Search Results - "Pupa, SM"

New insights into the role of extracellular matrix during tumor onset and progression by Pupa, Serenella M., Ménard, Sylvie, Forti, Stefania, Tagliabue, Elda

“…Recently, a view of the tumor as a functional tissue interconnected with the microenvironment has recently been described. For many years, the stroma has been…”
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Biologic and therapeutic role of HER2 in cancer by Ménard, Sylvie, Pupa, Serenella Marja, Campiglio, Manuela, Tagliabue, Elda

“…Overexpression of the human epidermal growth factor-2 (HER2) oncogene in human breast carcinomas has been associated with a more aggressive course of disease…”
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Innovative therapy, monoclonal antibodies, and beyond: Highlights from the eighth annual meeting by De Santis, F., Del Vecchio, M., Castagnoli, L., De Braud, F., Di Cosimo, S., Franceschini, D., Fucà, G., Hiscott, J., Malmberg, K.J., McGranahan, N., Pietrantonio, F., Rivoltini, L., Sangaletti, S., Tagliabue, E., Tripodo, C., Vernieri, C., Zitvogel, L., Pupa, S.M., Di Nicola, M.

“…The eighth annual conference of “Innovative therapy, monoclonal antibodies, and beyond” was held in Milan on Jan. 26, 2018, and hosted by Fondazione…”
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Role of HER2 gene overexpression in breast carcinoma by Ménard, Sylvie, Tagliabue, Elda, Campiglio, Manuela, Pupa, Serenella M.

“…The HER2 proto‐oncogene encodes a transmembrane glycoprotein of 185 kDa (p185HER2) with intrinsic tyrosine kinase activity. Amplification of the HER2 gene and…”
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Abstract P5-18-10: Chemotherapy can enhance trastuzumab-mediated ADCC by Tagliabue, E, Sfondrini, L, Regondi, V, Casalini, P, Pupa, SM, Sommariva, M, Balsari, A, Triulzi, T

“…Trastuzumab, a recombinant humanized monoclonal antibody directed to the HER2 protein, has shown survival benefits in women with HER2-positive breast cancer,…”
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Role of exon-16-deleted HER2 in breast carcinomas by Castiglioni, F, Tagliabue, E, Campiglio, M, Pupa, S M, Balsari, A, Ménard, S

“…A splice variant of the human gene HER2, lacking exon-16 (ΔHER2) which encodes a small extracellular region, has been described. This altered receptor forms…”
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Electroporated DNA vaccine clears away multifocal mammary carcinomas in Her-2/neu transgenic mice by QUAGLINO, Elena, IEZZI, Manuela, LOLLINI, Pier Luigi, MUSIANI, Piero, FORNI, Guido, CAVALLO, Federica, MASTINI, Cristina, AMICI, Augusto, PERICLE, Federica, DI CARLO, Emma, PUPA, Serenella M, DE GIOVANNI, Carla, SPADARO, Michela, CURCIO, Claudia

“…The transforming rat Her-2/neu oncogene embedded into the genome of virgin transgenic BALB/c mice (BALB-neuT) provokes the development of an invasive carcinoma…”
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P5-14-06: Interaction between Stoma and Tumor Characteristics as a New Prognostic and Predictive Marker in Breast Carcinomas by Tagliabue, E, Sandri, M, Casalini, P, Aiello, P, Pupa, SM, Orlandi, R, Balsari, A, Triulzi, T

“…Background. We recently demonstrated that primary breast tumors can be classified based upon extracellular matrix composition (ECM) (Bergamaschi et al.)…”
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Combined allogeneic tumor cell vaccination and systemic interleukin 12 prevents mammary carcinogenesis in HER-2/neu transgenic mice by Nanni, P, Nicoletti, G, De Giovanni, C, Landuzzi, L, Di Carlo, E, Cavallo, F, Pupa, S M, Rossi, I, Colombo, M P, Ricci, C, Astolfi, A, Musiani, P, Forni, G, Lollini, P L

“…Transgenic Balb/c mice expressing the transforming rat HER-2/neu oncogene develop early and multifocal mammary carcinomas. Within the first 5 months of life…”
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The 67 kDa laminin receptor increases tumor aggressiveness by remodeling laminin-1 by Berno, V, Porrini, D, Castiglioni, F, Campiglio, M, Casalini, P, Pupa, S M, Balsari, A, Ménard, S, Tagliabue, E

