Search Results - "Purnell, Benton"

Astrocyte-neuron circuits in epilepsy by Purnell, Benton S., Alves, Mariana, Boison, Detlev

“…The epilepsies are a diverse spectrum of disease states characterized by spontaneous seizures and associated comorbidities. Neuron-focused perspectives have…”
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Serotonin and sudden unexpected death in epilepsy by Petrucci, Alexandra N., Joyal, Katelyn G., Purnell, Benton S., Buchanan, Gordon F.

“…Epilepsy is a highly prevalent disease characterized by recurrent, spontaneous seizures. Approximately one-third of epilepsy patients will not achieve seizure…”
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Free-running circadian breathing rhythms are eliminated by suprachiasmatic nucleus lesion by Purnell, Benton S, Buchanan, Gordon F

“…It is widely agreed that breathing is subject to circadian regulation. Circadian differences in respiratory physiology significantly impact a number of…”
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Investigations into hydrogen sulfide-induced suppression of neuronal activity in vivo and calcium dysregulation in vitro by Kim, Dong-Suk, Pessah, Isaac N, Santana, Cristina M, Purnell, Benton S, Li, Rui, Buchanan, Gordon F, Rumbeiha, Wilson K

“…Abstract Acute exposure to high concentrations of hydrogen sulfide (H2S) leads to sudden death and, if survived, lingering neurological disorders. Clinical…”
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The Good, the Bad, and the Deadly: Adenosinergic Mechanisms Underlying Sudden Unexpected Death in Epilepsy by Purnell, Benton, Murugan, Madhuvika, Jani, Raja, Boison, Detlev

“…Adenosine is an inhibitory modulator of neuronal excitability. Neuronal activity results in increased adenosine release, thereby constraining excessive…”
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Effect of adenosinergic manipulations on amygdala‐kindled seizures in mice: Implications for sudden unexpected death in epilepsy by Purnell, Benton S., Petrucci, Alexandra N., Li, Rui, Buchanan, Gordon F.

“…Objective Sudden unexpected death in epilepsy (SUDEP) results in more years of potential life lost than any neurological condition with the exception of…”
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The effect of time‐of‐day and circadian phase on vulnerability to seizure‐induced death in two mouse models by Purnell, Benton S., Petrucci, Alexandra N., Li, Rui, Buchanan, Gordon F.

“…Key points Sudden unexpected death in epilepsy (SUDEP) is the leading cause of premature death in patients with refractory epilepsy. SUDEP typically occurs…”
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Dead in the Night: Sleep-Wake and Time-Of-Day Influences on Sudden Unexpected Death in Epilepsy by Purnell, Benton S, Thijs, Roland D, Buchanan, Gordon F

“…Sudden unexpected death in epilepsy (SUDEP) is the leading cause of epilepsy-related death in patients with refractory epilepsy. Convergent lines of evidence…”
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Time-of-day influences on respiratory sequelae following maximal electroshock-induced seizures in mice by Purnell, Benton S, Hajek, Michael A, Buchanan, Gordon F

“…Sudden unexpected death in epilepsy (SUDEP) is the leading cause of death in refractory epilepsy patients. Although specific mechanisms underlying SUDEP are…”
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The role of adenosine in alcohol-induced respiratory suppression by Purnell, Benton S., Thompson, Sydney, Bowman, Tenise, Bhasin, Jayant, George, Steven, Rust, Brian, Murugan, Madhuvika, Fedele, Denise, Boison, Detlev

“…Alcohol-related poisoning is the foremost cause of death resulting from excessive acute alcohol consumption. Respiratory failure is crucial to the…”
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Dorsal Raphe Serotonin Neurons Mediate CO2-Induced Arousal from Sleep by Smith, Haleigh R, Leibold, Nicole K, Rappoport, Daniel A, Ginapp, Callie M, Purnell, Benton S, Bode, Nicole M, Alberico, Stephanie L, Kim, Young-Cho, Audero, Enrica, Gross, Cornelius T, Buchanan, Gordon F

“…Arousal from sleep in response to CO 2 is a critical protective phenomenon. Dysregulation of CO 2 -induced arousal contributes to morbidity and mortality from…”
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Suppression of phrenic nerve activity as a potential predictor of imminent sudden unexpected death in epilepsy (SUDEP) by Ashraf, Omar, Huynh, Trong, Purnell, Benton S., Murugan, Madhuvika, Fedele, Denise E., Chitravanshi, Vineet, Boison, Detlev

