Search Results - "Pulmonary pharmacology & therapeutics"

Lung cancer in patients with idiopathic pulmonary fibrosis by Karampitsakos, Theodoros, Tzilas, Vasilios, Tringidou, Rodoula, Steiropoulos, Paschalis, Aidinis, Vasilis, Papiris, Spyros A, Bouros, Demosthenes, Tzouvelekis, Argyris

“…Abstract Idiopathic pulmonary fibrosis (IPF) is a chronic fibrotic lung disease of unknown etiology. With a gradually increasing worldwide prevalence and a…”
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Dual-histamine receptor blockade with cetirizine - famotidine reduces pulmonary symptoms in COVID-19 patients by Hogan II, Reed B., Hogan III, Reed B., Cannon, Tim, Rappai, Maria, Studdard, John, Paul, Doug, Dooley, Thomas P.

“…The COVID-19 pandemic due to SARS-CoV-2 infection can produce Acute Respiratory Distress Syndrome as a result of a pulmonary cytokine storm. Antihistamines are…”
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The immunomodulatory effects of macrolide antibiotics in respiratory disease by Pollock, Jennifer, Chalmers, James D.

“…Macrolide antibiotics are well known for their antibacterial properties, but extensive research in the context of inflammatory lung disease has revealed that…”
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Sequential doxycycline and colchicine combination therapy in Covid-19: The salutary effects by Al-kuraishy, Hayder M., Al-Gareeb, Ali I., Qusty, Naeem, Cruz-Martins, Natália, El-Saber Batiha, Gaber

“…Coronavirus virus disease 2019 (COVID-19) is a viral infectious disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), actually…”
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Myricetin inhibits TNF-α-induced inflammation in A549 cells via the SIRT1/NF-κB pathway by Chen, Min, Chen, Ziyu, Huang, Dan, Sun, Chaoqun, Xie, Jinye, Chen, Tingting, Zhao, Xuanna, Huang, Yujie, Li, Dongming, Wu, Bin, Wu, Dong

“…Although myricetin exerts anti-inflammation, anti-cancer, and anti-oxidation effects, the relationship between myricetin and tumor necrosis factor alpha…”
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Use of animal models in IPF research by Carrington, R., Jordan, S., Pitchford, S.C., Page, C.P.

“…Idiopathic pulmonary fibrosis (IPF) is a fatal interstitial lung disease with a poor prognosis and limited treatment options. Many compounds have shown…”
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BLU-5937: A selective P2X3 antagonist with potent anti-tussive effect and no taste alteration by Garceau, Denis, Chauret, Nathalie

“…BLU-5937 is a small molecule that was shown to be a potent, selective and non-competitive P2X3 homotrimeric receptor antagonist. P2X3 receptors are ATP…”
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Reslizumab in patients with inadequately controlled late-onset asthma and elevated blood eosinophils by Brusselle, Guy, Germinaro, Matthew, Weiss, Sivan, Zangrilli, James

“…Abstract Introduction Asthma with adult onset and elevated blood eosinophils is a difficult-to-treat subgroup. This post hoc analysis evaluated reslizumab, an…”
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One year of mepolizumab. Efficacy and safety in real-life in Italy by Bagnasco, Diego, Caminati, Marco, Menzella, Francesco, Milanese, Manlio, Rolla, Giovanni, Lombardi, Carlo, Bucca, Caterina, Heffler, Enrico, Paoletti, Giovanni, Testino, Elisa, Manfredi, Andrea, Caruso, Cristiano, Guida, Giuseppe, Senna, Gianenrico, Bonavia, Marco, Riccio, Anna Maria, Canonica, Giorgio Walter, Passalacqua, Giovanni

“…Severe asthma is a disease with a heavy socio-economic burden and a relevant impact on the life of patients. Mepolizumab (MEP) was recently introduced in…”
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Pirfenidone, nintedanib and N -acetylcysteine for the treatment of idiopathic pulmonary fibrosis: A systematic review and meta-analysis by Rogliani, Paola, Calzetta, Luigino, Cavalli, Francesco, Matera, Maria Gabriella, Cazzola, Mario

“…Abstract Background The prevalence of idiopathic pulmonary fibrosis (IPF) is increasing every year. Pirfenidone and nintedanib were approved for treatment of…”
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Randomized controlled trials and real life studies. Approaches and methodologies: a clinical point of view by Saturni, S, Bellini, F, Braido, F, Paggiaro, P, Sanduzzi, A, Scichilone, N, Santus, P.A, Morandi, L, Papi, A

