The development of expandable films based on starch and chitosan for stomach-specific delivery of quercetin solid dispersions
Expandable films for stomach-specific delivery were developed to release quercetin, a flavonoid with in vivo gastroprotective effects, in a prolonged release fashion. We found that a solid dispersion containing quercetin and the hydrophilic polymers polyvinylpyrrolidone (PVP K30) at a 1:8 w/w ratio...
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| Published in: | Journal of drug delivery science and technology Vol. 95; p. 105631 |
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| Main Authors: | , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
Elsevier B.V
01-05-2024
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| Subjects: | |
| Online Access: | Get full text |
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| Summary: | Expandable films for stomach-specific delivery were developed to release quercetin, a flavonoid with in vivo gastroprotective effects, in a prolonged release fashion. We found that a solid dispersion containing quercetin and the hydrophilic polymers polyvinylpyrrolidone (PVP K30) at a 1:8 w/w ratio had approximately 1400-fold enhanced solubility (27.84 mg/mL). The quercetin solid dispersions were loaded into expandable starch/chitosan films by solvent casting method, which combined chitosan with various types of starch (pre-gelatinized maize starch, glutinous rice starch, and rice starch). We found that using pre-gelatinized maize starch-based film led to the optimized formulation. During an 8-h exposure to simulated stomach fluid, the formulation could unfold, swell, and release 80% of contained quercetin sustainably. Compared to indomethacin, the quercetin-loaded films exhibited a similar anti-inflammatory effect against RAW 264.7 macrophage cells in a dose-dependent manner. The obtained quercetin expandable films are promising as a stomach-specific delivery system.
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| ISSN: | 1773-2247 |
| DOI: | 10.1016/j.jddst.2024.105631 |