Search Results - "Pullum, Derek"

Intranasal nanoemulsion-adjuvanted HSV-2 subunit vaccine is effective as a prophylactic and therapeutic vaccine using the guinea pig model of genital herpes by Bernstein, David I, Cardin, Rhonda D, Bravo, Fernando J, Hamouda, Tarek, Pullum, Derek A, Cohen, Gary, Bitko, Vira, Fattom, Ali

“…AbstractGenital herpes is a sexually transmitted disease representing a major global health concern. Currently, there is no approved vaccine and existing…”
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Duration of protection from live attenuated vs. sub unit HSV-2 vaccines in the guinea pig model of genital herpes: Reassessing efficacy using endpoints from clinical trials by Bernstein, David I, Cardin, Rhonda D, Pullum, Derek A, Bravo, Fernando J, Kousoulas, Konstantin G, Dixon, David A

“…Although herpes simplex viruses (HSV) are a major target for vaccine development no vaccine is currently licensed. A live attenuated HSV virus vaccine, VC2 was…”
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The HSV-1 live attenuated VC2 vaccine provides protection against HSV-2 genital infection in the guinea pig model of genital herpes by Bernstein, David I., Pullum, Derek A., Cardin, Rhonda D., Bravo, Fernando J., Dixon, David A., Kousoulas, Konstantin G.

“…Although development of an HSV vaccine is a priority there is currently no vaccine available. The recent failure of subunit vaccines suggest that presentation…”
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Replication-defective lymphocytic choriomeningitis virus vectors expressing guinea pig cytomegalovirus gB and pp65 homologs are protective against congenital guinea pig cytomegalovirus infection by Cardin, Rhonda D, Bravo, Fernando J, Pullum, Derek A, Orlinger, Klaus, Watson, Elizabeth M, Aspoeck, Andreas, Fuhrmann, Gerhard, Guirakhoo, Farshad, Monath, Thomas, Bernstein, David I

“…Abstract Background Congenital cytomegalovirus infection can be life-threatening and often results in significant developmental deficits and/or hearing loss…”
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Transcriptional repression by the HDAC4–RelB–p52 complex regulates multiple myeloma survival and growth by Vallabhapurapu, Subrahmanya D., Noothi, Sunil K., Pullum, Derek A., Lawrie, Charles H., Pallapati, Rachel, Potluri, Veena, Kuntzen, Christian, Khan, Sohaib, Plas, David R., Orlowski, Robert Z., Chesi, Marta, Kuehl, W. Michael, Bergsagel, P. Leif, Karin, Michael, Vallabhapurapu, Sivakumar

“…Although transcriptional activation by NF-κB is well appreciated, physiological importance of transcriptional repression by NF-κB in cancer has remained…”
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Successful application of prime and pull strategy for a therapeutic HSV vaccine by Bernstein, David I., Cardin, Rhonda D., Bravo, Fernando J., Awasthi, Sita, Lu, Peiwen, Pullum, Derek A., Dixon, David A., Iwasaki, Akiko, Friedman, Harvey M.

“…One promising approach for a herpes simplex virus vaccine uses a vaccine to prime and a chemoattractant to pull immune cells into the genital tract. We…”
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Efficacy of N-methanocarbathymidine against genital herpes simplex virus type 2 shedding and infection in guinea pigs by Bernstein, David I, Bravo, Fernando J, Pullum, Derek A, Shen, Hui, Wang, Mei, Rahman, Aquilur, Glazer, Robert I, Cardin, Rhonda D

“…Background Current approved nucleoside therapies for genital herpes simplex virus (HSV) infections are effective but improved therapies are needed for…”
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Alterations in the Host Defense Properties of Human Milk Following Prolonged Storage or Pasteurization by Akinbi, Henry, Meinzen‐Derr, Jareen, Auer, Christine, Ma, Yan, Pullum, Derek, Kusano, Ryosuke, Reszka, Krzysztof J, Zimmerly, Kira

“…ABSTRACT Objectives: Preterm infants are often fed pasteurized donor milk or mother's milk that has been stored frozen for up to 4 weeks. Our objectives were…”
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