Search Results - "Pushko, Peter"

Influenza Virus Like Particles (VLPs): Opportunities for H7N9 Vaccine Development by Pushko, Peter, Tretyakova, Irina

“…In the midst of the ongoing COVID-19 coronavirus pandemic, influenza virus remains a major threat to public health due to its potential to cause epidemics and…”
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Development of virus-like particle technology from small highly symmetric to large complex virus-like particle structures by Pushko, Peter, Pumpens, Paul, Grens, Elmars

“…Virus-like particle (VLP) technology is a promising approach for the construction of novel vaccines, diagnostic tools, and gene therapy vectors. Initially,…”
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Replication of the Venezuelan Equine Encephalitis Vaccine from a Synthetic PCR Fragment by Mathew, Christine, Tucker, Colin, Tretyakova, Irina, Pushko, Peter

“…There is no approved human vaccine for Venezuelan equine encephalitis (VEE), a life-threatening disease caused by the VEE virus (VEEV). In previous studies,…”
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Single-Dose Immunogenic DNA Vaccines Coding for Live-Attenuated Alpha- and Flaviviruses by Pushko, Peter, Lukashevich, Igor S, Johnson, Dylan M, Tretyakova, Irina

“…Single-dose, immunogenic DNA (iDNA) vaccines coding for whole live-attenuated viruses are reviewed. This platform, sometimes called immunization DNA, has been…”
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A Novel Application of Virus Like Particles in the Hemagglutination Inhibition Assay by El-Husseiny, Mohamed H, Pushko, Peter, Tretyakova, Irina, Hagag, Naglaa M, Abdel-Mawgod, Sara, Shabaan, Ahmed, Bakry, Neveen R, Arafa, Abdel Satar

“…The hemagglutination inhibition (HI) assay is a traditional laboratory procedure for detection and quantitation of serum antibodies of hemagglutinating viruses…”
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Universal protection against influenza viruses by multi-subtype neuraminidase and M2 ectodomain virus-like particle by Kim, Ki-Hye, Li, Zhuo, Bhatnagar, Noopur, Subbiah, Jeeva, Park, Bo Ryoung, Shin, Chong Hyun, Pushko, Peter, Wang, Bao-Zhong, Kang, Sang-Moo

“…Annual influenza vaccination is recommended to update the variable hemagglutinin antigens. Here, we first designed a virus-like particle (VLP) displaying…”
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Live-attenuated CHIKV vaccine with rearranged genome replicates in vitro and induces immune response in mice by Tretyakova, Irina, Joh, Joongho, Gearon, Mary, Kraenzle, Jennifer, Goedeker, Sidney, Pignataro, Ava, Alejandro, Brian, Lukashevich, Igor S, Chung, Donghoon, Pushko, Peter

“…Chikungunya fever virus (CHIKV) is a mosquito-borne alphavirus that causes wide-spread human infections and epidemics in Asia, Africa and recently, in the…”
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Neuraminidase-based recombinant virus-like particles protect against lethal avian influenza A(H5N1) virus infection in ferrets by Smith, Gale E, Sun, Xiangjie, Bai, Yaohui, Liu, Ye V, Massare, Michael J, Pearce, Melissa B, Belser, Jessica A, Maines, Taronna R, Creager, Hannah M, Glenn, Gregory M, Flyer, David, Pushko, Peter, Levine, Min Z, Tumpey, Terrence M

“…Abstract Avian influenza A (H5N1) viruses represent a growing threat for an influenza pandemic. The presence of widespread avian influenza virus infections…”
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Intranasal Vaccination with 1918 Influenza Virus-Like Particles Protects Mice and Ferrets from Lethal 1918 and H5N1 Influenza Virus Challenge by PERRONE, Lucy A, AHMAD, Attiya, VEGUILLA, Vic, XIUHUA LU, SMITH, Gale, KATZ, Jacqueline M, PUSHKO, Peter, TUMPEY, Terrence M

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Cross-clade protective immune responses to influenza viruses with H5N1 HA and NA elicited by an influenza virus-like particle by Bright, Rick A, Carter, Donald M, Crevar, Corey J, Toapanta, Franklin R, Steckbeck, Jonathan D, Cole, Kelly S, Kumar, Niranjan M, Pushko, Peter, Smith, Gale, Tumpey, Terrence M, Ross, Ted M

