Search Results - "Punetha, Ankita"

Advancements in Oncoproteomics Technologies: Treading toward Translation into Clinical Practice by Punetha, Ankita, Kotiya, Deepak

“…Proteomics continues to forge significant strides in the discovery of essential biological processes, uncovering valuable information on the identity, global…”
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ZifBASE: a database of zinc finger proteins and associated resources by Jayakanthan, Mannu, Muthukumaran, Jayaraman, Chandrasekar, Sanniyasi, Chawla, Konika, Punetha, Ankita, Sundar, Durai

“…Information on the occurrence of zinc finger protein motifs in genomes is crucial to the developing field of molecular genome engineering. The knowledge of…”
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In silico engineering of aggregation-prone recombinant proteins for substrate recognition by the chaperonin GroEL by Kumar, Vipul, Punetha, Ankita, Sundar, Durai, Chaudhuri, Tapan K

“…Molecular chaperones appear to have been evolved to facilitate protein folding in the cell through entrapment of folding intermediates on the interior of a…”
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Active site plasticity enables metal-dependent tuning of Cas5d nuclease activity in CRISPR-Cas type I-C system by Punetha, Ankita, Sivathanu, Raveendran, Anand, Baskaran

“…Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR) in association with CRISPR-associated (Cas) proteins constitutes a formidable defense system…”
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Inhibition of the NEMO/IKKβ association complex formation, a novel mechanism associated with the NF-κB activation suppression by Withania somnifera's key metabolite withaferin A by Grover, Abhinav, Shandilya, Ashutosh, Punetha, Ankita, Bisaria, Virendra S, Sundar, Durai

“…Nuclear Factor kappa B (NF-κB) is a transcription factor involved in the regulation of cell signaling responses and is a key regulator of cellular processes…”
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Discovery and Mechanistic Analysis of Structurally Diverse Inhibitors of Acetyltransferase Eis among FDA-Approved Drugs by Pang, Allan H., Green, Keith D., Punetha, Ankita, Thamban Chandrika, Nishad, Howard, Kaitlind C., Garneau-Tsodikova, Sylvie, Tsodikov, Oleg V.

“…Over one and a half million people die of tuberculosis (TB) each year. Multidrug-resistant TB infections are especially dangerous, and new drugs are needed to…”
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Discovery of substituted benzyloxy-benzylamine inhibitors of acetyltransferase Eis and their anti-mycobacterial activity by Pang, Allan H., Green, Keith D., Chandrika, Nishad Thamban, Garzan, Atefeh, Punetha, Ankita, Holbrook, Selina Y.L., Willby, Melisa J., Posey, James E., Tsodikov, Oleg V., Garneau-Tsodikova, Sylvie

“…A clinically significant mechanism of tuberculosis resistance to the aminoglycoside kanamycin (KAN) is its acetylation catalyzed by upregulated Mycobacterium…”
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A Role for Basigin in Toxoplasma gondii Infection by Nasuhidehnavi, Azadeh, Zhao, Yanlin, Punetha, Ankita, Hemphill, Andrew, Li, Hong, Bechtel, Tyler J, Rager, Theresa, Xiong, Bingcong, Petrou, Vasileios I, Gubbels, Marc-Jan, Weerapana, Eranthie, Yap, George S

“…The role of specific host cell surface receptors during Toxoplasma gondii invasion of host cells is poorly defined. Here, we interrogated the role of the…”
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Development of Single‐Stranded DNA Bisintercalating Inhibitors of Primase DnaG as Antibiotics by Green, Keith D., Punetha, Ankita, Chandrika, Nishad Thamban, Hou, Caixia, Garneau‐Tsodikova, Sylvie, Tsodikov, Oleg V.

