Search Results - "Putt, Karson S."

Regulation of CAR T cell-mediated cytokine release syndrome-like toxicity using low molecular weight adapters by Lee, Yong Gu, Chu, Haiyan, Lu, Yingjuan, Leamon, Christopher P., Srinivasarao, Madduri, Putt, Karson S., Low, Philip S.

“…Although chimeric antigen receptor (CAR) T cell therapies have demonstrated considerable success in treating hematologic malignancies, they have simultaneously…”
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Assessment of folate receptor alpha and beta expression in selection of lung and pancreatic cancer patients for receptor targeted therapies by Shen, Jiayin, Hu, Yingwen, Putt, Karson S, Singhal, Sunil, Han, Haiyong, Visscher, Daniel W, Murphy, Linda M, Low, Philip S

“…A number of folate receptor (FR) targeted small molecular drugs and monoclonal antibodies have been introduced into clinical trials to treat FR positive…”
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A novel micellular fluorogenic substrate for quantitating the activity of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma (PLCγ) enzymes by Visvanathan, Ramya, Utsuki, Tadanobu, Beck, Daniel E, Clayton, W Brent, Lendy, Emma, Sun, Kuai-Lin, Liu, Yinghui, Hering, Kirk W, Mesecar, Andrew, Zhang, Zhong-Yin, Putt, Karson S

“…The activities of the phospholipase C gamma (PLCγ) 1 and 2 enzymes are essential for numerous cellular processes. Unsurprisingly, dysregulation of PLCγ1 or…”
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Design of a Near Infrared Fluorescent Ureter Imaging Agent for Prevention of Ureter Damage during Abdominal Surgeries by Mahalingam, Sakkarapalayam M., Putt, Karson S., Srinivasarao, Madduri, Low, Philip S.

“…The inadvertent severing of a ureter during surgery occurs in as many as 4.5% of colorectal surgeries. To help prevent this issue, several near-infrared (NIR)…”
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Repolarization of Tumor-Infiltrating Myeloid Cells for Augmentation of CAR T Cell Therapies by Luo, Weichuan, Napoleon, John V, Zhang, Fenghua, Lee, Yong Gu, Wang, Bingbing, Putt, Karson S, Low, Philip S

“…Although CAR T cell therapies have proven to be effective in treating hematopoietic cancers, their abilities to regress solid tumors have been less…”
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A Small Molecule that Induces Intrinsic Pathway Apoptosis with Unparalleled Speed by Palchaudhuri, Rahul, Lambrecht, Michael J., Botham, Rachel C., Partlow, Kathryn C., van Ham, Tjakko J., Putt, Karson S., Nguyen, Laurie T., Kim, Seok-Ho, Peterson, Randall T., Fan, Timothy M., Hergenrother, Paul J.

“…Apoptosis is generally believed to be a process that requires several hours, in contrast to non-programmed forms of cell death that can occur in minutes. Our…”
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Depletion of activated macrophages with a folate receptor-beta-specific antibody improves symptoms in mouse models of rheumatoid arthritis by Hu, Yingwen, Wang, Bingbing, Shen, Jiayin, Low, Stewart A, Putt, Karson S, Niessen, Hans W M, Matteson, Eric L, Murphy, Linda, Ruppert, Clemens, Jansen, Gerrit, Oliver, Stephen J, Feng, Yang, Dimitrov, Dimiter S, Nickerson-Nutter, Cheryl, Low, Philip S

“…Most therapies for autoimmune and inflammatory diseases either neutralize or suppress production of inflammatory cytokines produced by activated macrophages…”
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Small-molecule activation of procaspase-3 to caspase-3 as a personalized anticancer strategy by Hergenrother, Paul J, Putt, Karson S, Hwang, Soon-Kyung, Cho, Myung-Haing, Kwon, Jung-Taek, Pearson, Jennifer M, Sandhorst, Joseph S, Helferich, William G, Chen, Grace W, Doerge, Daniel R, Hoagland, Martin S, Churchwell, Mona I, Jin, Hua

“…Mutation and aberrant expression of apoptotic proteins are hallmarks of cancer. These changes prevent proapoptotic signals from being transmitted to…”
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A high-throughput microtiter plate based method for the determination of peracetic acid and hydrogen peroxide by Putt, Karson S, Pugh, Randall B

“…Peracetic acid is gaining usage in numerous industries who have found a myriad of uses for its antimicrobial activity. However, rapid high throughput…”
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The Efficacy of Acanthamoeba Cyst Kill and Effects Upon Contact Lenses of a Novel Ultraviolet Lens Disinfection System by Lonnen, James, Putt, Karson S, Kernick, Edward R, Lakkis, Carol, May, Lauren, Pugh, Randall B

