Search Results - "Purkis, PE"

Recessive mutation in desmoplakin disrupts desmoplakin-intermediate filament interactions and causes dilated cardiomyopathy, woolly hair and keratoderma by NORGETT, Elizabeth E, HATSELL, Sarah J, CARVAJAL-HUERTA, Luis, CABEZAS, Juan-Carlos Ruiz, COMMON, John, PURKIS, Patricia E, WHITTOCK, Neil, LEIGH, Irene M, STEVENS, Howard P, KELSELL, David P

“…Desmosomes are major cell adhesion junctions, particularly prominent in the epidermis and cardiac tissue and are important for the rigidity and strength of the…”
Get full text

Binding of Integrin alpha 6 beta 4 to Plectin Prevents Plectin Association with F-Actin but Does Not Interfere with Intermediate Filament Binding by Geerts, D, Fontao, L, Nievers, M G, Schaapveld, QJ, Purkis, P E, Wheeler, G N, Lane, E B, Leigh, I M, Sonnenberg, A

“…Hemidesmosomes are stable adhesion complexes in basal epithelial cells that provide a link between the intermediate filament network and the extra-cellular…”
Get full text

Lack of plakophilin 1 increases keratinocyte migration and reduces desmosome stability by South, Andrew P, Wan, Hong, Stone, Michael G, Dopping-Hepenstal, Patricia J C, Purkis, Patricia E, Marshall, John F, Leigh, Irene M, Eady, Robin A J, Hart, Ian R, McGrath, John A

“…Ablation of the desmosomal plaque component plakophilin 1 underlies the autosomal recessive genodermatosis, skin fragility-ectodermal dysplasia syndrome (OMIM…”
Get full text

Haploinsufficiency of Desmoplakin Causes a Striate Subtype of Palmoplantar Keratoderma by Armstrong, D. Keith B., McKenna, Kevin E., Purkis, Patricia E., Green, Kathleen J., Eady, Robin A. J., Leigh, Irene M., Hughes, Anne E.

“…Desmosomes are highly organized intercellular adhesive junctions that are particularly prominent in epidermis and other tissues experiencing mechanical stress…”
Get full text

Basal cell glycoprotein in pig epidermis closely resembles the beta 1 subunit of the integrin family of cell adhesion molecules by King, I A, Tabiowo, A, Fryer, P R, Purkis, P E, Leigh, I

“…A 135-kD conA-binding glycoprotein isolated from pig epidermis was previously localized to the surface of basal cells in stratified epithelia using…”
Get full text

Keratins (K16 and K17) as markers of keratinocyte hyperproliferation in psoriasis in vivo and in vitro by Leigh, I M, Navsaria, H, Purkis, P E, McKay, I A, Bowden, P E, Riddle, P N

“…Keratinocyte differentiation in psoriasis was examined using a panel of monospecific monoclonal antibodies to keratins (K), including two recently developed…”
Get more information

Striate palmoplantar keratoderma arising from desmoplakin and desmoglein 1 mutations is associated with contrasting perturbations of desmosomes and the keratin filament network by Wan, H., Dopping-Hepenstal, P.J.C., Gratian, M.J., Stone, M.G., Zhu, G., Purkis, P.E., South, A.P., Keane, F., Armstrong, D.K.B., Buxton, R.S., McGrath, J.A., Eady, R.A.J.

