Search Results - "Pullin, Robert D.C."

Dehydromicrosclerodermin B and Microsclerodermin J: Total Synthesis and Structural Revision by Melikhova, Ekaterina Y., Pullin, Robert D. C., Winter, Christian, Donohoe, Timothy J.

“…The total synthesis of dehydromicrosclerodermin B and microsclerodermin J is described. Efficient approaches to the unusual amino acids in the target molecules…”
Get full text

Oxidative cyclization for the synthesis of complex tetrahydrofuran-containing natural products by Pullin, Robert D. C., Lipiński, Radosław M., Donohoe, Timothy J.

“…The osmium-catalyzed oxidative cyclization of vicinal diols onto proximal olefins to generate 2,5- -substituted tetrahydrofurans (THFs) has been exploited as…”
Get full text

Desymmetrization of meso-bisphosphates via rhodium catalyzed asymmetric allylic arylation by Jacques, Reece, Hell, Alexander M.L., Pullin, Robert D.C., Fletcher, Stephen P.

“…The desymmetrization of meso-compounds allows for the unmasking of previously installed stereogenic centers, and quaternary centers are of special interest as…”
Get full text

Desymmetrization of meso-bisphosphates using copper catalysis and alkylzirconocene nucleophiles by Jacques, Reece, Pullin, Robert D. C., Fletcher, Stephen P.

“…The desymmetrization of meso -compounds is a useful synthetic method, as illustrated by numerous applications of this strategy in natural product synthesis…”
Get full text

Diastereoselective synthesis of the 5-hydroxy-pyrrolidinone amino acid of the microsclerodermins and model studies for an end-game strategy for microsclerodermin B by Winter, Christian, Pullin, Robert D.C., Donohoe, Timothy J.

“…[Display omitted] •Diastereoselective synthesis of amino acids from the microsclerodermins.•A pyrrolidinone amino acid was made by alkene hydration in two…”
Get full text

Diverse saturated heterocycles from a hydroacylation/conjugate addition cascade by Iwumene, Ndidi U. N, Moseley, Daniel. F, Pullin, Robert D. C, Willis, Michael C

“…Rhodium-catalyzed hydroacylation using alkynes substituted with pendant nucleophiles, delivers linear α,β-unsaturated enone intermediates with excellent…”
Get full text

Tertiary amine-promoted enone aziridination: investigations into factors influencing enantioselective induction by Armstrong, Alan, Pullin, Robert D.C., Jenner, Chloe R., Foo, Klement, White, Andrew J.P., Scutt, James N.

“…trans-N-Unsubstituted aziridines were synthesised (up to 77% ee) via a chiral tertiary amine-promoted nucleophilic aziridination of α,β-unsaturated ketones…”
Get full text

Natural product synthesis as a challenging test of newly developed methodology by Donohoe, Timothy J, Pullin, Robert D C

“…This article describes the examination of several synthetic methodologies that have been developed in our laboratories, by application to the construction of a…”
Get more information

Tethered Aminohydroxylation: Synthesis of the β‑Amino Acid of Microsclerodermins A and B by Pullin, Robert D. C, Rathi, Akshat H, Melikhova, Ekaterina Y, Winter, Christian, Thompson, Amber L, Donohoe, Timothy J

“…The utility of the tethered aminohydroxylation (TA) has been demonstrated by synthesis of the complex β-amino acid residue of microsclerodermins A and B. The…”
Get full text

Amine-Promoted Synthesis of Vinyl Aziridines by Armstrong, Alan, Pullin, Robert D. C, Jenner, Chloe R, Scutt, James N

“…N-Unsubstituted vinyl aziridines were synthesized via an amine-promoted regioselective nucleophilic aziridination of α,β,γ,δ-unsaturated carbonyl compounds…”
Get full text

One-pot near-ambient temperature syntheses of aryl(difluoroenol) derivatives from trifluoroethanol by Kyne, Sara H, Percy, Jonathan M, Pullin, Robert D C, Redmond, Joanna M, Wilson, Peter G

“…Difluoroalkenylzinc reagents prepared from 1-(2'-methoxy-ethoxymethoxy)-2,2,2-trifluoroethane and 1-(N,N-diethylcarbamoyloxy)-2,2,2-trifluoroethane at ice bath…”
Get more information

Silenes in organic synthesis: a concise synthesis of (+/-) -epi-picropodophyllin by Pullin, Robert D C, Sellars, Jonathan D, Steel, Patrick G

“…A concise, seven step synthesis of the aryl tetralin lignan lactone epi-picropodophyllin from piperonal is described. The key steps are a silene diene…”
Get more information

Hosomi-Sakurai reactions of silacyclohexenes by Hughes, Nicholas J, Pullin, Robert D C, Sanganee, Mahesh J, Sellars, Jonathan D, Steel, Patrick G, Turner, Michael J

“…Silacyclic allyl silanes, derived from silene-diene Diels-Alder reactions, combine with acetals in the presence of Lewis acids to afford, following oxidation…”
Get more information