Search Results - "Purdy, Robert H."

Pharmacokinetic and behavioral effects of allopregnanolone in healthy women by Timby, Erika, Balgård, Matts, Nyberg, Sigrid, Spigset, Olav, Andersson, Agneta, Porankiewicz-Asplund, Joanna, Purdy, Robert H, Zhu, Di, Bäckström, Torbjörn, Poromaa, Inger Sundström

“…The behavioral effects of allopregnanolone (3alpha-hydroxy-5alpha-pregnan-20-one) in women are not known. Allopregnanolone, a neuroactive steroid secreted by…”
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Steroid pregnenolone sulfate enhances NMDA-receptor-independent long-term potentiation at hippocampal CA1 synapses: Role for L-type calcium channels and sigma-receptors by Sabeti, Jilla, Nelson, Thomas E., Purdy, Robert H., Gruol, Donna L.

“…Severe stress elevates plasma and CNS levels of endogenous neuroactive steroids that can contribute to the influence of stress on memory formation. Among the…”
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Administration of progesterone produces mild sedative-like effects in men and women by Söderpalm, Anna H.V, Lindsey, Sommer, Purdy, Robert H, Hauger, Richard, de Wit, Harriet

“…The goal of this study was to investigate the behavioral and subjective effects of a single dose of progesterone in men and women. Certain metabolites of…”
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Neuroactive steroid stereospecificity of ethanol-like discriminative stimulus effects in monkeys by Grant, Kathleen A, Helms, Christa M, Rogers, Laura S M, Purdy, Robert H

“…Positive modulation of GABA(A) and antagonism of N-methyl-D-aspartate receptors mediate the discriminative stimulus effects of ethanol. Endogenous neuroactive…”
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Ethanol-induced increases in neuroactive steroids in the rat brain and plasma are absent in adrenalectomized and gonadectomized rats by O'Dell, Laura E., Alomary, Ahmed A., Vallée, Monique, Koob, George F., Fitzgerald, Robert L., Purdy, Robert H.

“…Peripheral administration of alcohol has been demonstrated to cause significant increases in neurosteroid levels in the brain and periphery. These findings…”
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Ethanol markedly increases “GABAergic” neurosteroids in alcohol-preferring rats by Barbaccia, Maria Luisa, Affricano, Daniela, Trabucchi, Marco, Purdy, Robert H, Colombo, Giancarlo, Agabio, Roberta, Gessa, Gian Luigi

“…Alcohol administration (1 g/kg, i.p.) increased the levels of the neurosteroids 3α-hydroxy-5α-pregnan-20-one (allopregnanolone) and…”
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Nicotine-induced changes in cerebrocortical neuroactive steroids and plasma corticosterone concentrations in the rat by Porcu, Patrizia, Sogliano, Cristiana, Cinus, Monica, Purdy, Robert H, Biggio, Giovanni, Concas, Alessandra

“…Nicotine, one of the most widely used psychotropic substances, is able to induce both anxiolytic and anxiogenic effects. The effect of this drug on the brain…”
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Brain Steroidogenesis Mediates Ethanol Modulation of GABAA Receptor Activity in Rat Hippocampus by Sanna, Enrico, Talani, Giuseppe, Busonero, Fabio, Pisu, Maria Giuseppina, Purdy, Robert H, Serra, Mariangela, Biggio, Giovanni

“…An interaction with the GABA type A (GABA(A)) receptor has long been recognized as one of the main neurochemical mechanisms underlying many of the…”
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Characterization of the discriminative stimulus effects of the neuroactive steroid pregnanolone in DBA/2J and C57BL/6J inbred mice by Shannon, Erin E, Porcu, Patrizia, Purdy, Robert H, Grant, Kathleen A

“…Neurosteroids represent a class of endogenous compounds that exert rapid, nongenomic effects through neurotransmitter receptor systems such as GABA(A). Two…”
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Progesterone enhances ethanol‐induced modulation of mesocortical dopamine neurons: antagonism by finasteride by Dazzi, Laura, Serra, Mariangela, Seu, Emanuele, Cherchi, Giulia, Pisu, M. Giuseppina, Purdy, Robert H., Biggio, Giovanni

“…The effect of endogenous 3α‐hydroxy‐5α‐pregnan‐20‐one (3α,5α‐TH PROG) on the modulation of mesocortical dopamine extracellular concentration by ethanol was…”
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Acutely Administered Ethanol Participates in Testosterone Synthesis and Increases Testosterone in Rat Brain by Alomary, Ahmed A., Vallée, Monique, O'Dell, Laura E., Koob, George F., Purdy, Robert H., Fitzgerald, Robert L.

