Search Results - "Putavet, Diana A."

Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging by Baar, Marjolein P., Brandt, Renata M.C., Putavet, Diana A., Klein, Julian D.D., Derks, Kasper W.J., Bourgeois, Benjamin R.M., Stryeck, Sarah, Rijksen, Yvonne, van Willigenburg, Hester, Feijtel, Danny A., van der Pluijm, Ingrid, Essers, Jeroen, van Cappellen, Wiggert A., van IJcken, Wilfred F., Houtsmuller, Adriaan B., Pothof, Joris, de Bruin, Ron W.F., Madl, Tobias, Hoeijmakers, Jan H.J., Campisi, Judith, de Keizer, Peter L.J.

“…The accumulation of irreparable cellular damage restricts healthspan after acute stress or natural aging. Senescent cells are thought to impair tissue…”
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Residual Disease in Glioma Recurrence: A Dangerous Liaison with Senescence by Putavet, Diana A, de Keizer, Peter L J

“…With a dismally low median survival of less than two years after diagnosis, Glioblastoma (GBM) is the most lethal type of brain cancer. The standard-of-care of…”
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Re-purposing the pro-senescence properties of doxorubicin to introduce immunotherapy in breast cancer brain metastasis by Uceda-Castro, Rebeca, Margarido, Andreia S., Cornet, Lesley, Vegna, Serena, Hahn, Kerstin, Song, Ji-Ying, Putavet, Diana A., van Geldorp, Mariska, Çitirikkaya, Ceren H., de Keizer, Peter L.J., ter Beek, Leon C., Borst, Gerben R., Akkari, Leila, van Tellingen, Olaf, Broekman, Marike L.D., Vennin, Claire, van Rheenen, Jacco

“…An increasing number of breast cancer patients develop brain metastases (BM). Standard-of-care treatments are largely inefficient, and breast cancer brain…”
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Abstract 2843: TASC1, a selective anti-senescence therapeutic which potently and selectively counteract resistance to chemo- and radiotherapy by Baar, Marjolein P., Putavet, Diana A., Pothof, Joris, Hoeijmakers, Jan H.J., de Keizer, Peter L.J.

“…Abstract Resistance to therapy is a major limitation towards the cure of irresectable cancer. Cellular senescence, induced by chemotherapy and radiotherapy,…”
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Abstract IA002: Targeting senescence heterogeneity against cancer therapy-resistance and metastases by Putavet, Diana A., Lehmann, Johannes, Subtil, Beatriz, Hofman, Damon, Baar, Marjolein P., de Keizer, Peter L.J.

“…Abstract Therapy resistance of metastatic tumor cells poses a major limitation to the cure of cancer. Aside from cell-intrinsic processes, the tumor…”
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