Search Results - "Pursiheimo, Juha"

Gut Microbiota Analysis Results Are Highly Dependent on the 16S rRNA Gene Target Region, Whereas the Impact of DNA Extraction Is Minor by Rintala, Anniina, Pietilä, Sami, Munukka, Eveliina, Eerola, Erkki, Pursiheimo, Juha-Pekka, Laiho, Asta, Pekkala, Satu, Huovinen, Pentti

“…Next-generation sequencing (NGS) is currently the method of choice for analyzing gut microbiota composition. As gut microbiota composition is a potential…”
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ANO7 is associated with aggressive prostate cancer by Kaikkonen, Elina, Rantapero, Tommi, Zhang, Qin, Taimen, Pekka, Laitinen, Virpi, Kallajoki, Markku, Jambulingam, Dhanaprakash, Ettala, Otto, Knaapila, Juha, Boström, Peter J., Wahlström, Gudrun, Sipeky, Csilla, Pursiheimo, Juha‐Pekka, Tammela, Teuvo, Kellokumpu‐Lehtinen, Pirkko‐Liisa, Fey, Vidal, Maehle, Lovise, Wiklund, Fredrik, Wei, Gong‐Hong, Schleutker, Johanna

“…Prostate cancer is one of the most common and heritable human cancers. Our aim was to find germline biomarkers that can predict disease outcome. We previously…”
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Gut virome sequencing in children with early islet autoimmunity by Kramná, Lenka, Kolářová, Kateřina, Oikarinen, Sami, Pursiheimo, Juha-Pekka, Ilonen, Jorma, Simell, Olli, Knip, Mikael, Veijola, Riitta, Hyöty, Heikki, Cinek, Ondrej

“…This study used next-generation sequencing (NGS) technologies to characterize the gut virome at the onset of islet autoimmunity. We conducted a case-control…”
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The interactome of the prostate-specific protein Anoctamin 7 by Kaikkonen, Elina, Takala, Aliisa, Pursiheimo, Juha-Pekka, Wahlström, Gudrun, Schleutker, Johanna

“…Elevated Anoctamin 7 (ANO7) expression is associated with poor survival in prostate cancer patients. The aim was to discover proteins that interact with ANO7…”
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An effective combination of sanger and next generation sequencing in diagnostics of primary ciliary dyskinesia by Djakow, Jana, Kramná, Lenka, Dušátková, Lenka, Uhlík, Jiří, Pursiheimo, Juha-Pekka, Svobodová, Tamara, Pohunek, Petr, Cinek, Ondřej

“…Summary Background Primary ciliary dyskinesia (PCD) is a multigenic autosomal recessive condition affecting respiratory tract and other organs where ciliary…”
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Promoter-specific alterations of APC are a rare cause for mutation-negative familial adenomatous polyposis by Pavicic, Walter, Nieminen, Taina T., Gylling, Annette, Pursiheimo, Juha-Pekka, Laiho, Asta, Gyenesei, Attila, Järvinen, Heikki J., Peltomäki, Päivi

“…In familial adenomatous polyposis (FAP), 20% of classical and 70% of attenuated/atypical (AFAP) cases remain mutation‐negative after routine testing; yet,…”
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RNA-Binding Protein L1TD1 Interacts with LIN28 via RNA and is Required for Human Embryonic Stem Cell Self-Renewal and Cancer Cell Proliferation by Närvä, Elisa, Rahkonen, Nelly, Emani, Maheswara Reddy, Lund, Riikka, Pursiheimo, Juha-Pekka, Nästi, Juuso, Autio, Reija, Rasool, Omid, Denessiouk, Konstantin, Lähdesmäki, Harri, Rao, Anjana, Lahesmaa, Riitta

