Search Results - "Putluri, NagiReddy"

Dimethyl fumarate targets GAPDH and aerobic glycolysis to modulate immunity by Kornberg, Michael D, Bhargava, Pavan, Kim, Paul M, Putluri, Vasanta, Snowman, Adele M, Putluri, Nagireddy, Calabresi, Peter A, Snyder, Solomon H

“…Activated immune cells undergo a metabolic switch to aerobic glycolysis akin to the Warburg effect, thereby presenting a potential therapeutic target in…”
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The Glia-Neuron Lactate Shuttle and Elevated ROS Promote Lipid Synthesis in Neurons and Lipid Droplet Accumulation in Glia via APOE/D by Liu, Lucy, MacKenzie, Kevin R., Putluri, Nagireddy, Maletić-Savatić, Mirjana, Bellen, Hugo J.

“…Elevated reactive oxygen species (ROS) induce the formation of lipids in neurons that are transferred to glia, where they form lipid droplets (LDs). We show…”
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Circadian Homeostasis of Liver Metabolism Suppresses Hepatocarcinogenesis by Kettner, Nicole M., Voicu, Horatio, Finegold, Milton J., Coarfa, Cristian, Sreekumar, Arun, Putluri, Nagireddy, Katchy, Chinenye A., Lee, Choogon, Moore, David D., Fu, Loning

“…Chronic jet lag induces spontaneous hepatocellular carcinoma (HCC) in wild-type mice following a mechanism very similar to that observed in obese humans. The…”
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Gut Microbiota–Derived Short-Chain Fatty Acids Promote Poststroke Recovery in Aged Mice by Lee, Juneyoung, d’Aigle, John, Atadja, Louise, Quaicoe, Victoria, Honarpisheh, Pedram, Ganesh, Bhanu P., Hassan, Ahmad, Graf, Joerg, Petrosino, Joseph, Putluri, Nagireddy, Zhu, Liang, Durgan, David J., Bryan, Robert M., McCullough, Louise D., Venna, Venugopal Reddy

“…RATIONALE:The elderly experience profound systemic responses after stroke, which contribute to higher mortality and more severe long-term disability. Recent…”
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Age‐related changes in the gut microbiota influence systemic inflammation and stroke outcome by Spychala, Monica S., Venna, Venugopal Reddy, Jandzinski, Michal, Doran, Sarah J., Durgan, David J., Ganesh, Bhanu Priya, Ajami, Nadim J., Putluri, Nagireddy, Graf, Joerg, Bryan, Robert M., McCullough, Louise D.

“…Objective Chronic systemic inflammation contributes to the pathogenesis of many age‐related diseases. Although not well understood, alterations in the gut…”
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Electronic cigarettes disrupt lung lipid homeostasis and innate immunity independent of nicotine by Madison, Matthew C, Landers, Cameron T, Gu, Bon-Hee, Chang, Cheng-Yen, Tung, Hui-Ying, You, Ran, Hong, Monica J, Baghaei, Nima, Song, Li-Zhen, Porter, Paul, Putluri, Nagireddy, Salas, Ramiro, Gilbert, Brian E, Levental, Ilya, Campen, Matthew J, Corry, David B, Kheradmand, Farrah

“…Electronic nicotine delivery systems (ENDS) or e-cigarettes have emerged as a popular recreational tool among adolescents and adults. Although the use of ENDS…”
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XBP1 links the 12-hour clock to NAFLD and regulation of membrane fluidity and lipid homeostasis by Meng, Huan, Gonzales, Naomi M., Lonard, David M., Putluri, Nagireddy, Zhu, Bokai, Dacso, Clifford C., York, Brian, O’Malley, Bert W.

“…A distinct 12-hour clock exists in addition to the 24-hour circadian clock to coordinate metabolic and stress rhythms. Here, we show that liver-specific…”
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Metabolic enzyme PFKFB4 activates transcriptional coactivator SRC-3 to drive breast cancer by Dasgupta, Subhamoy, Rajapakshe, Kimal, Zhu, Bokai, Nikolai, Bryan C., Yi, Ping, Putluri, Nagireddy, Choi, Jong Min, Jung, Sung Y., Coarfa, Cristian, Westbrook, Thomas F., Zhang, Xiang H.-F., Foulds, Charles E., Tsai, Sophia Y., Tsai, Ming-Jer, O’Malley, Bert W.