“…Summary Background  Several hereditary human diseases are now known to be caused by distinct mutations in genes encoding various desmosome components. Although…”
Get full text

Antibody markers of basal cells in complex epithelia by PURKIS, P. E, STEEL, J. B, MACKENZIE, I. C, NATHRATH, W. B. J, LEIGH, I. M, LANE, E. B

“…In the course of immunohistochemical studies it has become apparent that there is a distinct phenotype of keratin expression that is shared by basal epithelial…”
Get full text

Keratin 19: Predicted Amino Acid Sequence and Broad Tissue Distribution Suggest it Evolved from Keratinocyte Keratins by Stasiak, Pauline C., Purkis, Patricia E., Leigh, Irene M., Lane, E. Birgitte

“…Abstract only…”
Get full text

Keratin antigens in differentiating skin by Lane, E B, Bártek, J, Purkis, P E, Leigh, I M

Get more information

Monospecific monoclonal antibodies to keratin 1 carboxy terminal (synthetic peptide) and to keratin 10 as markers of epidermal differentiation by Leigh, I M, Purkis, P E, Whitehead, P, Lane, E B

“…Monospecific antibodies to individual keratin polypeptides can be used to examine the tissue and cellular coexpression of members of keratin pairs…”
Get more information

Treatment of chronic venous ulcers with sheets of cultured allogenic keratinocytes by Leigh, I M, Purkis, P E, Navsaria, H A, Phillips, T J

“…Cultured keratinocytes were used as allografts to treat 51 patients with chronic venous ulceration or rheumatoid ulcers unresponsive to all previous…”
Get more information

Keratin 17 expression as a marker for epithelial transformation in viral warts by Proby, CM, Churchill, L, Purkis, PE, Glover, MT, Sexton, CJ, Leigh, IM

“…The profile of keratin expression in benign warts from various cutaneous and mucosal sites along with dysplastic warts and squamous cell carcinomas has been…”
Get full text

Fine genetic mapping of diffuse non-epidermolytic palmoplantar keratoderma to chromosome 12q11-q13: exclusion of the mapped type II keratins by Kelsell, D. P., Stevens, H. P., Purkis, P. E., Talas, U., Rustin, M. H. A., Leigh, I. M.

“…: Diffuse non‐epidermolytic palmoplantar keratoderma (NEPPK) belongs to the heterogeneous group of skin diseases characterized by thickening of the stratum…”
Get full text

Type VII Collagen is a Normal Component of Epidermal Basement Membrane, Which Shows Altered Expression in Recessive Dystrophic Epidermolysis Bullosa by Leigh, Irene M., Eady, Robin A.J., Heagerty, Adrian H.M., Purkis, Patricia E., Whitehead, Philip A., Burgeson, Robert E.

“…The murine monoclonal antibody LH 7:2, which reacts with the basement membrane of stratified squamous epithelia including epidermis, has been characterized…”
Get full text

Epidermal differentiation and dermal changes in healing following treatment of surgical wounds with sheets of cultured allogeneic keratinocytes by Myers, S R, Navsaria, H A, Brain, A N, Purkis, P E, Leigh, I M

“…AIMS--To establish the structural changes that occur in deep surgical wounds engrafted with allogeneic sheets, their time course and inter-relation…”
Get full text

Expression of beta human chorionic gonadotrophin by non-trophoblastic non-endocrine 'normal' and malignant epithelial cells by ILES, R. K, PURKIS, P. E, WHITEHEAD, P. C, OLIVER, R. T. D, LEIGH, I, CHARD, T

“…Expression of hCG and its free subunits by non-trophoblastic tumours is well recognised. Previously we reported hCG secretion by normal and malignant bladder…”
Get full text

Morphological changes of neural and vascular peptides in human skin suction blister injury by Gu, X H, Terenghi, G, Purkis, P E, Price, D A, Leigh, I M, Polak, J M

“…Suction blister injury is an experimental model for the investigation of the possible derangement of dermal/epidermal interaction in injury. An extensive fibre…”
Get more information

Culture grafted leg ulcers by Leigh, I M, Purkis, P E

Get more information

The distribution of LH39 basement membrane epitope in the tumour stroma of oral squamous cell carcinomas by Almeida, B M, Challacombe, S J, Eveson, J W, Morgan, P R, Purkis, P E, Leigh, I M

“…LH39 monoclonal antibody detects a novel component of epithelial and endothelial basement membranes. The expression of LH39 antigen was investigated by…”
Get more information