The role of radiation and non-radiation factors in the development and progression of acute leukemia in children

At 278 ALL and AML patients the kind of hereditary pathology in the family; clinikal-laboratory features and a course of acute leukemia and terms of longevity of children were studied. Degree of integrated pollution of territory (air, water, soil) by heavy metals and radionuclides and also the irrad...

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Bibliographic Details
Published in:	Likars'ka sprava no. 8; p. 29
Main Authors:	Bebeshko, V H, Bruslova, K M, Kuznietsova, O É, Tsvietkova, N M, Honchar, L O, Iatsemyrs'kyĭ, S M, Samson, Iu M, Pushkar'ova, T I
Format:	Journal Article
Language:	Ukrainian
Published:	Ukraine 01-12-2012
Subjects:	Adolescent Chernobyl Nuclear Accident Child Child, Preschool Disease Progression Environmental Pollution - adverse effects Female Health Status Indicators Hematopoiesis - drug effects Hematopoietic System - drug effects Hematopoietic System - pathology Heredity Humans Infant Infant, Newborn Leukemia, Myeloid, Acute - etiology Leukemia, Myeloid, Acute - genetics Leukemia, Myeloid, Acute - mortality Leukemia, Myeloid, Acute - pathology Male Metals, Heavy - toxicity Precursor Cell Lymphoblastic Leukemia-Lymphoma - etiology Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics Precursor Cell Lymphoblastic Leukemia-Lymphoma - mortality Precursor Cell Lymphoblastic Leukemia-Lymphoma - pathology Radioisotopes - toxicity Risk Factors Survival Analysis
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Summary:	At 278 ALL and AML patients the kind of hereditary pathology in the family; clinikal-laboratory features and a course of acute leukemia and terms of longevity of children were studied. Degree of integrated pollution of territory (air, water, soil) by heavy metals and radionuclides and also the irradiation doses have been considered. Results which have been received testify about the certain contribution of genetic components and adverse factors of environment in of development of acute leukemia and their course at children. The definition of different leukemogenic factors action on the condition of hemopoietic system gives the chance to generate the abnormally high risk groups of oncological hematological pathologies among the children's population and to improve the diagnostic and treatment-and-prophylactic actions.
ISSN:	1019-5297