Search Results - "Purves, J. Todd"

A highly polarized TH2 bladder response to infection promotes epithelial repair at the expense of preventing new infections by Wu, Jianxuan, Hayes, Byron W., Phoenix, Cassandra, Macias, Gustavo Sosa, Miao, Yuxuan, Choi, Hae Woong, Hughes, Francis M., Todd Purves, J., Lee Reinhardt, R., Abraham, Soman N.

“…Urinary tract infections (UTIs) typically evoke prompt and vigorous innate bladder immune responses, including extensive exfoliation of the epithelium. To…”
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Sexual Function and Dysfunction in Individuals with Spina Bifida: A Systematic Review by Hughes, Taylor L., Simmons, Kirsten L., Tejwani, Rohit, Barton, Karen D., Wiener, John S., Todd Purves, J., Routh, Jonathan C.

“…To conduct a systematic review of self-reported experiences of sexual function and dysfunction in individuals with spina bifida (SB). Medline, Embase, and Web…”
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Bladder fibrosis during outlet obstruction is triggered through the NLRP3 inflammasome and the production of IL-1β by Hughes, Jr, Francis M, Sexton, Stephanie J, Jin, Huixia, Govada, Vihasa, Purves, J Todd

“…Bladder outlet obstruction (BOO) triggers inflammation in the bladder through the NLRP3 inflammasome. BOO also activates fibrosis, which is largely responsible…”
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Strict glucose control and elimination of NLRP3‐induced inflammation prevents diabetic bladder dysfunction in the female Akita mouse model by Hughes, Francis M., Harper, Shelby N., Jin, Huixia, Odom, Michael R., Purves, J. Todd

“…Purpose Diabetic bladder dysfunction (DBD) is the most common diabetic complication. Logically, regulation of blood glucose should reverse dysfunction, but the…”
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Diabetic bladder dysfunction progresses from an overactive to an underactive phenotype in a type-1 diabetic mouse model (Akita female mouse) and is dependent on NLRP3 by Hughes, Francis M., Allkanjari, Armand, Odom, Michael R., Jin, Huixia, Purves, J. Todd

“…Diabetic bladder dysfunction (DBD) is a prevalent diabetic complication thought to progress from overactive (OAB) to underactive (UAB) bladder. Previously we…”
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Why Are Some People with Lower Urinary Tract Symptoms (LUTS) Depressed? New Evidence That Peripheral Inflammation in the Bladder Causes Central Inflammation and Mood Disorders by Hughes, Jr, Francis M, Odom, Michael R, Cervantes, Anissa, Livingston, Austin J, Purves, J Todd

“…Anecdotal evidence has long suggested that patients with lower urinary tract symptoms (LUTS) develop mood disorders, such as depression and anxiety, at a…”
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Patient education and extracorporeal membrane oxygenation preferences of patients and providers in COVID care by Borre, Ethan D, Maciejewski, Matthew L, Fink, Arlene, Burnside, Melissa, Purves, J Todd, Scales, Jr, Charles D, Fan, Eddy, Sandhu, Bhawandip, Pignone, Kevin, Palmer, Caroline, Webb, Carrington, Guggenheim, Dana S, Zhang, Yuqi

“…Extracorporeal membrane oxygenation (ECMO) represents an important but limited treatment for patients with severe COVID-19. We assessed the effects of an…”
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Evaluation of Poly (Carbonate-Urethane) Urea (PCUU) Scaffolds for Urinary Bladder Tissue Engineering by Sivaraman, Srikanth, Amoroso, Nicholas, Gu, Xinzhu, Purves, J. Todd, Hughes, Francis M., Wagner, William R., Nagatomi, Jiro

“…Although the previous success of bladder tissue engineering demonstrated the feasibility of this technology, most polyester based scaffolds used in previous…”
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Inflammasomes in the urinary tract: a disease-based review by Purves, J Todd, Hughes, Jr, F Monty

“…Inflammasomes are supramolecular structures that sense molecular patterns from pathogenic organisms or damaged cells and trigger an innate immune response,…”
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Specialized pro-resolution mediators in the bladder: effects of resolvin E1 on diabetic bladder dysfunction in the type 1 diabetic male Akita mouse model by Cervantes, Anissa, Hughes, Jr, Francis M, Jin, Huixia, Purves, J Todd