“…Human embryonic stem cells (hESC) have a unique capacity to self‐renew and differentiate into all the cell types found in human body. Although the…”
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Detection of Novel Gene Variants Associated with Congenital Hypothyroidism in a Finnish Patient Cohort by Löf, Christoffer, Patyra, Konrad, Kuulasmaa, Teemu, Vangipurapu, Jagadish, Undeutsch, Henriette, Jaeschke, Holger, Pajunen, Tuulia, Kero, Andreina, Krude, Heiko, Biebermann, Heike, Kleinau, Gunnar, Kühnen, Peter, Rantakari, Krista, Miettinen, Päivi, Kirjavainen, Turkka, Pursiheimo, Juha-Pekka, Mustila, Taina, Jääskeläinen, Jarmo, Ojaniemi, Marja, Toppari, Jorma, Ignatius, Jaakko, Laakso, Markku, Kero, Jukka

“…Congenital hypothyroidism (CH) is defined as the lack of thyroid hormones at birth. Mutations in at least 15 different genes have been associated with this…”
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Early fecal microbiota composition in children who later develop celiac disease and associated autoimmunity by Rintala, Anniina, Riikonen, Iiris, Toivonen, Anne, Pietilä, Sami, Munukka, Eveliina, Pursiheimo, Juha-Pekka, Elo, Laura L, Arikoski, Pekka, Luopajärvi, Kristiina, Schwab, Ursula, Uusitupa, Matti, Heinonen, Seppo, Savilahti, Erkki, Eerola, Erkki, Ilonen, Jorma

“…Several studies have reported that the intestinal microbiota composition of celiac disease (CD) patients differs from healthy individuals. The possible role of…”
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Gene Expression Differences between Noccaea caerulescens Ecotypes Help to Identify Candidate Genes for Metal Phytoremediation by Halimaa, Pauliina, Lin, Ya-Fen, Ahonen, Viivi H, Blande, Daniel, Clemens, Stephan, Gyenesei, Attila, Häikiö, Elina, Kärenlampi, Sirpa O, Laiho, Asta, Aarts, Mark G. M, Pursiheimo, Juha-Pekka, Schat, Henk, Schmidt, Holger, Tuomainen, Marjo H, Tervahauta, Arja I

“…Populations of Noccaea caerulescens show tremendous differences in their capacity to hyperaccumulate and hypertolerate metals. To explore the differences that…”
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Neuropeptide Y Overexpressing Female and Male Mice Show Divergent Metabolic but Not Gut Microbial Responses to Prenatal Metformin Exposure by Salomäki-Myftari, Henriikka, Vähätalo, Laura H, Ailanen, Liisa, Pietilä, Sami, Laiho, Asta, Hänninen, Arno, Pursiheimo, Juha-Pekka, Munukka, Eveliina, Rintala, Anniina, Savontaus, Eriika, Pesonen, Ullamari, Koulu, Markku

“…Prenatal metformin exposure has been shown to improve the metabolic outcome in the offspring of high fat diet fed dams. However, if this is evident also in a…”
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Genetic Variants of Gonadotropins and Their Receptors Could Influence Controlled Ovarian Stimulation: IVF Data from a Prospective Multicenter Study by Alviggi, Carlo, Longobardi, Salvatore, Papaleo, Enrico, Santi, Daniele, Alfano, Simona, Vanni, Valeria Stella, Campitiello, Maria Rosaria, De Rosa, Pasquale, Strina, Ida, Huhtaniemi, Ilpo, Pursiheimo, Juha-Pekka, D'Hooghe, Thomas, Humaidan, Peter, Conforti, Alessandro

“…Specific polymorphisms might influence controlled ovarian stimulation in women undergoing assisted reproductive technologies (ARTs). Data regarding possible…”
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Fermentable fibres condition colon microbiota and promote diabetogenesis in NOD mice by Toivonen, Raine K., Emani, Rohini, Munukka, Eveliina, Rintala, Anniina, Laiho, Asta, Pietilä, Sami, Pursiheimo, Juha-Pekka, Soidinsalo, Pasi, Linhala, Mari, Eerola, Erkki, Huovinen, Pentti, Hänninen, Arno

“…Aims/hypothesis Gut microbiota (GM) and diet both appear to be important in the pathogenesis of type 1 diabetes. Fermentable fibres (FFs), of which there is an…”
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Continuous hypoxic culturing of human embryonic stem cells enhances SSEA-3 and MYC levels by Närvä, Elisa, Pursiheimo, Juha-Pekka, Laiho, Asta, Rahkonen, Nelly, Emani, Maheswara Reddy, Viitala, Miro, Laurila, Kirsti, Sahla, Roosa, Lund, Riikka, Lähdesmäki, Harri, Jaakkola, Panu, Lahesmaa, Riitta