“…Many essential enzymes in bacteria remain promising potential targets of antibacterial agents. In this study, we discovered that dequalinium, a topical…”
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Structure-Guided Optimization of Inhibitors of Acetyltransferase Eis from Mycobacterium tuberculosis by Punetha, Ankita, Ngo, Huy X, Holbrook, Selina Y L, Green, Keith D, Willby, Melisa J, Bonnett, Shilah A, Krieger, Kyle, Dennis, Emily K, Posey, James E, Parish, Tanya, Tsodikov, Oleg V, Garneau-Tsodikova, Sylvie

“…The enhanced intracellular survival (Eis) protein of ( ) is a versatile acetyltransferase that multiacetylates aminoglycoside antibiotics abolishing their…”
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EssOilDB: a database of essential oils reflecting terpene composition and variability in the plant kingdom by Kumari, Sangita, Pundhir, Sachin, Priya, Piyush, Jeena, Ganga, Punetha, Ankita, Chawla, Konika, Firdos Jafaree, Zohra, Mondal, Subhasish, Yadav, Gitanjali

“…Plant essential oils are complex mixtures of volatile organic compounds, which play indispensable roles in the environment, for the plant itself, as well as…”
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Abstract 5734: Designing RAF and MEK inhibitor combinations based on their biochemical properties to effectively target MAPK-driven cancers by Orive-Ramos, Ana, Adamopoulos, Christos, Baars, Beau, Lam, Jason, Punetha, Ankita, Huang, Jason, Petrou, Vasileios I., Aaronson, Stuart A., Poulikakos, Poulikos I.

“…Abstract Oncogenic alterations of the RAS/RAF/MEK/ERK signaling pathway drives growth of over 40% of human tumors, frequently due to activating mutations of…”
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Structure-based design of haloperidol analogues as inhibitors of acetyltransferase Eis from Mycobacterium tuberculosis to overcome kanamycin resistance by Punetha, Ankita, Green, Keith D., Garzan, Atefeh, Thamban Chandrika, Nishad, Willby, Melisa J., Pang, Allan H., Hou, Caixia, Holbrook, Selina Y. L., Krieger, Kyle, Posey, James E., Parish, Tanya, Tsodikov, Oleg V., Garneau-Tsodikova, Sylvie

“…Tuberculosis (TB), caused by Mycobacterium tuberculosis ( Mtb ), is a deadly bacterial disease. Drug-resistant strains of Mtb make eradication of TB a daunting…”
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Probing the Robustness of Inhibitors of Tuberculosis Aminoglycoside Resistance Enzyme Eis by Mutagenesis by Green, Keith D, Punetha, Ankita, Hou, Caixia, Garneau-Tsodikova, Sylvie, Tsodikov, Oleg V

“…Each year, millions of people worldwide contract tuberculosis (TB), the deadliest infection. The spread of infections with drug-resistant strains of…”
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Insight into the Enzyme-Inhibitor Interactions of the First Experimentally Determined Human Aromatase by Punetha, Ankita, Shanmugam, Karthi, Sundar, Durai

“…Aromatase is an important pharmacological target in the anti-cancer therapy as the intratumoral aromatase is the source of local estrogen production in breast…”
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Structure-based design of haloperidol analogues as inhibitors of acetyltransferase Eis from to overcome kanamycin resistance by Punetha, Ankita, Green, Keith D, Garzan, Atefeh, Thamban Chandrika, Nishad, Willby, Melisa J, Pang, Allan H, Hou, Caixia, Holbrook, Selina Y. L, Krieger, Kyle, Posey, James E, Parish, Tanya, Tsodikov, Oleg V, Garneau-Tsodikova, Sylvie

“…Tuberculosis (TB), caused by Mycobacterium tuberculosis ( Mtb ), is a deadly bacterial disease. Drug-resistant strains of Mtb make eradication of TB a daunting…”
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Inhibition of the NEMO/IKK[beta] association complex formation, a novel mechanism associated with the NF-[kappa]B activation suppression by Withania somnifera's key metabolite withaferin A by Grover, Abhinav, Shandilya, Ashutosh, Punetha, Ankita, Bisaria, Virendra S, Sundar, Durai

“…Abstract Background: Nuclear Factor kappa B (NF-κB) is a transcription factor involved in the regulation of cell signaling responses and is a key regulator of…”
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