“…Abstract Randomized Controlled Trials (RCTs) are the “gold standard” for evaluating treatment outcomes providing information on treatments “efficacy”. They are…”
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Antihistamines and azithromycin as a treatment for COVID-19 on primary health care – A retrospective observational study in elderly patients by Morán Blanco, Juan Ignacio, Alvarenga Bonilla, Judith A., Homma, Sakae, Suzuki, Kazuo, Fremont-Smith, Philip, Villar Gómez de las Heras, Karina

“…Between March and April 2020, 84 elderly patients with suspected COVID-19 living in two nursing homes of Yepes, Toledo (Spain) were treated early with…”
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Vitamin D prevents experimental lung fibrosis and predicts survival in patients with idiopathic pulmonary fibrosis by Tzilas, Vasilios, Bouros, Evangelos, Barbayianni, Ilianna, Karampitsakos, Thodoris, Kourtidou, Sofia, Ntassiou, Maria, Ninou, Ioanna, Aidinis, Vassilis, Bouros, Demosthenes, Tzouvelekis, Argyris

“…Vitamin D (VitD) is a steroid hormone with cytoprotective and anti-inflammatory properties. Epidemiological studies have suggested a link between VitD…”
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Exploring the monocrotaline animal model for the study of pulmonary arterial hypertension: A network approach by Nogueira-Ferreira, Rita, Vitorino, Rui, Ferreira, Rita, Henriques-Coelho, Tiago

“…Abstract Pulmonary arterial hypertension (PAH) is responsible for the premature death mainly because of progressive and severe heart failure. This disease is…”
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Mepolizumab effectiveness on small airway obstruction, corticosteroid sparing and maintenance therapy step-down in real life by Sposato, Bruno, Camiciottoli, Gianna, Bacci, Elena, Scalese, Marco, Carpagnano, Giovanna Elisiana, Pelaia, Corrado, Santus, Pierachille, Maniscalco, Mauro, Masieri, Simonetta, Corsico, Angelo, Scichilone, Nicola, Baglioni, Stefano, Murgia, Nicola, Folletti, Ilenia, Bardi, Giulio, Grosso, Amelia, Cameli, Paolo, Latorre, Manuela, Musarra, Antonino, Bargagli, Elena, Ricci, Alberto, Pelaia, Girolamo, Paggiaro, Pierluigi, Rogliani, Paola

“…Mepolizumab (MEP) has been recently introduced to treat severe eosinophilic asthma. Trials have demonstrated a significant effectiveness in this asthma…”
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Cough and airway disease: The role of ion channels by Bonvini, Sara J., Belvisi, Maria G.

“…Cough is the most common reason for patients to visit a primary care physician, yet it remains an unmet medical need. It can be idiopathic in nature but can…”
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The anti-inflammatory effects of cannabidiol and cannabigerol alone, and in combination by Robaina Cabrera, Carmen Lorena, Keir-Rudman, Sandra, Horniman, Nick, Clarkson, Nick, Page, Clive

“…Studies with Cannabis Sativa plant extracts and endogenous agonists of cannabinoid receptors have demonstrated anti-inflammatory, bronchodilator, and…”
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Renin-angiotensin-system, a potential pharmacological candidate, in acute respiratory distress syndrome during mechanical ventilation by Wang, Di, Chai, Xiao-qing, Magnussen, Costan G., Zosky, Graeme R., Shu, Shu-hua, Wei, Xin, Hu, Shan-shan

“…While effective treatments for acute respiratory distress syndrome (ARDS) are lacking, mechanical lung ventilation can sustain adequate gas exchange in…”
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The oral CRTh2 antagonist QAW039 (fevipiprant): A phase II study in uncontrolled allergic asthma by Erpenbeck, Veit J, Popov, Todor A, Miller, David, Weinstein, Steven F, Spector, Sheldon, Magnusson, Baldur, Osuntokun, Wande, Goldsmith, Paul, Weiss, Markus, Beier, Jutta

“…Abstract Background There is an unmet medical need for allergic asthma patients who are uncontrolled on conventional therapies. The aim of this study was to…”
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Tofacitinib reduces mortality in coronavirus disease 2019 Tofacitinib in COVID-19 by Maslennikov, Roman, Ivashkin, Vladimir, Vasilieva, Ekaterina, Chipurik, Maxim, Semikova, Polina, Semenets, Victoria, Russkova, Tatyana, Levshina, Anna, Grigoriadis, Diana, Magomedov, Shamil, Efremova, Irina, Dzhakhaya, Natiya

“…Cytokine release syndrome is a dangerous complication of the coronavirus disease 2019 (COVID-19). This study aimed to evaluate the efficacy and safety of…”
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