“…One of the most common, but least studied, diabetic complication is diabetic bladder dysfunction. Current therapies include glucose control and symptom-based…”
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NLRP3 Promotes Diabetic Bladder Dysfunction and Changes in Symptom-Specific Bladder Innervation by Hughes, Jr, Francis M, Hirshman, Nathan A, Inouye, Brian M, Jin, Huixia, Stanton, Eloise W, Yun, Chloe E, Davis, Leah G, Routh, Jonathan C, Purves, J Todd

“…The NLRP3 inflammasome senses diabetic metabolites and initiates inflammation implicated in diabetic complications and neurodegeneration. No studies have…”
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Elevated hydrostatic pressure stimulates ATP release which mediates activation of the NLRP3 inflammasome via P2X4 in rat urothelial cells by Dunton, Cody L., Purves, J. Todd, Hughes, Francis M., Jin, Huixia, Nagatomi, Jiro

“…Partial bladder outlet obstruction (pBOO) is a prevalent urological condition commonly accompanied by increased intravesical pressure, inflammation, and…”
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Pediatric Neurogenic Bladder and Bowel Dysfunction: Will My Child Ever Be out of Diapers? by Johnston, Ashley W., Wiener, John S., Todd Purves, J.

“…Managing patient and parent expectations regarding urinary and fecal continence is important with congenital conditions that produce neurogenic bladder and…”
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BOO induces fibrosis and EMT in urothelial cells which can be recapitulated in vitro through elevated storage and voiding pressure cycles by Dunton, Cody L., Purves, J. Todd, Hughes, Francis M., Nagatomi, Jiro

“…Purpose To determine the unique contributions from elevated voiding and storage pressures in the development of fibrosis and the epithelial-to-mesenchymal…”
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A novel urodynamic model for lower urinary tract assessment in awake rats by Schneider, Marc P., Hughes, Francis M., Engmann, Anne K., Purves, J. Todd, Kasper, Hansjörg, Tedaldi, Marco, Spruill, Laura S., Gullo, Miriam, Schwab, Martin E., Kessler, Thomas M.

“…Objectives To develop a urodynamic model incorporating external urethral sphincter (EUS) electromyography (EMG) in awake rats. Materials and Methods Bladder…”
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Inflammasomes are important mediators of cyclophosphamide-induced bladder inflammation by Hughes, Jr, Francis M, Vivar, Nivardo P, Kennis, James G, Pratt-Thomas, Jeffery D, Lowe, Danielle W, Shaner, Brooke E, Nietert, Paul J, Spruill, Laura S, Purves, J Todd

“…Bladder inflammation (cystitis) underlies numerous bladder pathologies and is elicited by a plethora of agents such as urinary tract infections, bladder outlet…”
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Female Type 1 Diabetic Akita Mice Demonstrate Increased Bladder Contractility via FP Receptor Activation due to NLRP3-Mediated Inflammation by Odom, Michael R, Hughes, Jr, Francis M, Pope, NiQuava, Jin, Huixia, Purves, J Todd

“…Diabetic bladder dysfunction (DBD) is driven in part by inflammation which dysregulates prostaglandin release in the bladder. Precise inflammatory mechanisms…”
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Association between race and in-hospital outcomes in children with spina bifida following inpatient urologic surgery by Chandrapal, Jason, Simmons, Kirsten, Purves, J Todd, Wiener, John S, Routh, Jonathan C

“…Post-operative complication rates may vary among racial and/or ethnic groups and have not been previously described in individuals with spina bifida (SB)…”
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The potential repertoire of the innate immune system in the bladder: expression of pattern recognition receptors in the rat bladder and a rat urothelial cell line (MYP3 cells) by Hughes, Francis M., Turner, David P., Todd Purves, J.

“…Purpose The urothelium is a frontline sensor of the lower urinary tract, sampling the bladder lumen and stimulating an immune response to infectious and…”
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Lower Urinary Tract Symptoms in Older Children With and Without Diabetes Mellitus by Kelly, Maryellen S., Routh, Jonathan C., Davis, Leah G., Purves, J. Todd, Wiener, John S., Maciejewski, Matthew L.

“…Lower urinary tract symptoms (LUTS) are an underrecognized complication of diabetes mellitus (DM) in adults and have undergone limited investigation in…”
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