Green Dentistry in Oral Cancer Treatment Using Biosynthesis Superparamagnetic Iron Oxide Nanoparticles: A Systematic Review

Green Dentistry in Oral Cancer Treatment Using Biosynthesis Superparamagnetic Iron Oxide Nanoparticles: A Systematic Review

Oral cancer is a worldwide health issue with high incidence and mortality, demands an effective treatment to improve patient prognosis. Superparamagnetic iron oxide nanoparticles (SPIONs) emerged as a candidate for oral cancer treatment due to their unique attributes, enabling a synergistic combinat...

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Bibliographic Details
Published in:Cancer management and research Vol. 16; pp. 1231 - 1245
Main Authors: Reviansyah, Faris Hernando, Putra, Daffa Rahmad Dwiyana, Supriatna, Juan Alexander, Takarini, Veni, Komariah, Maria
Format: Journal Article
Language:English
Published: New Zealand Dove Medical Press Limited 01-01-2024
Dove
Dove Medical Press
Subjects:
Antioxidants
Biopolymers
Biosynthesis
Cancer
Care and treatment
Drug delivery systems
Drug therapy
Drugs
Ferric oxide
green dentistry
Health aspects
Iron compounds
Lignin
Mouth cancer
Nanoparticles
Oncology, Experimental
oral cancer
Prognosis
Review
spions
treatment
Vehicles
Indonesia
green dentistry
treatment
SPIONs
oral cancer
biosynthesis
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Summary:Oral cancer is a worldwide health issue with high incidence and mortality, demands an effective treatment to improve patient prognosis. Superparamagnetic iron oxide nanoparticles (SPIONs) emerged as a candidate for oral cancer treatment due to their unique attributes, enabling a synergistic combination with its drug-delivery capabilities and hyperthermia when exposed to magnetic fields. SPIONs can be synthesized using biopolymers from agricultural waste like lignin from paddy, which produce biogenic nano iron oxide with superparamagnetic and antioxidant effects. In addition, lignin also acts as a stabilizing agent in creating SPIONs. This study aimed to explore how agricultural waste could be used to prepare SPIONs using the green synthesis method and to evaluate its potential for oral cancer specifically focusing on its effectiveness, side effects, biocompatibility, and toxicity. A systematic review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses protocol. PubMed, EBSCO, and Scopus databases were exploited in the selection of articles published within the last decade. This study quality assessment uses OHAT for critical appraisal tools. Only 10 studies met the inclusion criteria. The findings suggest that the use of agricultural waste in the preparation of SPIONs not only holds potency for oral cancer treatment through drug delivery and hyperthermia but also aligns with the concept of green dentistry. SPIONs as a treatment modality for oral cancer have demonstrated notable effectiveness and versatility. This study provides robust evidence supporting green dentistry by using agricultural waste in the preparation and formulation of SPIONs for managing oral cancer. Its multifunctional nature and ability to enhance treatment efficacy while minimizing adverse effects on healthy tissues highlights the potency of SPION-based oral cancer treatments.
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These authors contributed equally to this work
ISSN:1179-1322
1179-1322
DOI:10.2147/CMAR.S477791