“…Background: The interaction of alcohol and testosterone has long been of interest, mainly due to the effect of alcohol on aggression and sexual behavior. To…”
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Neuroactive Steroids and Ethanol by Purdy, Robert H., Valenzuela, C Fernando, Janak, Patricia H., Finn, Deborah A., Biggio, Giovanni, Bäckström, Torbjörn

“…This article presents the proceedings of a symposium presented at the International Society for Biomedical Research on Alcoholism 12th World Congress on…”
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Neuroactive steroids: new biomarkers of cognitive aging by Vallée, Monique, Purdy, Robert H, Mayo, Willy, Koob, George F, Le Moal, Michel

“…Intensive studies in animals established that neuroactive steroids display neuronal actions and influence behavioral functions. We describe here investigations…”
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Role of allopregnanolone in regulation of GABAA receptor plasticity during long-term exposure to and withdrawal from progesterone by FOLLESA, Paolo, CONCAS, Alessandra, PORCU, Patrizia, SANNA, Enrico, SERRA, Mariangela, MOSTALLINO, Maria Cristina, PURDY, Robert H, BIGGIO, Giovanni

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Social isolation-induced decreases in both the abundance of neuroactive steroids and GABA(A) receptor function in rat brain by Serra, M, Pisu, M G, Littera, M, Papi, G, Sanna, E, Tuveri, F, Usala, L, Purdy, R H, Biggio, G

“…The effects of social isolation on behavior, neuroactive steroid concentrations, and GABA(A) receptor function were investigated in rats. Animals isolated for…”
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Stress and neuroactive steroids by Barbaccia, M L, Serra, M, Purdy, R H, Biggio, G

“…The discovery that the endogenous steroid derivatives 3 alpha-hydroxy-5 alpha-pregnan-20-one (allopregnanolone, or 3 alpha,5 alpha-TH PROG) and 3…”
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Neurosteroid secretion in panic disorder by Brambilla, Francesca, Biggio, Giovanni, Pisu, Maria Giuseppina, Bellodi, Laura, Perna, Giampaolo, Bogdanovich-Djukic, Vesna, Purdy, Robert H., Serra, Mariangela

“…Evidence that neurosteroids have anxiolytic effects in animal models of anxiety has suggested that alterations of neurosteroid secretion might be implicated in…”
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Clozapine, but not Haloperidol, Increases Brain Concentrations of Neuroactive Steroids in the Rat by Barbaccia, Maria Luisa, Affricano, Daniela, Purdy, Robert H, Maciocco, Elisabetta, Spiga, Francesca, Biggio, Giovanni

“…The extrapyramidal side effects of typical antipsychotics, which are induced to a markedly reduced extent by clozapine, have been linked to a dysfunction of…”
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Quantification of Neurosteroids in Rat Plasma and Brain Following Swim Stress and Allopregnanolone Administration Using Negative Chemical Ionization Gas Chromatography/Mass Spectrometry by Vallée, Monique, Rivera, Jeffery D., Koob, George F., Purdy, Robert H., Fitzgerald, Robert L.

“…A simplified method for the quantitative analysis of neurosteroids in rat plasma and brain is described. The method uses negative chemical ionization gas…”
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Progesterone, 5 α-pregnane-3,20-dione and 3 α-hydroxy-5 α-pregnane-20-one in specific regions of the human female brain in different endocrine states by Bixo, Marie, Andersson, Agneta, Winblad, Bengt, Purdy, Robert H, Bäckström, Torbjörn

“…Post-mortem concentrations of progesterone, 5 α-pregnane-3,20-dione (5 α-DHP) and 3 α-hydroxy-5 α-pregnane-20-one (allopregnanolone) were measured in 17 brain…”
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