Search Results - "Purushothaman, Anurag"

Fibronectin on the Surface of Myeloma Cell-derived Exosomes Mediates Exosome-Cell Interactions by Purushothaman, Anurag, Bandari, Shyam Kumar, Liu, Jian, Mobley, James A., Brown, Elizabeth E., Sanderson, Ralph D.

“…Exosomes regulate cell behavior by binding to and delivering their cargo to target cells; however, the mechanisms mediating exosome-cell interactions are…”
Get full text

Serglycin Proteoglycan Is Required for Multiple Myeloma Cell Adhesion, in Vivo Growth, and Vascularization by Purushothaman, Anurag, Toole, Bryan P.

“…Recently, it was discovered that serglycin, a hematopoietic cell proteoglycan, is the major proteoglycan expressed and constitutively secreted by multiple…”
Get full text

The heparanase/syndecan‐1 axis in cancer: mechanisms and therapies by Ramani, Vishnu C., Purushothaman, Anurag, Stewart, Mark D., Thompson, Camilla A., Vlodavsky, Israel, Au, Jessie L‐S., Sanderson, Ralph D.

“…Heparanase is an endoglucuronidase that cleaves heparan sulfate chains of proteoglycans. In many malignancies, high heparanase expression and activity…”
Get full text

Heparanase-enhanced shedding of syndecan-1 by myeloma cells promotes endothelial invasion and angiogenesis by Purushothaman, Anurag, Uyama, Toru, Kobayashi, Fumi, Yamada, Shuhei, Sugahara, Kazuyuki, Rapraeger, Alan C., Sanderson, Ralph D.

“…Heparanase enhances shedding of syndecan-1 (CD138), and high levels of heparanase and shed syndecan-1 in the tumor microenvironment are associated with…”
Get full text

Heparanase Stimulation of Protease Expression Implicates It as a Master Regulator of the Aggressive Tumor Phenotype in Myeloma by Purushothaman, Anurag, Chen, Ligong, Yang, Yang, Sanderson, Ralph D.

“…High levels of heparanase are an indicator of poor prognosis in myeloma patients, and up-regulation of the enzyme enhances tumor growth, angiogenesis, and…”
Get full text

Differential Effects of Pancreatic Cancer-Derived Extracellular Vesicles Driving a Suppressive Environment by Purushothaman, Anurag, Oliva-Ramírez, Jacqueline, Treekitkarnmongkol, Warapen, Sankaran, Deivendran, Hurd, Mark W, Putluri, Nagireddy, Maitra, Anirban, Haymaker, Cara, Sen, Subrata

“…Pancreatic ductal adenocarcinoma (PDAC) cells display extensive crosstalk with their surrounding environment to regulate tumor growth, immune evasion, and…”
Get full text

Chondroitin sulfate proteoglycan serglycin influences protein cargo loading and functions of tumor-derived exosomes by Purushothaman, Anurag, Bandari, Shyam K, Chandrashekar, Darshan S, Jones, Richard J, Lee, Hans C, Weber, Donna M, Orlowski, Robert Z

“…Tumor cells produce and utilize exosomes to promote tumor growth and metastasis. Tumor-cell-derived exosomes deliver cargos that partially mimic the contents…”
Get full text

Overexpression of Galnt3 in Chondrocytes Resulted in Dwarfism Due to the Increase of Mucin-type O-Glycans and Reduction of Glycosaminoglycans by Yoshida, Carolina Andrea, Kawane, Tetsuya, Moriishi, Takeshi, Purushothaman, Anurag, Miyazaki, Toshihiro, Komori, Hisato, Mori, Masako, Qin, Xin, Hashimoto, Ayako, Sugahara, Kazuyuki, Yamana, Kei, Takada, Kenji, Komori, Toshihisa

“…Galnt3, UDP-N-acetyl-α-d-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3, transfers N-acetyl-d-galactosamine to serine and threonine residues,…”
Get full text

Antibody GD3G7 Selected against Embryonic Glycosaminoglycans Defines Chondroitin Sulfate-E Domains Highly Up-Regulated in Ovarian Cancer and Involved in Vascular Endothelial Growth Factor Binding by ten Dam, Gerdy B, van de Westerlo, Els M.A, Purushothaman, Anurag, Stan, Radu V, Bulten, Johan, Sweep, Fred C.G.J, Massuger, Leon F, Sugahara, Kazuyuki, van Kuppevelt, Toin H

“…Chondroitin sulfate (CS) is abundantly present in the tumor stroma, and tumor-specific CS modifications might be potential targets to influence tumor…”
Get full text

Dermatan sulfate domains defined by the novel antibody GD3A12, in normal tissues and ovarian adenocarcinomas by ten Dam, Gerdy B, Yamada, Shuhei, Kobayashi, Fumi, Purushothaman, Anurag, van de Westerlo, Els M.A, Bulten, Johan, Malmström, Anders, Sugahara, Kazuyuki, Massuger, Leon F, van Kuppevelt, Toin H

“…Dermatan sulfate (DS) expression in normal tissue and ovarian cancer was investigated using the novel, phage display-derived antibody GD3A12 that was selected…”
Get full text

The role of glycans in the mechanobiology of cancer by Purushothaman, Anurag, Mohajeri, Mohammad, Lele, Tanmay P.

