Search Results - "Puranik, Mrinalini"

Hypoxanthine guanine phosphoribosyltransferase distorts the purine ring of nucleotide substrates and perturbs the pKa of bound xanthosine monophosphate by Gogia, Spriha, Balaram, Hemalatha, Puranik, Mrinalini

“…Enzymatic efficiency and structural discrimination of substrates from nonsubstrate analogues are attributed to the precise assembly of binding pockets. Many…”
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Initial Excited State Dynamics of Lumichrome upon Ultraviolet Excitation by Ghosh, Sudeb, Puranik, Mrinalini

“…Lumichrome (LC) is the major photodegradation product of biologically important flavin cofactors. Since LC serves as a structural comparison with the flavins;…”
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Mechanism of Discrimination of 8‑Oxoguanosine versus Guanosine by Escherichia coli Fpg by Jayanth, Namrata, Puranik, Mrinalini

“…The mutagenic 8-oxoguanosine monophosphate, the predominant product of DNA oxidation, is excised by formamidopyrimidine glycosylase (Fpg) in bacteria. The…”
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Deep ultraviolet initiated excited state dynamics of riboflavin and flavin mononucleotide by Ghosh, Sudeb, Puranik, Mrinalini

“…Flavins are cofactors in several light‐activated enzymes and therefore their excited states are found to involve in many photobiological processes. Excited…”
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Ultrafast Nuclear Dynamics of Photoexcited Guanosine-5′-Monophosphate in Three Singlet States by Mondal, Sayan, Puranik, Mrinalini

“…We report measurement of resonance Raman (RR) spectra of guanosine-5′-monophosphate (GMP), a DNA nucleotide at excitation wavelengths throughout its ππ*…”
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Initial excited state structural dynamics of lumiflavin upon ultraviolet excitation by Ghosh, Sudeb, Puranik, Mrinalini

“…[Display omitted] •Ultrafast structural dynamics of lumiflavin was determined using resonance Raman intensity analysis upon UV excitation.•Excited state…”
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Dynamics of Carbon Monoxide Binding to CooA by Puranik, Mrinalini, Nielsen, Steen Brøndsted, Youn, Hwan, Hvitved, Angela N, Bourassa, James L, Case, Martin A, Tengroth, Charbel, Balakrishnan, Gurusamy, Thorsteinsson, Marc V, Groves, John T, McLendon, George L, Roberts, Gary P, Olson, John S, Spiro, Thomas G

“…CooA is a dimeric CO-sensing heme protein from Rhodospirillum rubrum. The heme iron in reduced CooA is six-coordinate; the axial ligands are His-77 and Pro-2…”
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Sub-50 fs excited state dynamics of 6-chloroguanine upon deep ultraviolet excitation by Mondal, Sayan, Puranik, Mrinalini

“…The photophysical properties of natural nucleobases and their respective nucleotides are ascribed to the sub-picosecond lifetime of their first singlet states…”
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Kinetics of Melanin Polymerization during Enzymatic and Nonenzymatic Oxidation by Mondal, Sayan, Thampi, Arya, Puranik, Mrinalini

“…Melanin is an abundant biopigment in the animal kingdom, but its structure remains poorly understood. This is a substantial impediment to understanding the…”
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Heme Displacement Mechanism of CooA Activation by Ibrahim, Mohammed, Kerby, Robert L., Puranik, Mrinalini, Wasbotten, Ingar H., Youn, Hwan, Roberts, Gary P., Spiro, Thomas G.

“…The heme-containing protein CooA of Rhodospirillum rubrum regulates the expression of genes involved in CO oxidation. CooA binds its target DNA sequence in…”
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Excited State Structure and Dynamics of p-Benzoquinone and Bromanil from Time-Resolved Resonance Raman Spectra and Simulation by Puranik, Mrinalini, Umapathy, Siva

“…p-Benzoquinone and its halogen substituted derivatives are known to have differing reactivities in the triplet excited state. While bromanil catalyzes the…”
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Developing a Coarse-Grained Model for Bacterial Cell Walls: Evaluating Mechanical Properties and Free Energy Barriers by Vaiwala, Rakesh, Sharma, Pradyumn, Puranik, Mrinalini, Ayappa, K. Ganapathy

“…The bacterial cell envelope of Gram-negative bacteria is a complex biological barrier with multiple layers consisting of the inner membrane, periplasm of…”
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Solution structure of ligands involved in purine salvage pathway by Karnawat, Vishakha, Puranik, Mrinalini

“…[Display omitted] •UVRR spectra of purines involved in the purine salvage pathway are reported.•Structural parameters and vibrational spectra are determined…”
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Vibrational markers of structural distortion in adenine nucleobases upon DNA damage by Shanmugasundaram, Marudachalam, Puranik, Mrinalini

“…Oxidation is one of the common causes of chemical damage of DNA. Among the oxidized nucleobases in DNA, 8-oxoadenine (8-oxoA) and…”
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Time-Resolved Resonance Raman and Density Functional Studies on the Ground State and Short-Lived Intermediates of Tetrabromo-p-benzoquinone by Puranik, Mrinalini, Chandrasekhar, Jayaraman, Snijders, Jaap G, Umapathy, Siva

“…Time-resolved resonance Raman (TR3) and density functional theoretical (DFT) studies on the photogenerated transient intermediates of tetrabromo-p-benzoquinone…”
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Structure of the triplet excited state of tetrabromo- p-benzoquinone from time-resolved resonance Raman spectra and ab initio calculations by Puranik, Mrinalini, Chandrasekhar, Jayaraman, Umapathy, Siva

“…The triplet excited state of bromanil has been observed using time-resolved resonance Raman spectroscopy. Assignments of the bands have been made by comparison…”
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Solution structures of purine base analogues 9-deazaguanine and 9-deazahypoxanthine by Karnawat, Vishakha, Puranik, Mrinalini

“…Deaza analogues of nucleobases are potential drugs against infectious diseases caused by parasites. A caveat is that apart from binding their target parasite…”
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Assessing Barriers for Antimicrobial Penetration in Complex Asymmetric Bacterial Membranes: A Case Study with Thymol by Sharma, Pradyumn, Parthasarathi, Srividhya, Patil, Nivedita, Waskar, Morris, Raut, Janhavi S, Puranik, Mrinalini, Ayappa, K. Ganapathy, Basu, Jaydeep Kumar

“…The bacterial cell envelope is a complex multilayered structure evolved to protect bacteria in hostile environments. An understanding of the molecular basis…”
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Computational prediction of vibrational spectra of normal and modified DNA nucleobases by Shanmugasundaram, Marudachalam, Puranik, Mrinalini

“…Purines, pyrimidines, and the corresponding ribose monophosphates are ubiquitous biomolecules involved in several cellular processes–in DNA and RNA, signaling,…”
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Methylation Stabilizes the Imino Tautomer of dAMP and Amino Tautomer of dCMP in Solution by Jayanth, Namrata, Puranik, Mrinalini

“…Alkylating agents cause methylation of adenosine and cytidine in DNA to generate 1-methyladenosine and 3-methylcytidine. These modified nucleosides can serve…”
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