William J, Floyd, Robert A, Stewart, Charles, Hensley, Kenneth

“…Our objective was to assess the anti-inflammatory effects of α-tocopherol, γ-tocopherol, and their metabolites…”
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The arachidonic acid 5‐lipoxygenase inhibitor nordihydroguaiaretic acid inhibits tumor necrosis factor α activation of microglia and extends survival of G93A‐SOD1 transgenic mice by West, Melinda, Mhatre, Molina, Ceballos, Alex, Floyd, Robert A., Grammas, Paula, Gabbita, S. Prasad, Hamdheydari, Ladan, Mai, Tammy, Mou, Shenyun, Pye, Quentin N., Stewart, Charles, West, Stuart, Williamson, Kelly S., Zemlan, Frank, Hensley, Kenneth

“…Familial forms of amyotrophic lateral sclerosis (ALS) can be caused by mutations in copper, zinc‐superoxide dismutase (SOD1). Mice expressing SOD1 mutants…”
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Inhalation of environmental stressors & chronic inflammation: Autoimmunity and neurodegeneration by Gomez-Mejiba, Sandra E., Zhai, Zili, Akram, Hammad, Pye, Quentin N., Hensley, Kenneth, Kurien, Biji T., Scofield, R. Hal, Ramirez, Dario C.

“…Human life expectancy and welfare has decreased because of the increase in environmental stressors in the air. An environmental stressor is a natural or…”
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p38 Kinase Is Activated in the Alzheimer's Disease Brain by Hensley, Kenneth, Floyd, Robert A., Zheng, Nai‐Ying, Nael, Raha, Robinson, Kent A., Nguyen, Xuan, Pye, Quentin N., Stewart, Charles A., Geddes, James, Markesbery, William R., Patel, Ela, Johnson, Gail V. W., Bing, Guoying

“…: The p38 mitogen‐activated protein kinase is a stress‐activated enzyme responsible for transducing inflammatory signals and initiating apoptosis. In the…”
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Identification of Lanthionine Synthase C-like Protein-1 as a Prominent Glutathione Binding Protein Expressed in the Mammalian Central Nervous System by Chung, Charlotte H. Y, Kurien, Biji T, Mehta, Padmaja, Mhatre, Molina, Mou, Shenyun, Pye, Quentin N, Stewart, Charles, West, Melinda, Williamson, Kelly S, Post, Jan, Liu, Lucy, Wang, Rachel, Hensley, Kenneth

“…Proteomic experiments were performed to identify novel glutathione (GSH) binding proteins expressed in the mammalian central nervous system. Bovine brain…”
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The Nitration Product 5-Nitro-γ-tocopherol Is Increased in the Alzheimer Brain by Williamson, Kelly S., Prasad Gabbita, S., Mou, Shenyun, West, Melinda, Pye, Quentin N., Markesbery, William R., Cooney, Robert V., Grammas, Paula, Reimann-Philipp, Ulrich, Floyd, Robert A., Hensley, Kenneth

“…Oxidative stress and quasi-inflammatory processes recently have been recognized as contributing factors in the pathogenesis of Alzheimer's disease (AD)…”
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Mitochondrial dysfunction in choline deficiency-induced apoptosis in cultured rat hepatocytes by Guo, Wei-Xing, Pye, Quentin N, Williamson, Kelly S, Stewart, Charles A, Hensley, Kenneth L, Kotake, Yashige, Floyd, Robert A, Broyles, Robert H

“…Our recent studies have demonstrated that generation of ROS is associated with choline deficiency (CD)-induced apoptosis in CWSV-1 cells, an immortalized rat…”
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Redox-sensitive protein phosphatase activity regulates the phosphorylation state of p38 protein kinase in primary astrocyte culture by Robinson, Kent A., Stewart, Charles A., Pye, Quentin N., Nguyen, Xuan, Kenney, Lauren, Salzman, Scott, Floyd, Robert A., Hensley, Kenneth

“…Reactive oxygen species (ROS) have been implicated as second messengers that activate protein kinase cascades, although the means by which ROS regulate signal…”
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Reactive oxygen species in choline deficiency-induced apoptosis in rat hepatocytes by Guo, Wei-Xing, Pye, Quentin N., Williamson, Kelly S., Stewart, Charles A., Hensley, Kenneth L., Kotake, Yashige, Floyd, Robert A., Broyles, Robert H.

“…Choline deficiency (CD) is involved in hepatocellular carcinoma and CD-induced apoptosis may be implicated in cellular malignant transformation. In this…”
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Specific Repression of β-globin Promoter Activity by Nuclear Ferritin by Broyles, Robert H., Belegu, Visar, DeWitt, Christina R., Shah, Sandeep N., Stewart, Charles A., Pye, Quentin N., Floyd, Robert A.

“…Developmental hemoglobin switching involves sequential globin gene activations and repressions that are incompletely understood. Earlier observations,…”
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CPI-1189 inhibits interleukin 1 β-induced p38-mitogen-activated protein kinase phosphorylation: an explanation for its neuroprotective properties? by Hensley, Kenneth, Robinson, Kent A, Pye, Quentin N, Floyd, Robert.A, Cheng, Iona, Garland, William A, Irwin, Ian

“…The p38 mitogen-activated protein kinase (p38-MAPK) is a central enzyme in one of the major protein kinase cascades that regulate proapoptotic and…”
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