“…Although cancer is a genetic disease, physical changes such as stiffening of the extracellular matrix also commonly occur in cancer. Cancer cells sense and…”
Get full text

Functions of Chondroitin Sulfate/Dermatan Sulfate Chains in Brain Development by Purushothaman, Anurag, Fukuda, Junko, Mizumoto, Shuji, ten Dam, Gerdy B., van Kuppevelt, Toin H., Kitagawa, Hiroshi, Mikami, Tadahisa, Sugahara, Kazuyuki

“…Chondroitin sulfate (CS) and dermatan sulfate (DS) have been implicated in the processes of neural development in the brain. In this study, we characterized…”
Get full text

Chondroitin Sulfate “Wobble Motifs” Modulate Maintenance and Differentiation of Neural Stem Cells and Their Progeny by Purushothaman, Anurag, Sugahara, Kazuyuki, Faissner, Andreas

“…Chondroitin sulfate/dermatan sulfate (CS/DS) proteoglycans, major components of the central nervous system, have the potential to interact with a wide range of…”
Get full text

Heparanase Regulates Secretion, Composition, and Function of Tumor Cell-derived Exosomes by Thompson, Camilla A., Purushothaman, Anurag, Ramani, Vishnu C., Vlodavsky, Israel, Sanderson, Ralph D.

“…Emerging evidence indicates that exosomes play a key role in tumor-host cross-talk and that exosome secretion, composition, and functional capacity are altered…”
Get full text

Heparanase: A Dynamic Promoter of Myeloma Progression by Purushothaman, Anurag, Sanderson, Ralph D

“…It has been speculated for many years that heparanase plays an important role in the progression of cancer due largely to the finding that its expression is…”
Get more information

Chemotherapy induces secretion of exosomes loaded with heparanase that degrades extracellular matrix and impacts tumor and host cell behavior by Bandari, Shyam K., Purushothaman, Anurag, Ramani, Vishnu C., Brinkley, Garrett J., Chandrashekar, Darshan S., Varambally, Sooryanarayana, Mobley, James A., Zhang, Yi, Brown, Elizabeth E., Vlodavsky, Israel, Sanderson, Ralph D.

“…The heparan sulfate-degrading enzyme heparanase promotes the progression of many cancers by driving tumor cell proliferation, metastasis and angiogenesis…”
Get full text

Heparanase-mediated Loss of Nuclear Syndecan-1 Enhances Histone Acetyltransferase (HAT) Activity to Promote Expression of Genes That Drive an Aggressive Tumor Phenotype by Purushothaman, Anurag, Hurst, Douglas R., Pisano, Claudio, Mizumoto, Shuji, Sugahara, Kazuyuki, Sanderson, Ralph D.

“…Heparanase acts as a master regulator of the aggressive tumor phenotype in part by enhancing expression of proteins known to drive tumor progression (e.g…”
Get full text

Abstract A17: Glycosaminoglycans regulates histone acetylation status in multiple myeloma by Purushothaman, Anurag, Sanderson, Ralph D.

“…Abstract Histone acetylation modulates gene expression, cellular differentiation, and cell survival and is regulated by the opposing activities of histone…”
Get full text

Heparanase Enhances the Insulin Receptor Signaling Pathway to Activate Extracellular Signal-regulated Kinase in Multiple Myeloma by Purushothaman, Anurag, Babitz, Stephen K., Sanderson, Ralph D.

“…ERK signaling regulates proliferation, survival, drug resistance, and angiogenesis in cancer. Although the mechanisms regulating ERK activation are not fully…”
Get full text

Analysis of B7-H4 Expression Across Salivary Gland Carcinomas Reveals Adenoid Cystic Carcinoma-Specific Prognostic Relevance by Siqueira, Juliana Mota, Mitani, Yoshitsugu, Hoff, Camilla Oliveira, Bonini, Flavia, Guimaraes de Sousa, Luana, Marques-Piubelli, Mario L, Purushothaman, Anurag, Mitani, Mutsumi, Dai, Hui, Lin, Shiaw-Yih, Spiotto, Michael T, Hanna, Ehab Y, McGrail, Daniel J, El-Naggar, Adel K, Ferrarotto, Renata

“…B7-H4 (VTCN1), a member of the B7 family, is overexpressed in several types of cancer. Here we investigated the pattern of expression of B7-H4 in salivary…”
Get full text