Search Results - "Purro, A"

Dysfunction of Wnt signaling and synaptic disassembly in neurodegenerative diseases by Purro, Silvia A, Galli, Soledad, Salinas, Patricia C

“…The molecular mechanisms that regulate synapse formation have been well documented. However, little is known about the factors that modulate synaptic…”
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Two mouse models of Alzheimer’s disease accumulate amyloid at different rates and have distinct Aβ oligomer profiles unaltered by ablation of cellular prion protein by Purro, Silvia A., Farmer, Michael, Noble, Elizabeth, Sarell, Claire J., Powell, Megan, Yip, Daniel, Giggins, Lauren, Zakka, Leila, Thomas, David X., Farrow, Mark, Nicoll, Andrew J., Walsh, Dominic, Collinge, John

“…Oligomers formed from monomers of the amyloid β-protein (Aβ) are thought to be central to the pathogenesis of Alzheimer’s disease (AD). Unsurprisingly for a…”
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Wnt Regulates Axon Behavior through Changes in Microtubule Growth Directionality: A New Role for Adenomatous Polyposis Coli by Purro, Silvia A, Ciani, Lorenza, Hoyos-Flight, Monica, Stamatakou, Eleanna, Siomou, Eliza, Salinas, Patricia C

“…Axon guidance and target-derived signals control axonal behavior by regulating the cytoskeleton through poorly defined mechanisms. In particular, how these…”
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Prion Protein as a Toxic Acceptor of Amyloid-β Oligomers by Purro, Silvia A., Nicoll, Andrew J., Collinge, John

“…The initial report that cellular prion protein (PrPC) mediates toxicity of amyloid-β species linked to Alzheimer’s disease was initially treated with…”
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The secreted Wnt antagonist Dickkopf-1 is required for amyloid β-mediated synaptic loss by Purro, Silvia A, Dickins, Ellen M, Salinas, Patricia C

“…Extensive evidence supports a central role for amyloid-β (Aβ) in the pathogenesis of Alzheimer's disease (AD). Synaptic loss mediated by Aβ in early stages of…”
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Transmission of amyloid-β protein pathology from cadaveric pituitary growth hormone by Purro, Silvia A., Farrow, Mark A., Linehan, Jacqueline, Nazari, Tamsin, Thomas, David X., Chen, Zhicheng, Mengel, David, Saito, Takashi, Saido, Takaomi, Rudge, Peter, Brandner, Sebastian, Walsh, Dominic M., Collinge, John

“…We previously reported 1 the presence of amyloid-β protein (Aβ) deposits in individuals with Creutzfeldt–Jakob disease (CJD) who had been treated during…”
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mGlu5 receptors and cellular prion protein mediate amyloid-β-facilitated synaptic long-term depression in vivo by Hu, Neng-Wei, Nicoll, Andrew J., Zhang, Dainan, Mably, Alexandra J., O’Malley, Tiernan, Purro, Silvia A., Terry, Cassandra, Collinge, John, Walsh, Dominic M., Rowan, Michael J.

“…NMDA-type glutamate receptors (NMDARs) are currently regarded as paramount in the potent and selective disruption of synaptic plasticity by Alzheimer’s disease…”
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Reply to: Intrinsic Toxicity of Antibodies to the Globular Domain of the Prion Protein by Purro, Silvia A., Mead, Simon, Khalili-Shirazi, Azadeh, Nicoll, Andrew J., Collinge, John

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Partitioning of inspiratory muscle workload and pressure assistance in ventilator-dependent COPD patients by Appendini, L, Purro, A, Patessio, A, Zanaboni, S, Carone, M, Spada, E, Donner, C F, Rossi, A

“…To investigate the mechanisms underlying ventilator-dependence in patients with chronic obstructive pulmonary disease (COPD), and to assess the effects of the…”
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Post-Translational Incorporation of L-Phenylalanine into the C-Terminus of α-Tubulin as a Possible Cause of Neuronal Dysfunction by Ditamo, Yanina, Dentesano, Yanela M., Purro, Silvia A., Arce, Carlos A., Bisig, C. Gastón