“…Low oxygen tension (hypoxia) contributes critically to pluripotency of human embryonic stem cells (hESCs) by preventing spontaneous differentiation and…”
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Transcriptomics and mechanistic elucidation of Alzheimer's disease risk genes in the brain and in vitro models by Martiskainen, Henna, Viswanathan, Jayashree, Nykänen, Niko-Petteri, Kurki, Mitja, Helisalmi, Seppo, Natunen, Teemu, Sarajärvi, Timo, Kurkinen, Kaisa M.A, Pursiheimo, Juha-Pekka, Rauramaa, Tuomas, Alafuzoff, Irina, Jääskeläinen, Juha E, Leinonen, Ville, Soininen, Hilkka, Haapasalo, Annakaisa, Huttunen, Henri J, Hiltunen, Mikko

“…Abstract In this study, we have assessed the expression and splicing status of genes involved in the pathogenesis or affecting the risk of Alzheimer's disease…”
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Next generation sequencing of all variable loops of synthetic single framework scFv—Application in anti-HDL antibody selections by Lövgren, Janita, Pursiheimo, Juha-Pekka, Pyykkö, Mikko, Salmi, Jussi, Lamminmäki, Urpo

“…•Method for sequencing all CDRs of scFv from a synthetic single framework library with Illumina MiSeq.•Simple software for analyzing the CDR sequences and read…”
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Aging and serum exomiR content in women-effects of estrogenic hormone replacement therapy by Kangas, Reeta, Törmäkangas, Timo, Fey, Vidal, Pursiheimo, Juha, Miinalainen, Ilkka, Alen, Markku, Kaprio, Jaakko, Sipilä, Sarianna, Säämänen, Anna-Marja, Kovanen, Vuokko, Laakkonen, Eija K.

“…Exosomes participate in intercellular messaging by transporting bioactive lipid-, protein- and RNA-molecules and -complexes. The contents of the exosomes…”
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Relationship between ubiquilin-1 and BACE1 in human Alzheimer's disease and APdE9 transgenic mouse brain and cell-based models by Natunen, Teemu, Takalo, Mari, Kemppainen, Susanna, Leskelä, Stina, Marttinen, Mikael, Kurkinen, Kaisa M.A, Pursiheimo, Juha-Pekka, Sarajärvi, Timo, Viswanathan, Jayashree, Gabbouj, Sami, Solje, Eino, Tahvanainen, Eveliina, Pirttimäki, Tiina, Kurki, Mitja, Paananen, Jussi, Rauramaa, Tuomas, Miettinen, Pasi, Mäkinen, Petra, Leinonen, Ville, Soininen, Hilkka, Airenne, Kari, Tanzi, Rudolph E, Tanila, Heikki, Haapasalo, Annakaisa, Hiltunen, Mikko

“…Abstract Accumulation of β-amyloid (Aβ) and phosphorylated tau in the brain are central events underlying Alzheimer's disease (AD) pathogenesis. Aβ is…”
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p62 degradation by autophagy: Another way for cancer cells to survive under hypoxia by Jaakkola, Panu M., Pursiheimo, Juha-Pekka

“…Hypoxia is a common feature of advanced solid tumors causing cancer progression and resistance to treatment. Hypoxia activates mitophagy as well as…”
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Multiple targets identified with genome wide profiling of small RNA and mRNA expression are linked to fracture healing in mice by Bourgery, Matthieu, Ekholm, Erika, Fagerlund, Katja, Hiltunen, Ari, Puolakkainen, Tero, Pursiheimo, Juha-Pekka, Heino, Terhi, Määttä, Jorma, Heinonen, Jussi, Yatkin, Emrah, Laitala, Tiina, Säämänen, Anna-Marja

“…Long-bone fracture is a common injury and its healing process at the fracture site involves several overlapping phases, including inflammation, migration of…”
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