Search Results - "Punj, Vasu"

Re:GEN Open: The Impact of Genomics and Biotechnology on the Future of Medicine by Punj, Vasu

“…Modern technological advances, like the unraveling of the human genome, high-throughput cellular processes, etc., have ushered in an era with renewed hope for…”
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Transcriptional regulation of autophagy-lysosomal function in BRAF-driven melanoma progression and chemoresistance by Li, Shun, Song, Ying, Quach, Christine, Guo, Hongrui, Jang, Gyu-Beom, Maazi, Hadi, Zhao, Shihui, Sands, Nathaniel A., Liu, Qingsong, In, Gino K., Peng, David, Yuan, Weiming, Machida, Keigo, Yu, Min, Akbari, Omid, Hagiya, Ashley, Yang, Yongfei, Punj, Vasu, Tang, Liling, Liang, Chengyu

“…Autophagy maintains homeostasis and is induced upon stress. Yet, its mechanistic interaction with oncogenic signaling remains elusive. Here, we show that in…”
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NANOG Metabolically Reprograms Tumor-Initiating Stem-like Cells through Tumorigenic Changes in Oxidative Phosphorylation and Fatty Acid Metabolism by Chen, Chia-Lin, Uthaya Kumar, Dinesh Babu, Punj, Vasu, Xu, Jun, Sher, Linda, Tahara, Stanley M., Hess, Sonja, Machida, Keigo

“…Stem cell markers, including NANOG, have been implicated in various cancers; however, the functional contribution of NANOG to cancer pathogenesis has remained…”
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BMP signaling orchestrates a transcriptional network to control the fate of mesenchymal stem cells in mice by Feng, Jifan, Jing, Junjun, Li, Jingyuan, Zhao, Hu, Punj, Vasu, Zhang, Tingwei, Xu, Jian, Chai, Yang

“…Signaling pathways are used reiteratively in different developmental processes yet produce distinct cell fates through specific downstream transcription…”
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Plasminogen Activator Inhibitor-1 Promotes the Recruitment and Polarization of Macrophages in Cancer by Kubala, Marta Helena, Punj, Vasu, Placencio-Hickok, Veronica Rae, Fang, Hua, Fernandez, G. Esteban, Sposto, Richard, DeClerck, Yves Albert

“…Plasminogen activator inhibitor-1 (PAI-1) has a pro-tumorigenic function via its pro-angiogenic and anti-apoptotic activities. Here, we demonstrate that PAI-1…”
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p53 destabilizing protein skews asymmetric division and enhances NOTCH activation to direct self-renewal of TICs by Choi, Hye Yeon, Siddique, Hifzur R., Zheng, Mengmei, Kou, Yi, Yeh, Da-Wei, Machida, Tatsuya, Chen, Chia-Lin, Uthaya Kumar, Dinesh Babu, Punj, Vasu, Winer, Peleg, Pita, Alejandro, Sher, Linda, Tahara, Stanley M., Ray, Ratna B., Liang, Chengyu, Chen, Lin, Tsukamoto, Hidekazu, Machida, Keigo

“…Tumor-initiating stem-like cells (TICs) are defective in maintaining asymmetric cell division and responsible for tumor recurrence. Cell-fate-determinant…”
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MMP-9 facilitates selective proteolysis of the histone H3 tail at genes necessary for proficient osteoclastogenesis by Kim, Kyunghwan, Punj, Vasu, Kim, Jin-Man, Lee, Sunyoung, Ulmer, Tobias S, Lu, Wange, Rice, Judd C, An, Woojin

“…Although limited proteolysis of the histone H3 N-terminal tail (H3NT) is frequently observed during mammalian differentiation, the specific genomic sites…”
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Cooperation between SMYD3 and PC4 drives a distinct transcriptional program in cancer cells by Kim, Jin-Man, Kim, Kyunghwan, Schmidt, Thomas, Punj, Vasu, Tucker, Haley, Rice, Judd C, Ulmer, Tobias S, An, Woojin

“…SET and MYND domain containing protein 3 (SMYD3) is a histone methyltransferase, which has been implicated in cell growth and cancer pathogenesis. Increasing…”
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Pluripotency factor-mediated expression of the leptin receptor (OB-R) links obesity to oncogenesis through tumor-initiating stem cells by Feldman, Douglas Edmund, Chen, Chialin, Punj, Vasu, Tsukamoto, Hidekazu, Machida, Keigo

“…Misregulation of a pluripotency-associated transcription factor network in adult tissues is associated with the expansion of rare, highly malignant…”
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Genome-wide sperm deoxyribonucleic acid methylation is altered in some men with abnormal chromatin packaging or poor in vitro fertilization embryogenesis by Aston, Kenneth I., Ph.D, Punj, Vasu, Ph.D, Liu, Lihua, M.D, Carrell, Douglas T., Ph.D

