Search Results - "Purmal, A"

The Toll-Like Receptor 5 Agonist Entolimod Mitigates Lethal Acute Radiation Syndrome in Non-Human Primates by Krivokrysenko, Vadim I, Toshkov, Ilia A, Gleiberman, Anatoli S, Krasnov, Peter, Shyshynova, Inna, Bespalov, Ivan, Maitra, Ratan K, Narizhneva, Natalya V, Singh, Vijay K, Whitnall, Mark H, Purmal, Andrei A, Shakhov, Alexander N, Gudkov, Andrei V, Feinstein, Elena

“…There are currently no approved medical radiation countermeasures (MRC) to reduce the lethality of high-dose total body ionizing irradiation expected in…”
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2403 Comparison of effect of sorafenib (SOR) and CBL0137 (CBL), a novel drug targeting facilitates chromatin transcription (FACT) complex in woodchuck model of hepatitis B-related hepatocellular carcinoma (HCC) by Priyank, P, Purmal, A, Toshkov, I, Curtin, L, Sexton, S, Iyer, R

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A deimmunized and pharmacologically optimized Toll-like receptor 5 agonist for therapeutic applications by Mett, Vadim, Kurnasov, Oleg V., Bespalov, Ivan A., Molodtsov, Ivan, Brackett, Craig M., Burdelya, Lyudmila G., Purmal, Andrei A., Gleiberman, Anatoli S., Toshkov, Ilia A., Burkhart, Catherine A., Kogan, Yakov N., Andrianova, Ekaterina L., Gudkov, Andrei V., Osterman, Andrei L.

“…The Toll-like receptor 5 (TLR5) agonist entolimod, a derivative of Salmonella flagellin, has therapeutic potential for several indications including…”
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New substrates for old enzymes. 5-Hydroxy-2'-deoxycytidine and 5-hydroxy-2'-deoxyuridine are substrates for Escherichia coli endonuclease III and formamidopyrimidine DNA N-glycosylase, while 5-hydroxy-2'-deoxyuridine is a substrate for uracil DNA N-glycosylase by ZAFER HATAHET, KOW, Y. W, PURMAL, A. A, CUNNINGHAM, R. P, WALLACE, S. S

“…5-Hydroxy-2'-deoxycytidine (5-OHdC) and 5-hydroxy-2'-deoxyuridine (5-OHdU) are major products of oxidative DNA damage with mutagenic potential. Until now, no…”
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Synthesis of Carbazole Derivative PLX01107 and its Pharmacokinetics for Various Administration Routes in CD-1 Mice by Eremina, N. V., Kazei, V. I., Purmal, A. A., Durnev, A. D.

“…The substituted carbazole drug PLX01107 is being developed for the treatment of invasive pulmonary aspergillosis. A synthetic method for PLX01107 drug…”
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422 CBL0137, a novel NFkB suppressor and p53 activator, is highly effective in pre-clinical models of neuroblastoma by Haber, M, Murray, J, Gamble, L, Carnegie-Clark, A, Webber, H, Ruhle, M, Carter, D, Oberthur, A, Fischer, M, Ziegler, D, Marshall, G.M, Gurova, K, Burkhart, C, Purmal, A, Gudkov, A.V, Norris, M.D

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Small molecule screening reveals a transcription-independent pro-survival function of androgen receptor in castration-resistant prostate cancer by Narizhneva, Natalia V., Tararova, Natalia D., Ryabokon, Petro, Shyshynova, Inna, Prokvolit, Anatoly, Komarov, Pavel G., Purmal, Andrei A., Gudkov, Andrei V., Gurova, Katerina V.

“…In prostate cancer (PCa) patients, initial responsiveness to androgen deprivation therapy is frequently followed by relapse due to development of…”
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Multiply damaged sites in DNA: Interactions with Escherichia coli endonucleases III and VIII by Harrison, Lynn, Hatahet, Zafer, Purmal, Andrei A., Wallace, Susan S.

“…Bursts of free radicals produced by ionization of water in close vicinity to DNA can produce clusters of opposed DNA lesions and these are termed multiply…”
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FACT inhibitor CBL0137, administered in an optimized schedule, potentiates radiation therapy for glioblastoma by suppressing DNA damage repair by Barone, Tara A, Robinson, Denisha L, Qiu, Jingxin, Gurova, Katerina V, Purmal, Andrei A, Gudkov, Andrei V, Plunkett, Robert J

“…Standard-of-care for glioblastoma remains surgical debulking followed by temozolomide and radiation. However, many tumors become radio-resistant while…”
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Enzymatic Processing of Uracil Glycol, a Major Oxidative Product of DNA Cytosine by Purmal, A A, Lampman, G W, Bond, J P, Hatahet, Z, Wallace, S S

“…A major stable oxidation product of DNA cytosine is uracil glycol (Ug). Because of the potential of Ug to be a strong premutagenic lesion, it is important to…”
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Antitumor effect of the curaxin CBL0137 on the models of colon cancer by Fetisov, T. I., Tilova, L. R., Lesovaya, E. A., Antoshina, E. E., Gor’kova, T. G., Trukhanova, L. S., Morozova, O. V., Shipaeva, E. V., Ivanov, R. V., Purmal, A. A., Belitskiy, G. A., Yakubovskaya, M. G., Gudkov, A. V., Gurova, K. V., Kirsanov, K. I.

