Search Results - "Pupyshev, Alexander B."

Disaccharide trehalose in experimental therapies for neurodegenerative disorders: Molecular targets and translational potential by Pupyshev, Alexander B., Klyushnik, Tatyana P., Akopyan, Anna A., Singh, Sandeep Kumar, Tikhonova, Maria A.

“…Induction of autophagy is a prospective approach to the treatment of neurodegeneration. In the recent decade, trehalose attracted special attention. It is an…”
Get full text

Alimentary Treatment with Trehalose in a Pharmacological Model of Alzheimer's Disease in Mice: Effects of Different Dosages and Treatment Regimens by Pupyshev, Alexander B, Akopyan, Anna A, Tenditnik, Michael V, Ovsyukova, Marina V, Dubrovina, Nina I, Belichenko, Victor M, Korolenko, Tatiana A, Zozulya, Svetlana A, Klyushnik, Tatiana P, Tikhonova, Maria A

“…In the treatment of experimental neurodegeneration with disaccharide trehalose, various regimens are used, predominantly a 2% solution, drunk for several…”
Get full text

Treatment with Autophagy Inducer Trehalose Alleviates Memory and Behavioral Impairments and Neuroinflammatory Brain Processes in db/db Mice by Korolenko, Tatiana A, Dubrovina, Nina I, Ovsyukova, Marina V, Bgatova, Nataliya P, Tenditnik, Michael V, Pupyshev, Alexander B, Akopyan, Anna A, Goncharova, Natalya V, Lin, Chih-Li, Zavjalov, Evgeny L, Tikhonova, Maria A, Amstislavskaya, Tamara G

“…Autophagy attenuation has been found in neurodegenerative diseases, aging, diabetes mellitus, and atherosclerosis. In experimental models of neurodegenerative…”
Get full text

Therapeutic activation of autophagy by combined treatment with rapamycin and trehalose in a mouse MPTP-induced model of Parkinson's disease by Pupyshev, Alexander B., Tikhonova, Maria A., Akopyan, Anna A., Tenditnik, Michael V., Dubrovina, Nina I., Korolenko, Tatyana A.

“…The neuroprotective effect of autophagy activation by rapamycin and trehalose was studied in a mouse model of Parkinson's disease (PD) induced by neurotoxin…”
Get full text

Comparative analysis of early neurodegeneration signs in a mouse model of Alzheimer’s disease-like pathology induced by two types of the central (Intracerebroventricular vs. Intrahippocampal) administration of Aβ25–35 oligomers by Belichenko, Victor M., Bashirzade, Alim A., Tenditnik, Michael V., Dubrovina, Nina I., Akopyan, Anna A., Ovsyukova, Marina V., Fedoseeva, Larisa A., Pupyshev, Alexander B., Aftanas, Lyubomir I., Amstislavskaya, Tamara G., Tikhonova, Maria A.

“…Animal models of Alzheimer’s disease (AD) induced by intracerebroventricular (ICV) or intrahippocampal (IH) administration of amyloid-beta (Aβ) are widely used…”
Get full text

Combined induction of mTOR-dependent and mTOR-independent pathways of autophagy activation as an experimental therapy for Alzheimer's disease-like pathology in a mouse model by Pupyshev, Alexander B., Belichenko, Victor M., Tenditnik, Michael V., Bashirzade, Alim A., Dubrovina, Nina I., Ovsyukova, Marina V., Akopyan, Anna A., Fedoseeva, Larisa A., Korolenko, Tatiana A., Amstislavskaya, Tamara G., Tikhonova, Maria A.

“…Alzheimer's disease (AD) is associated with amyloid-β (Aβ) accumulation that might be hindered by autophagy. There are two ways to induce autophagy: through…”
Get full text

Suppression of autophagy in the brain of transgenic mice with overexpression of А53Т-mutant α-synuclein as an early event at synucleinopathy progression by Pupyshev, Alexander B., Korolenko, Tatiana A., Akopyan, Anna A., Amstislavskaya, Tamara G., Tikhonova, Maria A.

“…•Mutant α-synuclein overexpression in mice induces autophagy suppression in the brain.•The autophagy suppression is stronger in the striatum than in…”
Get full text

Diabetes Type 2 as a Risk Factor of Neurodegeneration Development and Cognitive Impairment in db/db Mice by Korolenko, Tatyana A., Dubrovina, Nina I., Ovsyukova, Marina V., Bgatova, Natalya, Pupyshev, Alexander B., Anufrienko, Elena V., Lin, Chih-Li, Zavjalov, Evgeniy L.

“…Diabetes T2 with insulin resistance is a serious disease all over the world with a tendency to steady increase the number of cases and a risk factor of…”
Get full text