Search Results - "Purcell, Damian F. J."
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Reprogrammed CRISPR-Cas13b suppresses SARS-CoV-2 replication and circumvents its mutational escape through mismatch tolerance
Published in Nature communications (13-07-2021)“…The recent dramatic appearance of variants of concern of SARS-coronavirus-2 (SARS-CoV-2) highlights the need for innovative approaches that simultaneously…”
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High level of genomic divergence in orf-I p12 and hbz genes of HTLV-1 subtype-C in Central Australia
Published in Retrovirology (17-07-2024)“…Human T cell lymphotropic virus type 1 (HTLV-1) infection remains a largely neglected public health problem, particularly in resource-poor areas with high…”
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Current State of Therapeutics for HTLV-1
Published in Viruses (15-10-2024)“…Human T cell leukaemia virus type-1 (HTLV-1) is an oncogenic retrovirus that causes lifelong infection in ~5-10 million individuals globally. It is endemic to…”
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Enhancement of Antibody-Dependent Cellular Cytotoxicity and Phagocytosis in Anti-HIV-1 Human-Bovine Chimeric Broadly Neutralizing Antibodies
Published in Journal of virology (10-06-2021)“…No prophylactic vaccine has provided robust protection against human immunodeficiency virus type 1 (HIV-1). Vaccine-induced broadly neutralizing antibodies…”
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Role of HTLV-1 orf-I encoded proteins in viral transmission and persistence
Published in Retrovirology (18-12-2019)“…The human T cell leukemia virus type 1 (HTVL-1), first reported in 1980 by Robert Gallo's group, is the etiologic agent of both cancer and inflammatory…”
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p30 protein: a critical regulator of HTLV-1 viral latency and host immunity
Published in Retrovirology (18-12-2019)“…The extraordinarily high prevalence of HTLV-1 subtype C (HTLV-1C) in some isolated indigenous communities in Oceania and the severity of the health conditions…”
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HIV latency reversing agents act through Tat post translational modifications
Published in Retrovirology (11-05-2018)“…Different classes of latency reversing agents (LRAs) are being evaluated to measure their effects in reactivating HIV replication from latently infected cells…”
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Functional properties and sequence variation of HTLV-1 p13
Published in Retrovirology (12-05-2020)“…Human T cell leukemia virus type-1 (HTLV-1) was the first retrovirus found to cause cancer in humans, but the mechanisms that drive the development of leukemia…”
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Heparin Inhibits SARS-CoV-2 Replication in Human Nasal Epithelial Cells
Published in Viruses (24-11-2022)“…SARS-CoV-2 is the causative agent of the COVID-19 pandemic. Vaccination, supported by social and public health measures, has proven efficacious for reducing…”
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Hyperimmune Bovine Colostrum as a Low-Cost, Large-Scale Source of Antibodies with Broad Neutralizing Activity for HIV-1 Envelope with Potential Use in Microbicides
Published in Antimicrobial Agents and Chemotherapy (01-08-2012)“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Conjugation of an scFab domain to the oligomeric HIV envelope protein for use in immune targeting
Published in PloS one (20-08-2019)“…A promising strategy for the enhancement of vaccine-mediated immune responses is by directly targeting protein antigens to immune cells. Targeting of antigens…”
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Suppression subtractive hybridization method for the identification of a new strain of murine hepatitis virus from xenografted SCID mice
Published in Archives of virology (01-12-2015)“…During attempts to clone retroviral determinants associated with a mouse model of Langerhans cell histiocytosis (LCH), suppression subtractive hybridization…”
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Tissue-Specific Sequence Alterations in the Human Immunodeficiency Virus Type 1 Envelope Favoring CCR5 Usage Contribute to Persistence of Dual-Tropic Virus in the Brain
Published in Journal of Virology (01-06-2009)“…Erratum ( vol. 83 , p. 7794 ) Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious…”
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Repeated Vaccination of Cows with HIV Env gp140 during Subsequent Pregnancies Elicits and Sustains an Enduring Strong Env-Binding and Neutralising Antibody Response
Published in PloS one (01-06-2016)“…An important feature of a potential vaccine against HIV is the production of broadly neutralising antibodies (BrNAbs) capable of potentially blocking…”
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SARS-CoV-2 suppresses IFNβ production mediated by NSP1, 5, 6, 15, ORF6 and ORF7b but does not suppress the effects of added interferon
Published in PLoS pathogens (01-08-2021)“…Type I Interferons (IFN-Is) are a family of cytokines which play a major role in inhibiting viral infection. Resultantly, many viruses have evolved mechanisms…”
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Liquid Chalk Is an Antiseptic against SARS-CoV-2 and Influenza A Respiratory Viruses
Published in mSphere (16-06-2021)“…The COVID-19 pandemic has impacted and enforced significant restrictions within our societies, including the attendance of public and professional athletes in…”
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Use of laser capture microdissection to detect integrated HIV-1 DNA in macrophages and astrocytes from autopsy brain tissues
Published in Journal of neurovirology (01-04-2006)“…The importance of astrocytes as a reservoir of human immunodeficiency virus type 1 (HIV-1) in the brain remains elusive. By combining immunohistochemistry,…”
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Small Interfering RNAs against the TAR RNA Binding Protein, TRBP, a Dicer Cofactor, Inhibit Human Immunodeficiency Virus Type 1 Long Terminal Repeat Expression and Viral Production
Published in Journal of Virology (01-05-2007)“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Low TRBP Levels Support an Innate Human Immunodeficiency Virus Type 1 Resistance in Astrocytes by Enhancing the PKR Antiviral Response
Published in Journal of Virology (01-10-2005)“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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