“…Vaccination is a cost-effective counter-measure to the threat of seasonal or pandemic outbreaks of influenza. To address the need for improved influenza…”
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Evaluation of Protective Efficacy of Influenza Virus Like Particles Prepared from H5N1 Virus of Clade 2.2.1.2 in Chickens by El-Husseiny, Mohamed H., Hagag, Naglaa M., Pushko, Peter, Tretyakova, Irina, Naguib, Mahmoud M., Arafa, Abdel Satar

“…Highly pathogenic Avian Influenza (HPAI) viruses continue to cause severe economic losses in poultry species worldwide. HPAI virus of subtype H5N1 was reported…”
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Evaluation in nonhuman primates of vaccines against Ebola virus by Geisbert, Thomas W, Pushko, Peter, Anderson, Kevin, Smith, Jonathan, Davis, Kelly J, Jahrling, Peter B

“…Ebola virus (EBOV) causes acute hemorrhagic fever that is fatal in up to 90% of cases in both humans and nonhuman primates. No vaccines or treatments are…”
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Advanced Safety and Genetic Stability in Mice of a Novel DNA-Launched Venezuelan Equine Encephalitis Virus Vaccine with Rearranged Structural Genes by Johnson, Dylan M, Sokoloski, Kevin J, Jokinen, Jenny D, Pfeffer, Tia L, Chu, Yong-Kyu, Adcock, Robert S, Chung, Donghoon, Tretyakova, Irina, Pushko, Peter, Lukashevich, Igor S

“…The safety and genetic stability of V4020, a novel Venezuelan Equine Encephalitis Virus (VEEV) vaccine based on the investigational VEEV TC-83 strain, was…”
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Incorporation of High Levels of Chimeric Human Immunodeficiency Virus Envelope Glycoproteins into Virus-Like Particles by Wang, Bao-Zhong, Liu, Weimin, Kang, Sang-Moo, Alam, Munir, Huang, Chunzi, Ye, Ling, Sun, Yuliang, Li, Yingying, Kothe, Denise L, Pushko, Peter, Dokland, Terje, Haynes, Barton F, Smith, Gale, Hahn, Beatrice H, Compans, Richard W

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Individual and Bivalent Vaccines Based on Alphavirus Replicons Protect Guinea Pigs against Infection with Lassa and Ebola Viruses by Pushko, P, Geisbert, J, Parker, M, Jahrling, P, Smith, J

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Recombinant RNA replicons derived from attenuated Venezuelan equine encephalitis virus protect guinea pigs and mice from Ebola hemorrhagic fever virus by Pushko, Peter, Bray, Mike, Ludwig, George V, Parker, Michael, Schmaljohn, Alan, Sanchez, Anthony, Jahrling, Peter B, Smith, Jonathan F

“…RNA replicons derived from an attenuated strain of Venezuelan equine encephalitis virus (VEE), an alphavirus, were configured as candidate vaccines for Ebola…”
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Candidate Vaccine against Botulinum Neurotoxin Serotype A Derived from a Venezuelan Equine Encephalitis Virus Vector System by LEE, John S, PUSHKO, Peter, PARKER, Michael D, DERTZBAUGH, Mark T, SMITH, Leonard A, SMITH, Jonathan F

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Plasmid DNA launches live-attenuated Japanese encephalitis virus and elicits virus-neutralizing antibodies in BALB/c mice by Nickols, Brian, Tretyakova, Irina, Tibbens, Alexander, Klyushnenkova, Elena, Pushko, Peter

“…We describe novel plasmid DNA that encodes the full-length Japanese encephalitis virus (JEV) genomic cDNA and launches live-attenuated JEV vaccine in vitro and…”
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Alphavirus vector-based replicon particles expressing multivalent cross-protective Lassa virus glycoproteins by Wang, Min, Jokinen, Jenny, Tretyakova, Irina, Pushko, Peter, Lukashevich, Igor S.

“…•High genetic diversity of LASV is one of the great challenges for vaccine R&D.•VEEV TC-83 vaccine was used to design bivalent virus-like-particle-vectors,…”
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DNA Vaccine Initiates Replication of Live Attenuated Chikungunya Virus In Vitro and Elicits Protective Immune Response in Mice by Tretyakova, Irina, Hearn, Jason, Wang, Eryu, Weaver, Scott, Pushko, Peter

“…Background. Chikungunya virus (CHIKV) causes outbreaks of chikungunya fever worldwide and represents an emerging pandemic threat. Vaccine development against…”
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