“…Alterations in both cell metabolism and transcriptional programs are hallmarks of cancer that sustain rapid proliferation and metastasis 1 . However, the…”
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KMT2D Deficiency Impairs Super-Enhancers to Confer a Glycolytic Vulnerability in Lung Cancer by Alam, Hunain, Tang, Ming, Maitituoheti, Mayinuer, Dhar, Shilpa S., Kumar, Manish, Han, Chae Young, Ambati, Chandrashekar R., Amin, Samir B., Gu, Bingnan, Chen, Tsai-Yu, Lin, Yu-Hsi, Chen, Jichao, Muller, Florian L., Putluri, Nagireddy, Flores, Elsa R., DeMayo, Francesco J., Baseler, Laura, Rai, Kunal, Lee, Min Gyu

“…Epigenetic modifiers frequently harbor loss-of-function mutations in lung cancer, but their tumor-suppressive roles are poorly characterized. Histone…”
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Aerobic Plus Resistance Exercise in Obese Older Adults Improves Muscle Protein Synthesis and Preserves Myocellular Quality Despite Weight Loss by Colleluori, Georgia, Aguirre, Lina, Phadnis, Uma, Fowler, Kenneth, Armamento-Villareal, Reina, Sun, Zheng, Brunetti, Lorenzo, Hyoung Park, Jun, Kaipparettu, Benny Abraham, Putluri, Nagireddy, Auetumrongsawat, Vimlin, Yarasheski, Kevin, Qualls, Clifford, Villareal, Dennis T.

“…Anabolic resistance and impaired myocellular quality contribute to age-related sarcopenia, which exacerbates with obesity. Diet-induced muscle mass loss is…”
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Epigenome environment interactions accelerate epigenomic aging and unlock metabolically restricted epigenetic reprogramming in adulthood by Treviño, Lindsey S., Dong, Jianrong, Kaushal, Ahkilesh, Katz, Tiffany A., Jangid, Rahul Kumar, Robertson, Matthew J., Grimm, Sandra L., Ambati, Chandra Shekar R., Putluri, Vasanta, Cox, Aaron R., Kim, Kang Ho, May, Thaddeus D., Gallo, Morgan R., Moore, David D., Hartig, Sean M., Foulds, Charles E., Putluri, Nagireddy, Coarfa, Cristian, Walker, Cheryl Lyn

“…Our early-life environment has a profound influence on developing organs that impacts metabolic function and determines disease susceptibility across the…”
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Polycyclic Aromatic Hydrocarbon-induced Pulmonary Carcinogenesis in Cytochrome P450 (CYP)1A1- and 1A2-Null Mice: Roles of CYP1A1 and CYP1A2 by Gastelum, Grady, Jiang, Weiwu, Wang, Lihua, Zhou, Guodong, Borkar, Roshan, Putluri, Nagireddy, Moorthy, Bhagavatula

“…Abstract In 2019, lung cancer was estimated to be the leading cause of cancer deaths in humans. Polycyclic aromatic hydrocarbons (PAHs) are known to increase…”
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Restoration of the molecular clock is tumor suppressive in neuroblastoma by Moreno-Smith, Myrthala, Milazzo, Giorgio, Tao, Ling, Fekry, Baharan, Zhu, Bokai, Mohammad, Mahmoud A., Di Giacomo, Simone, Borkar, Roshan, Reddy, Karthik Reddy Kami, Capasso, Mario, Vasudevan, Sanjeev A., Sumazin, Pavel, Hicks, John, Putluri, Nagireddy, Perini, Giovanni, Eckel-Mahan, Kristin, Burris, Thomas P., Barbieri, Eveline

“…MYCN activation is a hallmark of advanced neuroblastoma (NB) and a known master regulator of metabolic reprogramming, favoring NB adaptation to its…”
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Young versus aged microbiota transplants to germ-free mice: increased short-chain fatty acids and improved cognitive performance by Lee, Juneyoung, Venna, Venugopal R., Durgan, David J., Shi, Huanan, Hudobenko, Jacob, Putluri, Nagireddy, Petrosino, Joseph, McCullough, Louise D., Bryan, Robert M.

