Search Results - "Purington, Lauren C."

Gi/o-coupled receptors compete for signaling to adenylyl cyclase in SH-SY5Y cells and reduce opioid-mediated cAMP overshoot by Levitt, Erica S, Purington, Lauren C, Traynor, John R

“…Organization of G protein-coupled receptors and cognate signaling partners at the plasma membrane has been proposed to occur via multiple mechanisms, including…”
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Fumaroylamino-4,5-epoxymorphinans and Related Opioids with Irreversible μ Opioid Receptor Antagonist Effects by Moynihan, Humphrey A, Derrick, Ian, Broadbear, Jillian H, Greedy, Benjamin M, Aceto, Mario D, Harris, Louis S, Purington, Lauren C. S, Thomas, Mark P, Woods, James H, Traynor, John R, Husbands, Stephen M, Lewis, John W

“…We have previously shown that cinnamoyl derivatives of 14β-amino-17-cyclopropylmethyl-7,8-dihydronormorphinone and 7α-aminomethyl-6,14-endoethanonororipavine…”
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Development and in Vitro Characterization of a Novel Bifunctional μ-Agonist/δ-Antagonist Opioid Tetrapeptide by Purington, Lauren C, Sobczyk-Kojiro, Katarzyna, Pogozheva, Irina D, Traynor, John R, Mosberg, Henry I

“…The development of tolerance to and dependence on opioid analgesics greatly reduces their long-term usefulness. Previous studies have demonstrated that…”
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Pentapeptides Displaying μ Opioid Receptor Agonist and δ Opioid Receptor Partial Agonist/Antagonist Properties by Purington, Lauren C, Pogozheva, Irina D, Traynor, John R, Mosberg, Henry I

“…Chronic use of μ-opioid agonists has been shown to cause neurochemical adaptations resulting in tolerance and dependence. While the analgesic effects of these…”
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Modulation of Opioid Receptor Ligand Affinity and Efficacy Using Active and Inactive State Receptor Models by Anand, Jessica P., Purington, Lauren C., Pogozheva, Irina D., Traynor, John R., Mosberg, Henry I.

“…Mu opioid receptor (MOR) agonists are widely used for the treatment of pain; however, chronic use results in the development of tolerance and dependence. It…”
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Mixed κ/μ Opioid Receptor Agonists: The 6β-Naltrexamines by Cami-Kobeci, Gerta, Neal, Adrian P, Bradbury, Faye A, Purington, Lauren C, Aceto, Mario D, Harris, Louis S, Lewis, John W, Traynor, John R, Husbands, Stephen M

“…Ligands from the naltrexamine series have consistently demonstrated agonist activity at κ opioid receptors (KOR), with varying activity at the μ opioid…”
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Mixed K/μ Opioid Receptor Agonists : The 6β-Naltrexamines by CAMI-KOBECI, Gerta, NEAL, Adrian P, BRADBURY, Faye A, PURINGTON, Lauren C, ACETO, Mario D, HARRIS, Louis S, LEWIS, John W, TRAYNOR, John R, HUSBANDS, Stephen M

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Investigating interactions between mu and delta opioid receptors using bifunctional peptides by Purington, Lauren C. S

“…Morphine and other opioids exert their effects by activation of opioid receptors, which belong to the G protein-coupled receptor (GPCR) superfamily. Clinically…”
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Investigating interactions between mu and delta opioid receptors using bifunctional peptides by Purington, Lauren C. S

“…Morphine and other opioids exert their effects by activation of opioid receptors, which belong to the G protein-coupled receptor (GPCR) superfamily. Clinically…”
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