“…Sudden unexpected death in epilepsy (SUDEP) is a leading cause of death in patients with refractory epilepsy. Centrally-mediated respiratory dysfunction has…”
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Dorsal Raphe Serotonin Neurons Mediate CO 2 -Induced Arousal from Sleep by Smith, Haleigh R, Leibold, Nicole K, Rappoport, Daniel A, Ginapp, Callie M, Purnell, Benton S, Bode, Nicole M, Alberico, Stephanie L, Kim, Young-Cho, Audero, Enrica, Gross, Cornelius T, Buchanan, Gordon F

“…Arousal from sleep in response to CO is a critical protective phenomenon. Dysregulation of CO -induced arousal contributes to morbidity and mortality from…”
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Effect of monoamine reuptake inhibition and α 1 blockade on respiratory arrest and death following electroshock-induced seizures in mice by Kruse, Stephen W, Dayton, Kyle G, Purnell, Benton S, Rosner, Jared I, Buchanan, Gordon F

“…Sudden unexpected death in epilepsy (SUDEP) is the leading cause of death in patients with refractory epilepsy. Although the mechanisms for SUDEP are…”
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Diaphragmatic pacing for the prevention of sudden unexpected death in epilepsy by Purnell, Benton S, Braun, Alexander, Fedele, Denise, Murugan, Madhuvika, Boison, Detlev

“…Sudden unexpected death in epilepsy is the leading cause of epilepsy related death. Currently, there are no reliable methods for preventing sudden unexpected…”
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Bispectral EEG (BSEEG) quantifying neuro-inflammation in mice induced by systemic inflammation: A potential mouse model of delirium by Yamanashi, Takehiko, Malicoat, Johnny R., Steffen, Kalvon T., Zarei, Kasra, Li, Rui, Purnell, Benton S., Najafi, Annice, Saito, Kenji, Singh, Uday, Toth, Brandon A., Lee, Shelley, Dailey, Michael E., Cui, Huxing, Kaneko, Koichi, Cho, Hyunkeun Ryan, Iwata, Masaaki, Buchanan, Gordon F., Shinozaki, Gen

“…Most of the animal studies using inflammation-induced cognitive change have relied on behavioral testing without objective and biologically solid methods to…”
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Effect of monoamine reuptake inhibition and α1 blockade on respiratory arrest and death following electroshock‐induced seizures in mice by Kruse, Stephen W., Dayton, Kyle G., Purnell, Benton S., Rosner, Jared I., Buchanan, Gordon F.

“…Summary Objective Sudden unexpected death in epilepsy (SUDEP) is the leading cause of death in patients with refractory epilepsy. Although the mechanisms for…”
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Disruption of adenosine metabolism increases risk of seizure‐induced death despite decreased seizure severity by Purnell, Benton, Bhasin, Jayant, Rust, Brian, George, Steven, Bah, Kadiatou, Lu, Tracy, Fedele, Denise, Boison, Detlev

“…Objective Respiratory arrest plays an important role in sudden unexpected death in epilepsy (SUDEP). Adenosine is of interest in SUDEP pathophysiology due to…”
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Preclinical pharmacokinetics and tolerability of a novel meglumine‐based parenteral solution of topiramate and topiramate combinations for treatment of status epilepticus by Rundfeldt, Chris, Klein, Pavel, Boison, Detlev, Rotenberg, Alexander, D'Ambrosio, Raimondo, Eastman, Cliff, Purnell, Benton, Murugan, Madhuvika, Goodkin, Howard P., Löscher, Wolfgang

“…Objective For an antiseizure medication (ASM) to be effective in status epilepticus (SE), the drug should be administered intravenously (i.v.) to provide quick…”
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Acute hydrogen sulfide-induced neurochemical and morphological changes in the brainstem by Santana Maldonado, Cristina M., Kim, Dong-Suk, Purnell, Benton, Li, Rui, Buchanan, Gordon F., Smith, Jodi, Thedens, Daniel R., Gauger, Phillip, Rumbeiha, Wilson K.

“…Hydrogen sulfide (H2S) is a toxin affecting the cardiovascular, respiratory, and central nervous systems. Acute H2S exposure is associated with a high rate of…”
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