“…α-Tubulin C-terminus undergoes post-translational, cyclic tyrosination/detyrosination, and L-Phenylalanine (Phe) can be incorporated in place of tyrosine…”
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Diaphragm fatigue during exercise at high altitude: the role of hypoxia and workload by Gudjonsdottir, M, Appendini, L, Baderna, P, Purro, A, Patessio, A, Vilianis, G, Pastorelli, M, Sigurdsson, S.B, Donner, C.F

“…The effect of high altitude (HA) on exercise-induced diaphragm fatigue in normal subjects was examined. Eight normal subjects completed an incremental exercise…”
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Post-translational incorporation of the antiproliferative agent azatyrosine into the C-terminus of alpha-tubulin by Purro, Silvia A, Bisig, C Gastón, Contin, María A, Barra, Héctor S, Arce, Carlos A

“…Detyrosination/tyrosination of tubulin is a post-translational modification that occurs at the C-terminus of the alpha-subunit, giving rise to microtubules…”
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Phytoremediation of 2,4-dichlorophenol using wild type and transgenic tobacco plants by Talano, Melina A., Busso, Débora C., Paisio, Cintia E., González, Paola S., Purro, Silvia A., Medina, María I., Agostini, Elizabeth

“…Introduction Transgenic plant strategies based on peroxidase expression or overexpression would be useful for phenolic compound removal since these enzymes…”
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Comparison of invasive and noninvasive saturation monitoring in prescribing oxygen during exercise in COPD patients by Carone, M, Patessio, A, Appendini, L, Purro, A, Czernicka, E, Zanaboni, S, Donner, CF

“…The aim of this study was to determine whether it is possible using ear-oximetry to prescribe the correct oxygen flow rates during exercise in chronic…”
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Tubulin must be acetylated in order to form a complex with membrane Na⁺,K⁺-ATPase and to inhibit its enzyme activity by Santander, Verónica S, Bisig, C. Gastón, Purro, Silvia A, Casale, César H, Arce, Carlos A, Barra, Héctor S

“…In cells of neural and non-neural origin, tubulin forms a complex with plasma membrane Na⁺,K⁺-ATPase, resulting in inhibition of the enzyme activity. When…”
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Lack of stabilized microtubules as a result of the absence of major maps in CAD cells does not preclude neurite formation by Bisig, C. Gastón, Chesta, María E, Zampar, Guillermo G, Purro, Silvia A, Santander, Verónica S, Arce, Carlos A

“…In many laboratories, the requirement of microtubule-associated proteins (MAPs) and the stabilization of microtubules for the elongation of neurites has been…”
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Incorporation of 3‐nitrotyrosine into the C‐terminus of α‐tubulin is reversible and not detrimental to dividing cells by Bisig, C. Gastón, Purro, Silvia A., Contín, María A., Barra, Héctor S., Arce, Carlos A.

“…The C‐terminus of the α‐chain of tubulin is subject to reversible incorporation of tyrosine by tubulin tyrosine ligase and removal by tubulin carboxypeptidase…”
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Inhibitors of protein phosphatase 1 and 2A decrease the level of tubulin carboxypeptidase activity associated with microtubules by Contín, María A., Purro, Silvia A., Bisig, C. Gastón, Barra, Héctor S., Arce, Carlos A.

“…The association of tubulin carboxypeptidase with microtubules may be involved in the determination of the tyrosination state of the microtubules, i.e. their…”
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Intermediate respiratory care unit: admission criteria by Zanaboni, S, Patessio, A, Purro, A, Appendini, L, Donner, C F

“…Intensive care unit (ICU) management of patients on partial ventilatory support is very costly. We opened an intermediate respiratory care unit (RCU), with the…”
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Physiologic determinants of ventilator dependence in long-term mechanically ventilated patients by PURRO, A, APPENDINI, L, DE GAETANO, A, GUDJONSDOTTIR, M, DONNER, C. F, ROSSI, A

“…To investigate the pathophysiologic mechanisms of ventilator dependence, we took physiologic measurements in 28 patients with COPD and 11 postcardiac surgery…”
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