“…Objective To evaluate genome-wide DNA methylation patterns in sperm from men with abnormal sperm chromatin packaging and patients displaying abnormal…”
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A truncating mutation in the autophagy gene UVRAG drives inflammation and tumorigenesis in mice by Quach, Christine, Song, Ying, Guo, Hongrui, Li, Shun, Maazi, Hadi, Fung, Marshall, Sands, Nathaniel, O’Connell, Douglas, Restrepo-Vassalli, Sara, Chai, Billy, Nemecio, Dali, Punj, Vasu, Akbari, Omid, Idos, Gregory E., Mumenthaler, Shannon M., Wu, Nancy, Martin, Sue Ellen, Hagiya, Ashley, Hicks, James, Cui, Hengmin, Liang, Chengyu

“…Aberrant autophagy is a major risk factor for inflammatory diseases and cancer. However, the genetic basis and underlying mechanisms are less established…”
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Linker histone H1.2 establishes chromatin compaction and gene silencing through recognition of H3K27me3 by Kim, Jin-Man, Kim, Kyunghwan, Punj, Vasu, Liang, Gangning, Ulmer, Tobias S., Lu, Wange, An, Woojin

“…Linker histone H1 is a protein component of chromatin and has been linked to higher-order chromatin compaction and global gene silencing. However, a growing…”
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NUMB phosphorylation destabilizes p53 and promotes self‐renewal of tumor‐initiating cells by a NANOG‐dependent mechanism in liver cancer by Siddique, Hifzur R., Feldman, Douglas E., Chen, Chia‐Lin, Punj, Vasu, Tokumitsu, Hiroshi, Machida, Keigo

“…Stem cell populations are maintained through self‐renewing divisions in which one daughter cell commits to a particular fate whereas the other retains the…”
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Genome-wide profiling identifies a DNA methylation signature that associates with TET2 mutations in diffuse large B-cell lymphoma by Asmar, Fazila, Punj, Vasu, Christensen, Jesper, Pedersen, Marianne T, Pedersen, Anja, Nielsen, Anders B, Hother, Christoffer, Ralfkiaer, Ulrik, Brown, Peter, Ralfkiaer, Elisabeth, Helin, Kristian, Grønbæk, Kirsten

“…The discovery that the Ten-Eleven Translocation (TET) hydroxylases cause DNA demethylation has fundamentally changed the notion of how DNA methylation is…”
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Regulation of Breast Cancer-Induced Osteoclastogenesis by MacroH2A1.2 Involving EZH2-Mediated H3K27me3 by Kim, Jinman, Shin, Yonghwan, Lee, Sunyoung, Kim, Miyeong, Punj, Vasu, Lu, Jason F., Shin, Hongin, Kim, Kyunghwan, Ulmer, Tobias S., Koh, Jungmin, Jeong, Daewon, An, Woojin

“…Breast cancer cells relocate to bone and activate osteoclast-induced bone resorption. Soluble factors secreted by breast cancer cells trigger a cascade of…”
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Derivation of induced pluripotent stem cells from ferret somatic cells by Gao, Jinghui, Petraki, Sophia, Sun, Xingshen, Brooks, Leonard A, Lynch, Thomas J, Hsieh, Chih-Lin, Elteriefi, Reem, Lorenzana, Zareeb, Punj, Vasu, Engelhardt, John F, Parekh, Kalpaj R, Ryan, Amy L

“…Ferrets are an attractive mammalian model for several diseases, especially those affecting the lungs, liver, brain, and kidneys. Many chronic human diseases…”
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Genome-wide analysis suggests a differential microRNA signature associated with normal and diabetic human corneal limbus by Kulkarni, Mangesh, Leszczynska, Aleksandra, Wei, Gabbie, Winkler, Michael A., Tang, Jie, Funari, Vincent A., Deng, Nan, Liu, Zhenqiu, Punj, Vasu, Deng, Sophie X., Ljubimov, Alexander V., Saghizadeh, Mehrnoosh

“…Small non-coding RNAs, in particular microRNAs (miRNAs), regulate fine-tuning of gene expression and can impact a wide range of biological processes. However,…”
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Nanoparticles in the treatment and diagnosis of neurological disorders: untamed dragon with fire power to heal by Kanwar, Jagat R., PhD, Sun, Xueying, PhD, Punj, Vasu, PhD, Sriramoju, Bhasker, MPharma, Mohan, Rajiv R., PhD, Zhou, Shu-Feng, PhD, Chauhan, Ashok, PhD, Kanwar, Rupinder K., PhD

“…Abstract The incidence of neurological diseases of unknown etiology is increasing, including well-studied diseases such as Alzhiemer's, Parkinson's, and…”
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Gene dysregulation by histone variant H2A.Z in bladder cancer by Kim, Kyunghwan, Punj, Vasu, Choi, Jongkyu, Heo, Kyu, Kim, Jin-Man, Laird, Peter W, An, Woojin

“…The incorporation of histone variants into nucleosomes is one of the main strategies that the cell uses to regulate the structure and function of chromatin…”
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A pilot genome-scale profiling of DNA methylation in sporadic pituitary macroadenomas: association with tumor invasion and histopathological subtype by Ling, Chao, Pease, Matthew, Shi, Lingling, Punj, Vasu, Shiroishi, Mark S, Commins, Deborah, Weisenberger, Daniel J, Wang, Kai, Zada, Gabriel

“…Pituitary adenomas (PAs) are neoplasms that may cause a variety of neurological and endocrine effects. Although known causal contributors include heredity,…”
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