Search Results - "Purcell, Daniel J"
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A Distinct Mechanism for Coactivator versus Corepressor Function by Histone Methyltransferase G9a in Transcriptional Regulation
Published in The Journal of biological chemistry (09-12-2011)“…Histone methyltransferase G9a has been understood primarily as a corepressor of gene expression, but we showed previously that G9a positively regulates nuclear…”
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Runx2 transcriptome of prostate cancer cells: insights into invasiveness and bone metastasis
Published in Molecular cancer (23-09-2010)“…Prostate cancer (PCa) cells preferentially metastasize to bone at least in part by acquiring osteomimetic properties. Runx2, an osteoblast master transcription…”
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Recruitment of coregulator G9a by Runx2 for selective enhancement or suppression of transcription
Published in Journal of cellular biochemistry (01-07-2012)“…Runx2, best known for its role in regulating osteoblast‐specific gene expression, also plays an increasingly recognized role in prostate and breast cancer…”
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Clonal Isolation of Different Strains of Mouse Mammary Tumor Virus-Like DNA Sequences from Both the Breast Tumors and Non-Hodgkin’s Lymphomas of Individual Patients Diagnosed with Both Malignancies
Published in Clinical cancer research (01-09-2004)“…Purpose: In a previous study, we had detected the presence of mouse mammary tumor virus (MMTV)-like envelope (ENV) gene sequences in both the breast tumors and…”
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Gene-Specific Patterns of Coregulator Requirements by Estrogen Receptor-α in Breast Cancer Cells
Published in Molecular endocrinology (Baltimore, Md.) (01-06-2012)“…Progesterone receptor (PgR) controls the menstrual cycle, pregnancy, embryonic development, and homeostasis, and it plays important roles in breast cancer…”
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Modulation of Runx2 Activity by Estrogen Receptor-α: Implications for Osteoporosis and Breast Cancer
Published in Endocrinology (Philadelphia) (01-12-2008)“…The transcription factors Runx2 and estrogen receptor-α (ERα) are involved in numerous normal and disease processes, including postmenopausal osteoporosis and…”
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Novel CARM1-Interacting Protein, DZIP3, Is a Transcriptional Coactivator of Estrogen Receptor-α
Published in Molecular endocrinology (Baltimore, Md.) (01-12-2015)“…Coactivator-associated arginine methyltransferase 1 (CARM1) is known to promote estrogen receptor (ER)α-mediated transcription in breast cancer cells. To…”
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Abstract 1235: Quantitative high-content imaging reveals novel modulators of the metastatic hybrid state during epithelial-mesenchymal transition
Published in Cancer research (Chicago, Ill.) (04-04-2023)“…Epithelial-mesenchymal transition (EMT) is a normal developmental and healing process that can be pathologically reactivated during cancer progression. Through…”
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Modulation of Runx2 Activity by Estrogen Receptor-a : Implications for Osteoporosis and Breast Cancer
Published in Endocrinology (Philadelphia) (2008)Get full text
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