Search Results - "Pupyshev, A B"

Effect of Trehalose Disaccharide on Activation of Microglia and Indices of Systemic Inflammation in an Experimental Model of Alzheimer’s Disease by Zozulya, S. A., Akopyan, A. A., Tenditnik, M. V., Ovsyukova, M. V., Korolenko, T. A., Klyushnik, T. P., Tikhonova, M. A., Pupyshev, A. B.

“…In an experimental model of Alzheimer’s disease in mice, oral administration of trehalose disaccharide reduces neuroinflammation assessed by the expression…”
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Restoration of Parkinson’s Disease-Like Deficits by Activating Autophagy through mTOR-Dependent and mTOR-Independent Mechanisms in Pharmacological and Transgenic Models of Parkinson’s Disease in Mice by Pupyshev, A. B., Tenditnik, M. V., Ovsyukova, M. V., Akopyan, A. A., Dubrovina, N. I., Tikhonova, M. A.

“…We studied the possibilities of inhibition of neurodegeneration in MPTP-induced model of Parkinson’s disease (PD) in C57Bl/6J mice and transgenic model of…”
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A Therapeutic Target for Inhibition of Neurodegeneration: Autophagy by Pupyshev, A. B., Korolenko, T. A., Tikhonova, M. A.

“…The role of autophagy in supporting cellular survival and inhibiting neurodegeneration in Alzheimer’s disease, Parkinson’s disease, and Huntington’s disease,…”
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A Therapeutic Target for Inhibition of Neurodegeneration: Autophagy by Pupyshev, A B, Korolenko, T A, Tikhonova, M A

“…The role of autophagy in cell survival and suppression of neurodegeneration was considered. We discussed its involvement in Alzheimer's, Parkinson's, and…”
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Hypolipidemic Effect of Mannan in Mice with Acute Lipemia Induced by Poloxamer 407 by Goncharova, N. V., Khrapova, M. V., Pupyshev, A. B., Korolenko, E. Ts, Nešéáková, Z., Korolenko, T. A.

“…We studied biological effects of mannan, a polysaccharide immunomodulator from C. albicans , that interacts with mannose receptor in vivo . It is shown that…”
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The regulatory role of cystatin C in autophagy and neurodegeneration by Korolenko, T. A., Shintyapina, A. B., Pupyshev, A. B., Akopyan, A. A., Russkikh, G. S., Dikovskaya, M. A., Vavilin, V. A., Zavjalov, E. L, Tikhonova, M. A., Amstislavskaya, T. G.

“…Autophagy is a dynamic cellular process involved in the turnover of proteins, protein complexes, and organelles through lysosomal degradation. It is…”
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Depression of Macrophages Modifies Serum Lipid Profile in Hyperlipidemia by Goncharova, N. V., Pupyshev, A. B., Filyushina, E. E., Loktev, K. V., Korolenko, E. Ts, Lushnikova, E. L., Molodykh, O. P., Korolenko, T. A., Churin, B. V.

“…Suppression of functional activity of macrophages by gadolinium chloride, suppressing the macrophage population and the endocytosis velocity, was studied in…”
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Sucrose-stimulated release of FITC-dextran into the bile in the dynamics of its storage and elimination from the liver by Pupyshev, A B, Maiborodina, V I

“…Stimulation of release of FITC-dextran endocytosed in the liver by an injection of hypertonic sucrose led to the appearance of a less pronounced and prolonged…”
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Effect of benz(a)pyrene and constant light exposure on rat liver lysosomes and biliary excretion of lysosomal enzymes by Pupyshev, A B, Gutina, E M, Fedina, R G, Michurina, S V, Shurlygina, A V, Verbitskaya, L V

“…Threefold administration of benz(a)pyrene in a dose of 20 mg/kg markedly stimulated biliary excretion of lysosomal enzymes from rat liver without signs of…”
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Effect of transitory ischemia on liver lysosomal apparatus in rats with different resistance to hypoxia by Grek, O R, Pupyshev, A B, Tikhonova, E V

“…We studied the state of lysosomal apparatus and pro- and antioxidant activity in the liver of rats with different resistance to hypoxia during postischemic…”
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Protective effect of enterosgel on rat liver lysosomes during cytostatic treatment by Grek, O R, Mishenina, S V, Pupyshev, A B

“…Polychemotherapy with a complex of cytostatics (cyclophosphamide, doxorubicin, vincristine, prednisolone) induces progressive damage to hepatocyte membranes,…”
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Multifactor clinical-laboratory valuation of endogenic intoxication in chronic hepatitis B by N. I. Khokhlova, N. P. Tolokonskaya, A. B. Pupyshev

“…For the determining of the role of clinical data and integral laboratory indices in the valuation of endogenic intoxication (EI) in chronic hepatitis B (HHB)…”
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Multiple Mechanisms of the Therapeutic Effect of Trehalose in Inhibition of Experimental Neurodegeneration by Pupyshev, A. B., Korolenko, T. A., Tikhonova, M. A.

“…The search for effective treatment for neurodegeneration implies attacking the multiple mechanisms of this pathology. Such properties were found in…”
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Some Advanced Biomarkers of Neurodegenerative Disorders: Focus on Cystatin C by Korolenko, T. A., Pupyshev, A. B., Belichenko, V. M., Tikhonova, M. A., Amstislavskaya, T. G.

“…The search for biological markers of neurodegenerative diseases, namely, Alzheimer’s (AD) and Parkinson’s (PD) diseases, is actual problem for fundamental…”
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EXTRACELLULAR VESICLES: INTERCELLULAR INFORMATION FLOW AND MEDICAL APPLICATIONS by Pupyshev, A B

“…The major features of extracellular vesicles secreted by mammalian cells are considered. Cell activation caused by formation of pathology stimulates the…”
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Serum albumin binding capacity values in the clinical evaluation of endogenous intoxication in acute viral hepatitis by Khokhlova, N I, Pupyshev, A B, Tolokonskaia, N P, Lapitskaia, N M, Gubareva, E A

“…The fluorescence technique was used to determine the effective albumin concentration (EAC) and albumin binding reserve (ABR) in 130 patients with acute viral…”
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Reparative autophagy and autophagy death of cells. Functional and regulatory aspects by Pupyshev, A B

“…Molecular regulation of reparative/homeostatic autophagy induced by failure of vital resources and by cellular stress is considered. Extensive autophagy…”
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Effects and Mechanisms of Rapamycin Action on Experimental Neurodegeneration by Pupyshev, A. B., Korolenko, T. A., Tikhonova, M. A.

“…Rapamycin is a strong inducer of autophagy which binds with its target protein mTOR and causes inhibition of biosynthetic and mitotic cell activities. The…”
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Lysosomal membrane permeabilization as apoptogenic factor by Pupyshev, A B

“…Lysosomal membrane labilizing agents (incl. proapoptotic proteins of Bcl-2 family, LAPF, p53), estimation of lysosomal membrane permeabilization in living…”
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Heterophagic function and rate of intralysosomal proteolysis during lysosomotropic agents administration by Korolenko, T A, Pupyshev, A B, Malygin, A E

“…Lysosomotropic agents--Triton WR 1339 and suramin--are taken up selectively into lysosomes during in vivo administration and cause specific changes of the…”
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