Determination of Solifenacin Succinate in Pure and Pharmaceutical Dosage forms by Spectrophotometry

Determination of Solifenacin Succinate in Pure and Pharmaceutical Dosage forms by Spectrophotometry

Four simple, precise and sensitive visible spectrophotometric methods were developed for the determination of solifenacin succinate in pure and pharmaceutical dosage forms. The proposed methods were based on the estimation of unreacted N-bromosuccinimide ( NBS ) with four dyes, namely, amaranth, saf...

Full description

Saved in:
Bibliographic Details
Published in:Journal of analytical chemistry (New York, N.Y.) Vol. 76; no. 11; pp. 1262 - 1270
Main Authors: Papanna, Roopa Kothathi, Kanakapura, Basavaiah, Gowda, Shankara Bujuvally Shivaiah, Basavaraju, Mahesh, Puttegowda, Veena Keregodu
Format: Journal Article
Language:English
Published: Moscow Pleiades Publishing 01-11-2021
Springer
Springer Nature B.V
Subjects:
Amaranth
Analysis
Analytical Chemistry
Aniline
Chemistry
Chemistry and Materials Science
Control equipment
Dexmedetomidine
Dosage
Laws, regulations and rules
Oxidation
Pantoprazole
Pharmaceuticals
Quality control
Reagents
Rhodamine
Solifenacin
Spectrophotometry
India
spectrophotometric determination
Vesicare
pharmaceuticals
drug quantification
NBS
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Four simple, precise and sensitive visible spectrophotometric methods were developed for the determination of solifenacin succinate in pure and pharmaceutical dosage forms. The proposed methods were based on the estimation of unreacted N-bromosuccinimide ( NBS ) with four dyes, namely, amaranth, safranin, aniline blue and rhodamine B, by the drug oxidation by known excess of NBS at laboratory temperature. Beer-Lambert’s law revealed good correlation in the concentration ranges of 10–70, 20–80, 30–80, and 10–50 µg/mL for methods A, B, C and D, respectively. The developed methods were successfully applied to the determination of solifenacin succinate in commercially available dosage forms. Statistical comparison of the results showed insignificant difference between the proposed methods and reference method. The proposed methods offered the advantages of simplicity and economy that can be applied without the need for expensive instrumentation and reagents in quality control analysis.
ISSN:1061-9348
1608-3199
DOI:10.1134/S1061934821110101