“…The association between expression of the 67 kDa laminin receptor (67LR) and tumor aggressiveness has been convincingly demonstrated although the exact…”
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High-titer HER-2/neu protein-specific antibody can be detected in patients with early-stage breast cancer by Disis, M L, Pupa, S M, Gralow, J R, Dittadi, R, Menard, S, Cheever, M A

“…To evaluate HER-2/neu-specific antibody immunity in patients with breast cancer, to determine the rate of occurrence of serum antibodies to HER-2/neu in…”
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HER-2: A biomarker at the crossroads of breast cancer immunotherapy and molecular medicine by Pupa, Serenella M., Tagliabue, Elda, Ménard, Sylvie, Anichini, Andrea

“…The oncoprotein encoded by the HER‐2 oncogene is a member of the HER family of receptor tyrosine kinases and is actually the first successfully exploited…”
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Inhibition of mammary carcinoma development in HER-2/neu transgenic mice through induction of autoimmunity by xenogeneic DNA vaccination by PUPA, Serenella M, IEZZI, Manuela, DI CARLO, Emma, INVERNIZZI, Annamaria, CAVALLO, Federica, MEAZZA, Raffaella, COMES, Alberto, FERRINI, Silvano, MUSIANI, Piero, MENARD, Sylvie

“…Plasmid DNA vectors encoding the full-length (VR1012/HER-2-FL) or only the extracellular and transmembrane domains (VR1012/HER-2-ECD-TM) of human (h) HER-2/neu…”
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Immunological and pathobiological roles of fibulin-1 in breast cancer by PUPA, Serenella M, ARGRAVES, Scott W, MORTARINI, Roberta, ANICHINI, Andrea, MENARD, Sylvie, FORTI, Stefania, CASALINI, Patrizia, BERNO, Valeria, AGRESTI, Roberto, AIELLO, Piera, INVERNIZZI, Annamaria, BALDASSARI, Paola, OTWAL, Waleed

“…Fibulin-1 (Fbln-1) is an immunogenic breast cancer-related glycoprotein identified by serological analysis of cDNA expression library (SEREX) strategy. Here,…”
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Apoptosis induction by trastuzumab: possible role of the core biopsy intervention by Ménard, Sylvie, Pupa, Serenella M, Campiglio, Manuela, Campiglio, Manuella, Balsari, Andrea, Fagnoni, Francesco, Costa, Alberto, Tagliabue, Elda, Taglibue, Elda

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Identification of breast cancer-restricted antigens by antibody screening of SKBR3 cDNA library using a preselected patient's serum by FORTI, Stefania, SCANLAN, Matthew J, MENARD, Sylvie, INVERNIZZI, Annamaria, CASTIGLIONI, Fabio, PUPA, Sandro, AGRESTI, Roberto, FONTANELLI, Rosanna, MORELLI, Daniele, OLD, Lloyd J, PUPA, Serenella M

“…Screening of a breast cancer cDNA library from SKBR3 human breast cancer cells by SEREX (serological analysis of cDNA expression library) using a preselected…”
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Prevention of spontaneous neu-expressing mammary tumor development in mice transgenic for rat proto-neu by DNA vaccination by PUPA, S. M, INVERNIZZI, A. M, FORTI, S, DI CARLO, E, MUSIANI, P, NANNI, P, LOLLINI, P. L, MEAZZA, R, FERRINI, S, MENARD, S

“…The HER-2/neu proto-oncogene is overexpressed in 20-30% of human breast cancers and is associated with high recurrence risk. The oncogenic potential of…”
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The extracellular matrix composition and responsiveness to breast carcinoma therapy by Pupa, SM, Argraves, WS, Cotrupi, S, Giuffré, S, Castiglioni, F, Ménard, S, Tagliabue, E

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The extracellular domain of the c-erbB-2 oncoprotein is released from tumor cells by proteolytic cleavage by Pupa, S M, Ménard, S, Morelli, D, Pozzi, B, De Palo, G, Colnaghi, M I

“…A molecule that is immunologically related to the c-erbB-2 oncogene product (p185HER2/neu) was detected in the conditioned culture medium from…”
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Immunological and pathobiological roles of fibulin-1 in breast cancer by Pupa, Serenella M, Argraves, Scott W, Fo, Casalini, Patrizia, Berno, Valeria, Agresti, Roberto, Aiello, Piera, Invernizzi, Annamaria, Baldassari, Paola, Otwal, Waleed, Mortarini, Roberta, Anichini, Andrea, Menard, Sylvie

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