Search Results - "Purohit, Vandana"

Mechanisms That Prevent Template Inactivation by HIV-1 Reverse Transcriptase RNase H Cleavages by Purohit, Vandana, Roques, Bernard P., Kim, Baek, Bambara, Robert A.

“…The RNase H activity of human immunodeficiency virus, type 1 (HIV-1) reverse transcriptase (RT) cleaves the viral genome concomitant with minus strand…”
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Reduced dNTP Binding Affinity of 3TC-resistant M184I HIV-1 Reverse Transcriptase Variants Responsible for Viral Infection Failure in Macrophage by Jamburuthugoda, Varuni K, Santos-Velazquez, Jose M., Skasko, Mark, Operario, Darwin J., Purohit, Vandana, Chugh, Pauline, Szymanski, Erika A., Wedekind, Joseph E., Bambara, Robert A., Kim, Baek

“…We characterized HIV-1 reverse transcriptase (RT) variants either with or without the (-)-2′,3′-deoxy-3′-thiacytidine-resistant M184I mutation isolated from a…”
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Fingers-Closing and Other Rapid Conformational Changes in DNA Polymerase I (Klenow Fragment) and Their Role in Nucleotide Selectivity by Joyce, Catherine M, Potapova, Olga, DeLucia, Angela M, Huang, Xuanwei, Basu, Vandana Purohit, Grindley, Nigel D. F

“…We have developed a FRET-based assay for the fingers-closing conformational transition that occurs when a binary complex of DNA polymerase I (Klenow fragment)…”
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Mutagenicity of Nitroaromatic Compounds by Purohit, Vandana, Basu, Ashis K

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Strand transfer events during HIV-1 reverse transcription by Basu, Vandana Purohit, Song, Min, Gao, Lu, Rigby, Sean T., Hanson, Mark Nils, Bambara, Robert A.

“…Human immunodeficiency virus type 1 (HIV-1) and other retroviruses replicate through reverse transcription, a process in which the single stranded RNA of the…”
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Use of 2-Aminopurine Fluorescence To Examine Conformational Changes during Nucleotide Incorporation by DNA Polymerase I (Klenow Fragment) by Purohit, Vandana, Grindley, Nigel D. F, Joyce, Catherine M

“…We have investigated conformational transitions in the Klenow fragment polymerase reaction by stopped-flow fluorescence using DNA substrates containing the…”
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Lagging Strand Replication Proteins in Genome Stability and DNA Repair by Rossi, Marie L, Purohit, Vandana, Brandt, Patrick D, Bambara, Robert A

“…The way polymerases interact with carcinogen-bound DNA is discussed. Many of the lagging strand proteins have evolved dual roles in DNA replication and repair…”
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Evidence That HIV-1 Reverse Transcriptase Employs the DNA 3′ End-directed Primary/Secondary RNase H Cleavage Mechanism during Synthesis and Strand Transfer by Vandana Purohit, Mini Balakrishnan, Baek Kim, Robert A. Bambara

“…We previously analyzed strand transfers catalyzed by human immunodeficiency virus, type 1 reverse transcriptase (RT) in a hairpin-containing RNA template…”
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Evidence That HIV-1 Reverse Transcriptase Employs the DNA 3′ End-directed Primary/Secondary RNase H Cleavage Mechanism during Synthesis and Strand Transfer by Purohit, Vandana, Balakrishnan, Mini, Kim, Baek, Bambara, Robert A.

“…We previously analyzed strand transfers catalyzed by human immunodeficiency virus, type 1 reverse transcriptase (RT) in a hairpin-containing RNA template…”
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Synthesis, characterization, and applications of oligonucleotides containing the major adducts derived from the carcinogenic nitropyrenes by Purohit, Vandana

“…Nitropolycylic aromatic hydrocarbons are environmental pollutants that have been detected in samples such as diesel fuel exhaust, coal fly ash and cigarette…”
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Photoassisted catalytic oxidation of alcohols and halogenated hydrocarbons with amorphous manganese oxides by Chen, Jie, Lin, Jung Chou, Purohit, Vandana, Cutlip, Michael B., Suib, Steven L.

“…This manuscript discusses the synthesis of Amorphous Manganese Oxide (AMO) materials that are used for efficient photoassisted catalytic oxidation of alcohols…”
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Synthesis and Characterization of Oligodeoxynucleotides Containing the Major DNA Adducts Formed by 1,6- and 1,8-Dinitropyrene by Purohit, Vandana, Basu, Ashis K

“…An efficient method for the synthesis of oligonucleotides containing a site-specific DNA adduct formed by the carcinogens 1,6- and 1,8-dinitropyrene has been…”
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Synthesis, characterization, and applications of oligonucleotides containing the major adducts derived from the carcinogenic nitropyrenes by Purohit, Vandana

“…Nitropolycylic aromatic hydrocarbons are environmental pollutants that have been detected in samples such as diesel fuel exhaust, coal fly ash and cigarette…”
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Differential Incision of Bulky Carcinogen−DNA Adducts by the UvrABC Nuclease:  Comparison of Incision Rates and the Interactions of Uvr Subunits with Lesions of Different Structures by Hoare, Sarasija, Zou, Yue, Purohit, Vandana, Krishnasamy, Ramji, Skorvaga, Milan, Van Houten, Bennett, Geacintov, Nicholas E, Basu, Ashis K

“…The UvrABC nuclease system from Escherichia coli removes DNA damages induced by a wide range of chemical carcinogens with variable efficiencies. The…”
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