Inhibitory Activity and Docking Analysis of Antimalarial Agents from Stemona sp. toward Ferredoxin-NADP+ Reductase from Malaria Parasites

Inhibitory Activity and Docking Analysis of Antimalarial Agents from Stemona sp. toward Ferredoxin-NADP+ Reductase from Malaria Parasites

Ferredoxin-NADP+ reductases (FNRs, EC 1.18.1.2) were found in the plastids of Plasmodium and have been considered as a target for the development of new antimalarial agents. Croomine, epi-croomine, tuberostemonine, javastemonine A, and isoprotostemonine are isolated alkaloids from the roots of Stemo...

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Bibliographic Details
Published in:Journal of parasitology research Vol. 2018; no. 2018; pp. 1 - 6
Main Authors: Nahar, Lutfun, Hase, Toshiharu, Ariga, Yoko K., Fanani, Much. Z., Siswanto, Imam, Puspaningsih, Ni Nyoman T., Pudjiastuti, Pratiwi, Sarker, Satyajit D.
Format: Journal Article
Language:English
Published: Cairo, Egypt Hindawi Publishing Corporation 2018
Hindawi
John Wiley & Sons, Inc
Hindawi Limited
Subjects:
Alkaloids
Antimalarials
Electron transport
Malaria
Plasmodium falciparum
Pyrimethamine
Online Access:Get full text
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Summary:Ferredoxin-NADP+ reductases (FNRs, EC 1.18.1.2) were found in the plastids of Plasmodium and have been considered as a target for the development of new antimalarial agents. Croomine, epi-croomine, tuberostemonine, javastemonine A, and isoprotostemonine are isolated alkaloids from the roots of Stemona sp. and their inhibitory effect on FNRs from Plasmodium falciparum (PfFNR) was investigated. Croomine showed the highest level of inhibition (33.9%) of electron transfer from PfFNR to PfFd, while tuberstemonine displayed the highest level of inhibition (55.4%) of diaphorase activity of PfFNR. Docking analysis represented that croomine is located at the middle position of PfFNR and PfFd. Croomine from S. tuberosa appeared to have potential as an antimalarial agent.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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Academic Editor: José F. Silveira
ISSN:2090-0023
2090-0031
DOI:10.1155/2018/3469132