Novel aminoalkyl tris-cyclometalated iridium complexes as cellular stains

Herein we report the synthesis and investigation of the properties of two tris-cyclometalated luminescent iridium complexes. These complexes are the simple derivatives of fac-[Ir(ppy) ] bearing amino alkyl groups on one of the phenylpyridine rings. The complexes are highly emissive and exhibit struc...

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Bibliographic Details
Published in:	Dalton transactions : an international journal of inorganic chemistry Vol. 45; no. 43; p. 17420
Main Authors:	Sansee, A, Meksawangwong, S, Chainok, K, Franz, K J, Gál, M, Pålsson, L-O, Puniyan, W, Traiphol, R, Pal, R, Kielar, F
Format:	Journal Article
Language:	English
Published:	England 01-11-2016
Subjects:	Aminopyridines - chemistry Animals Cell Membrane - metabolism Endocytosis Humans Iridium - chemistry Luminescence Luminescent Agents - chemistry Lysosomes - chemistry Mice Molecular Structure NIH 3T3 Cells Organometallic Compounds - chemical synthesis Organometallic Compounds - chemistry
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Summary:	Herein we report the synthesis and investigation of the properties of two tris-cyclometalated luminescent iridium complexes. These complexes are the simple derivatives of fac-[Ir(ppy) ] bearing amino alkyl groups on one of the phenylpyridine rings. The complexes are highly emissive and exhibit structured emission peaks in aqueous solution while having only broad unstructured emission in organic solvents. The complexes have been shown to be taken up by NIH-3T3 and PC3 cells, where they localize in the lysosomes and remain emissive with lifetimes in the microsecond domain.
ISSN:	1477-9234
DOI:	10.1039/c6dt02776h