“…Curaxins represent low molecular weight carbazole derivatives, which simultaneously activate p53-dependent apoptosis and inhibit NF-kBdependent signal…”
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Anticancer drug candidate CBL0137, which inhibits histone chaperone FACT, is efficacious in preclinical orthotopic models of temozolomide-responsive and -resistant glioblastoma by Barone, Tara A, Burkhart, Catherine A, Safina, Alfiya, Haderski, Gary, Gurova, Katerina V, Purmal, Andrei A, Gudkov, Andrei V, Plunkett, Robert J

“…The survival rate for patients with glioblastoma (GBM) remains dismal. New therapies targeting molecular pathways dysregulated in GBM are needed. One such…”
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Major oxidative products of cytosine, 5-hydroxycytosine and 5-hydroxyuracil, exhibit sequence context-dependent mispairing in vitro by Purmal, Andrei A., Kow, Yoke Wah, Wallace, Susan S.

“…Two major stable oxidation products of 2′-deoxy-cytidine are 2′-deoxy-5-hydroxycytldine (5-OHdC) and 2′-deoxy-5-hydroxyuridine (5-OHdU). In order to study the…”
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Pharmacological Targeting of the Histone Chaperone Complex FACT Preferentially Eliminates Glioblastoma Stem Cells and Prolongs Survival in Preclinical Models by Dermawan, Josephine Kam Tai, Hitomi, Masahiro, Silver, Daniel J, Wu, Qiulian, Sandlesh, Poorva, Sloan, Andrew E, Purmal, Andrei A, Gurova, Katerina V, Rich, Jeremy N, Lathia, Justin D, Stark, George R, Venere, Monica

“…The nearly universal recurrence of glioblastoma (GBM) is driven in part by a treatment-resistant subpopulation of GBM stem cells (GSC). To identify improved…”
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Curaxins: anticancer compounds that simultaneously suppress NF-κB and activate p53 by targeting FACT by Gasparian, Alexander V, Burkhart, Catherine A, Purmal, Andrei A, Brodsky, Leonid, Pal, Mahadeb, Saranadasa, Madhi, Bosykh, Dmitry A, Commane, Mairead, Guryanova, Olga A, Pal, Srabani, Safina, Alfiya, Sviridov, Sergey, Koman, Igor E, Veith, Jean, Komar, Anton A, Gudkov, Andrei V, Gurova, Katerina V

“…Effective eradication of cancer requires treatment directed against multiple targets. The p53 and nuclear factor κB (NF-κB) pathways are dysregulated in nearly…”
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Process for the preparation of pathogen-inactivated RBC concentrates by using PEN110 chemistry: preclinical studies by Purmal, Andrei, Valeri, C. Robert, Dzik, Walter, Pivacek, Linda, Ragno, Gina, Lazo, Aris, Chapman, John

“…BACKGROUND: A pathogen‐inactivation process for RBC concentrates is being developed by using PEN110 chemistry (INACTINE, V.I. Technologies). The objective of…”
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alpha.-Deoxyadenosine, a Major Anoxic Radiolysis Product of Adenine in DNA, Is a Substrate for Escherichia coli Endonuclease IV by Ide, Hiroshi, Tedzuka, Kei, Shimzu, Hironori, Kimura, Yoshiharu, Purmal, Andrei A, Wallace, S. S, Kow, Y. W

“…Oligonucleotides containing a unique alpha-deoxyadenosine or tetrahydrofuran (a model abasic site) were synthesized using phosphoramidite chemistry. Repair…”
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Preclinical Validation of a Single-Treatment Infusion Modality That Can Eradicate Extremity Melanomas by Kim, Minhyung, Neznanov, Nickolay, Wilfong, Chandler D, Fleyshman, Daria I, Purmal, Andrei A, Haderski, Gary, Stanhope-Baker, Patricia, Burkhart, Catherine A, Gurova, Katerina V, Gudkov, Andrei V, Skitzki, Joseph J

“…Isolated limb perfusion (ILP) with the chemotherapeutic agent melphalan is an effective treatment option for extremity in-transit melanoma but is toxic and…”
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Prevention of Colorectal Carcinogenesis by DNA-Binding Small-Molecule Curaxin CBL0137 Involves Suppression of Wnt Signaling by Kirsanov, Kirill, Fetisov, Timur, Lesovaya, Ekaterina A, Maksimova, Varvara, Trukhanova, Lubov, Antoshina, Elena, Gor'kova, Tatiana, Morozova, Olga, Safina, Alfiya, Fleyshman, Daria, Salimov, Ramiz, Shipaeva, Elena, Ivanov, Roman, Leonov, Andrey, Purmal, Andrei A, Belitsky, Gennady A, Gudkov, Andrei V, Gurova, Katerina V, Yakubovskaya, Marianna G

“…Chemoprevention is considered a valid approach to reduce the incidence of colorectal cancer, one of the most common malignancies worldwide. Here, we…”
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Inactivation of Gram-negative and Gram-positive bacteria in red cell concentrates using INACTINE PEN110 chemistry by Zavizion, B., Serebryanik, D., Chapman, J., Alford, B., Purmal, A.

“…Background and Objectives  The risk of transfusion‐transmitted bacterial infections as a result of the presence of bacteria in blood is one of the major…”
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