Search Results - "Pulsinelli, William A."

Metabolic and perfusion responses to recurrent peri-infarct depolarization during focal ischemia in the Spontaneously Hypertensive Rat: dominant contribution of sporadic CBF decrements to infarct expansion by Takeda, Yoshimasa, Zhao, Liang, Jacewicz, Michael, Pulsinelli, William A, Nowak, Thaddeus S

“…Peri-infarct depolarizations (PIDs) contribute to the evolution of focal ischemic lesions. Proposed mechanisms include both increased metabolic demand under…”
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Hypothermic Protection in Rat Focal Ischemia Models: Strain Differences and Relevance to "Reperfusion Injury" by Ren, Yubo, Hashimoto, Megumi, Pulsinelli, William A., Nowak, Thaddeus S.

“…Hypothermic protection was compared in Long-Evans and spontaneously hypertensive rat (SHR) strains using transient focal ischemia, and in Wistar and SHR…”
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Cerebral blood flow thresholds for mRNA synthesis after focal ischemia and the effect of MK-801 by KAMIYA, Tatsushi, JACEWICZ, Michael, NOWAK, Thaddeus S, PULSINELLI, William A

“…MK-801 is a noncompetitive antagonist of N-methyl-d-aspartate subtype glutamate receptors with protective efficacy in experimental stroke. This study examined…”
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Glucocorticoids Potentiate Ischemic Injury to Neurons: Therapeutic Implications by Sapolsky, Robert M., Pulsinelli, William A.

“…Sustained exposure to glucocorticoids, the adrenocortical stress hormones, is toxic to neurons, and such toxicity appears to play a role in neuron loss during…”
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Transient cooling during early reperfusion attenuates delayed edema and infarct progression in the Spontaneously Hypertensive Rat. Distribution and time course of regional brain temperature change in a model of postischemic hypothermic protection by Kurasako, Toshiaki, Zhao, Liang, Pulsinelli, William A, Nowak, Thaddeus S

“…The temperature threshold for protection by brief postischemic cooling was evaluated in a model of transient focal ischemia in the Spontaneously Hypertensive…”
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The ischemic penumbra, injury thresholds, and the therapeutic window for acute stroke by Ginsberg, M D, Pulsinelli, W A

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Selective Glial Vulnerability following Transient Global Ischemia in Rat Brain by Petito, Carol Kaiser, Olarte, John-Paul, Roberts, Brenda, Nowak, Thaddeus S, Pulsinelli, William A

“…Global cerebral ischemia selectively damages neurons, but its contribution to glial cell death is uncertain. Accordingly, adult male. rats were sacrificed by…”
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Switch in Glutamate Receptor Subunit Gene Expression in CA1 Subfield of Hippocampus Following Global Ischemia in Rats by Pellegrini-Giampietro, Domenico E., Zukin, R. Suzanne, Michael V. L. Bennett, Cho, Sunghee, Pulsinelli, William A.

“…Severe, transient global ischemia of the brain induces delayed damage to specific neuronal populations. Sustained Ca2+influx through glutamate receptor…”
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Depolarization thresholds for hippocampal damage, ischemic preconditioning, and changes in gene expression after global ischemia in the rat by Halaby, Issam A., Takeda, Yoshimasa, Yufu, Katsumi, Nowak, Thaddeus S., Pulsinelli, William A.

“…Induced ischemic tolerance in rat hippocampus was investigated in a forebrain ischemia model of repeated 4-vessel occlusion (4-VO). Ischemic insult variability…”
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Delayed hippocampal damage in humans following cardiorespiratory arrest by PETITO, C. K, FELDMANN, E, PULSINELLI, W. A, PLUM, F

“…Transient ischemia in animals produces delayed cell death in vulnerable hippocampal neurons. To see if this occurs in humans, we reexamined brain slides from…”
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Temporal profile of neuronal damage in a model of transient forebrain ischemia by Pulsinelli, W A, Brierley, J B, Plum, F

“…This study examined the temporal profile of ischemic neuronal damage following transient bilateral forebrain ischemia in the rat model of four-vessel…”
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The CBF threshold and dynamics for focal cerebral infarction in spontaneously hypertensive rats by Jacewicz, M, Tanabe, J, Pulsinelli, W A

“…Two strategies were used to estimate the blood flow threshold for focal cerebral infarction in spontaneously hypertensive rats (SHRs) subjected to permanent…”
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NMDA and non-NMDA receptor gene expression following global brain ischemia in rats: effect of NMDA and non-NMDA receptor antagonists by Pellegrini-Giampietro, D E, Pulsinelli, W A, Zukin, R S

“…Transient forebrain or global ischemia in rats induces selective and delayed damage of hippocampal CA1 neurons. In a previous study, we have shown that…”
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Altered mitochondrial respiration in selectively vulnerable brain subregions following transient forebrain ischemia in the rat by Sims, N R, Pulsinelli, W A

“…Mitochondrial respiratory function, assessed from the rate of oxygen uptake by homogenates of rat brain subregions, was examined after 30 min of forebrain…”
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Electrophysiological changes of CA3 neurons and dentate granule cells following transient forebrain ischemia by Howard, Eugene M, Gao, Tian-Ming, Pulsinelli, William A, Xu, Zao C

“…The electrophysiological responses of CA3 pyramidal neurons and dentate granule (DG) cells in rat hippocampus were studied after transient forebrain ischemia…”
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Regional cerebral blood flow and glucose metabolism following transient forebrain ischemia by Pulsinelli, W A, Levy, D E, Duffy, T E

“…Progressive brain damage after transient cerebral ischemia may be related to changes in postischemic cerebral blood flow and metabolism. Regional cerebral…”
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Hydrogen ions kill brain at concentrations reached in ischemia by Kraig, R P, Petito, C K, Plum, F, Pulsinelli, W A

“…Elevation of brain glucose before the onset of nearly complete ischemia leads to increased lactic acid within brain. When excessive, such acidosis may be a…”
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The effects of extracellular acidosis on neurons and glia in vitro by Goldman, S A, Pulsinelli, W A, Clarke, W Y, Kraig, R P, Plum, F

“…Cerebral lactic acid, a product of ischemic anaerobic glycolysis, may directly contribute to ischemic brain damage in vivo. In this study we evaluated the…”
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Continuous nimodipine treatment attenuates cortical infarction in rats subjected to 24 hours of focal cerebral ischemia by Jacewicz, M, Brint, S, Tanabe, J, Pulsinelli, W A

“…Focal cerebral infarction and edema were measured in rats (Wistar, Fisher 344, and spontaneously hypertensive strains) pretreated with nimodipine (2…”
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Severe bilateral tremor in a liver transplant recipient taking cyclosporine by Ledoux, Mark S., McGill, Lora J., Pulsinelli, William A., Pfeiffer, Ronald F., Deuschl, Günther, Siderowf, Andrew, Kurlan, Roger, Sethi, Kapil

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