“…Purpose To assess the efficacy of a novel ultraviolet (UV) lens device on the killing of Acanthamoeba cysts and the impact of efficacious doses of UV upon soft…”
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A novel fluorogenic reporter substrate for 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 (PLCγ2): Application to high-throughput screening for activators to treat Alzheimer's disease by Visvanathan, Ramya, Utsuki, Tadanobu, Beck, Daniel E., Lendy, Emma, Sun, Kuai-lin, Liu, Yinghui, Hering, Kirk W., Mesecar, Andrew, Zhang, Zhong-Yin, Putt, Karson S.

“…A rare coding variant in PLCγ2 (P522R) expressed in microglia induces a mild activation of enzymatic activity when compared to wild-type. This mutation is…”
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An enzymatic assay for poly(ADP-ribose) polymerase-1 (PARP-1) via the chemical quantitation of NAD +: application to the high-throughput screening of small molecules as potential inhibitors by Putt, Karson S, Hergenrother, Paul J

“…The enzyme poly(adenosine 5 ′-diphosphate (ADP)-ribose) polymerase (PARP-1) catalyzes the formation of (ADP)-ribose polymers on a variety of protein acceptors…”
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Folate-Targeted Dendrimers Selectively Accumulate at Sites of Inflammation in Mouse Models of Ulcerative Colitis and Atherosclerosis by Poh, Scott, Putt, Karson S, Low, Philip S

“…Folate-receptor-positive activated macrophages are critical for the development and maintenance of many chronic inflammatory and autoimmune diseases…”
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The use of chromophore and fluorophore degradation to quantitate UV dose: FD&C dyes as chemical identicators for UV sterilization by Putt, Karson S., Kernick, Edward R., Lohse, Brieanna K., Lomboy, James, O'Brien, Terry, Pugh, Randall B.

“…The accurate measurement of ultraviolet (UV) irradiation, especially within a container or vessel is one of the challenges facing the broad implementation of…”
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Selective liposome targeting of folate receptor positive immune cells in inflammatory diseases by Poh, Scott, Chelvam, Venkatesh, Ayala-López, Wilfredo, Putt, Karson S., Low, Philip S.

“…Activated macrophages play a key role in the development and maintenance of inflammatory diseases such as atherosclerosis, lupus, psoriasis, rheumatoid…”
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Discovery and evaluation of novel SHIP-1 inhibitors by Miao, Jinmin, Lin, Jianping, Dong, Jiajun, Amarasinghe, Ovini, Mason, Emily R., Chu, Shaoyou, Qu, Zihan, Cullers, Clayton C., Putt, Karson S., Zhang, Zhong-Yin

“…[Display omitted] •A high-throughput screening platform was implemented to explore SHIP-1 modulators.•Three novel SHIP-1 inhibitor scaffolds with low µM IC50s…”
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DARC, Glycophorin A, Band 3, and GLUT1 Diffusion in Erythrocytes: Insights into Membrane Complexes by Kodippili, Gayani C., Giger, Katie, Putt, Karson S., Low, Philip S.

“…Single-particle tracking offers a method to interrogate the organization of transmembrane proteins by measuring their mobilities within a cell’s plasma…”
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Imatinib augments standard malaria combination therapy without added toxicity by Chien, Huynh Dinh, Pantaleo, Antonella, Kesely, Kristina R, Noomuna, Panae, Putt, Karson S, Tuan, Tran Anh, Low, Philip S, Turrini, Francesco M

“…To egress from its erythrocyte host, the malaria parasite, Plasmodium falciparum, must destabilize the erythrocyte membrane by activating an erythrocyte…”
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A Colorimetric Substrate for Poly(ADP-Ribose) Polymerase-1, VPARP, and Tankyrase-1 by Nottbohm, Amanda C., Dothager, Robin S., Putt, Karson S., Hoyt, Mirth T., Hergenrother, Paul J.

“…Color me yellow: Poly(ADP‐ribose) polymerases (PARPs) play a major role in cellular survival and maintenance of energy stores after genotoxic insult. The…”
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Evaluation of a Carbonic Anhydrase IX-Targeted Near-Infrared Dye for Fluorescence-Guided Surgery of Hypoxic Tumors by Lv, Peng-Cheng, Roy, Jyoti, Putt, Karson S, Low, Philip S

“…Proof-of-principle studies in ovarian, lung, and brain cancer patients have shown that fluorescence-guided surgery can enable removal of otherwise undetectable…”
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