“…Aging is associated with cognitive decline and decreased concentrations of short-chain fatty acids (SCFAs) in the gut. SCFAs are significant in that they are…”
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Cisplatin generates oxidative stress which is accompanied by rapid shifts in central carbon metabolism by Yu, Wangie, Chen, Yunyun, Dubrulle, Julien, Stossi, Fabio, Putluri, Vasanta, Sreekumar, Arun, Putluri, Nagireddy, Baluya, Dodge, Lai, Stephen Y., Sandulache, Vlad C.

“…Cisplatin is commonly utilized in the treatment of solid tumors. Its mechanism of action is complex and multiple mechanisms of resistance have been described…”
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Oncogenic KRAS-Driven Metabolic Reprogramming in Pancreatic Cancer Cells Utilizes Cytokines from the Tumor Microenvironment by Dey, Prasenjit, Li, Jun, Zhang, Jianhua, Chaurasiya, Surendra, Strom, Anders, Wang, Huamin, Liao, Wen-Ting, Cavallaro, Frederick, Denz, Parker, Bernard, Vincent, Yen, Er-Yen, Genovese, Giannicola, Gulhati, Pat, Liu, Jielin, Chakravarti, Deepavali, Deng, Pingna, Zhang, Tingxin, Carbone, Federica, Chang, Qing, Ying, Haoqiang, Shang, Xiaoying, Spring, Denise J, Ghosh, Bidyut, Putluri, Nagireddy, Maitra, Anirban, Wang, Y Alan, DePinho, Ronald A

“…A hallmark of pancreatic ductal adenocarcinoma (PDAC) is an exuberant stroma comprised of diverse cell types that enable or suppress tumor progression. Here,…”
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Pentose Phosphate Shunt Modulates Reactive Oxygen Species and Nitric Oxide Production Controlling Trypanosoma cruzi in Macrophages by Koo, Sue-Jie, Szczesny, Bartosz, Wan, Xianxiu, Putluri, Nagireddy, Garg, Nisha Jain

“…Metabolism provides substrates for reactive oxygen species (ROS) and nitric oxide (NO) generation, which are a part of the macrophage (Mφ) anti-microbial…”
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Pharmacological targeting of MYC-regulated IRE1/XBP1 pathway suppresses MYC-driven breast cancer by Zhao, Na, Cao, Jin, Xu, Longyong, Tang, Qianzi, Dobrolecki, Lacey E, Lv, Xiangdong, Talukdar, Manisha, Lu, Yang, Wang, Xiaoran, Hu, Dorothy Z, Shi, Qing, Xiang, Yu, Wang, Yunfei, Liu, Xia, Bu, Wen, Jiang, Yi, Li, Mingzhou, Gong, Yingyun, Sun, Zheng, Ying, Haoqiang, Yuan, Bo, Lin, Xia, Feng, Xin-Hua, Hartig, Sean M, Li, Feng, Shen, Haifa, Chen, Yiwen, Han, Leng, Zeng, Qingping, Patterson, John B, Kaipparettu, Benny Abraham, Putluri, Nagireddy, Sicheri, Frank, Rosen, Jeffrey M, Lewis, Michael T, Chen, Xi

“…The unfolded protein response (UPR) is a cellular homeostatic mechanism that is activated in many human cancers and plays pivotal roles in tumor progression…”
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PTEN-induced partial epithelial-mesenchymal transition drives diabetic kidney disease by Li, Yajuan, Hu, Qingsong, Li, Chunlai, Liang, Ke, Xiang, Yu, Hsiao, Heidi, Nguyen, Tina K, Park, Peter K, Egranov, Sergey D, Ambati, Chandrashekar R, Putluri, Nagireddy, Hawke, David H, Han, Leng, Hung, Mien-Chie, Danesh, Farhad R, Yang, Liuqing, Lin, Chunru

“…Epithelial-mesenchymal transition (EMT) contributes significantly to interstitial matrix deposition in diabetic kidney disease (DKD). However, detection of EMT…”
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Histone H2A Lys130 acetylation epigenetically regulates androgen production in prostate cancer by Nguyen, Thanh, Sridaran, Dhivya, Chouhan, Surbhi, Weimholt, Cody, Wilson, Audrey, Luo, Jingqin, Li, Tiandao, Koomen, John, Fang, Bin, Putluri, Nagireddy, Sreekumar, Arun, Feng, Felix Y., Mahajan, Kiran, Mahajan, Nupam P.

“…The testicular androgen biosynthesis is well understood, however, how cancer cells gauge dwindling androgen to dexterously initiate its de novo synthesis…”
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