Search Results - "Pullen, Timothy J."

Pancreatic β-cell identity, glucose sensing and the control of insulin secretion by Rutter, Guy A, Pullen, Timothy J, Hodson, David J, Martinez-Sanchez, Aida

“…Insulin release from pancreatic β-cells is required to maintain normal glucose homoeostasis in man and many other animals. Defective insulin secretion…”
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miR-29a and miR-29b Contribute to Pancreatic β-Cell-Specific Silencing of Monocarboxylate Transporter 1 (Mct1) by Pullen, Timothy J., da Silva Xavier, Gabriela, Kelsey, Gavin, Rutter, Guy A.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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The mitochondrial Ca2+ uniporter MCU is essential for glucose-induced ATP increases in pancreatic β-cells by Tarasov, Andrei I, Semplici, Francesca, Ravier, Magalie A, Bellomo, Elisa A, Pullen, Timothy J, Gilon, Patrick, Sekler, Israel, Rizzuto, Rosario, Rutter, Guy A

“…Glucose induces insulin release from pancreatic β-cells by stimulating ATP synthesis, membrane depolarisation and Ca(2+) influx. As well as activating…”
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The pore-forming subunit MCU of the mitochondrial Ca2+ uniporter is required for normal glucose-stimulated insulin secretion in vitro and in vivo in mice by Georgiadou, Eleni, Haythorne, Elizabeth, Dickerson, Matthew T., Lopez-Noriega, Livia, Pullen, Timothy J., da Silva Xavier, Gabriela, Davis, Samuel P. X., Martinez-Sanchez, Aida, Semplici, Francesca, Rizzuto, Rosario, McGinty, James A., French, Paul M., Cane, Matthew C., Jacobson, David A., Leclerc, Isabelle, Rutter, Guy A.

“…Aims/hypothesis Mitochondrial oxidative metabolism is central to glucose-stimulated insulin secretion (GSIS). Whether Ca 2+ uptake into pancreatic beta cell…”
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Calcium-insensitive splice variants of mammalian E1 subunit of 2-oxoglutarate dehydrogenase complex with tissue-specific patterns of expression by Denton, Richard M, Pullen, Timothy J, Armstrong, Craig T, Heesom, Kate J, Rutter, Guy A

“…The 2-oxoglutarate dehydrogenase (OGDH) complex is an important control point in vertebrate mitochondrial oxidative metabolism, including in the citrate cycle…”
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Could lncRNAs contribute to β-cell identity and its loss in Type 2 diabetes? by Pullen, Timothy J, Rutter, Guy A

“…The progression of Type 2 diabetes is accompanied by diminishing islet β-cell mass and function. It has been proposed that β-cells are lost not only through…”
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Roles of lncRNAs in pancreatic beta cell identity and diabetes susceptibility by Pullen, Timothy J, Rutter, Guy A

“…Type 2 diabetes usually ensues from the inability of pancreatic beta cells to compensate for incipient insulin resistance. The loss of beta cell mass,…”
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Carbohydrate-Responsive Element-Binding Protein (ChREBP) Is a Negative Regulator of ARNT/HIF-1β Gene Expression in Pancreatic Islet β-Cells by NOORDEEN, Nafeesa A, KHERA, Tarnjit K, GAO SUN, REBECCA LONGBOTTOM, E, PULLEN, Timothy J, DA SILVA XAVIER, Gabriela, RUTTER, Guy A, LECLERC, Isabelle

“…Carbohydrate-Responsive Element-Binding Protein (ChREBP) Is a Negative Regulator of ARNT/HIF-1β Gene Expression in Pancreatic Islet β-Cells Nafeesa A. Noordeen…”
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Identification of genes selectively disallowed in the pancreatic islet by Pullen, Timothy J., Khan, Arshad M., Barton, Geraint, Butcher, Sarah A., Sun, Gao, Rutter, Guy A.

“…We have previously identified two genes, encoding lactate dehydrogenase (Ldha) and the monocarboxylate carrier, MCT1 (Slc16a1) whose expression is remarkably…”
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Metabolic and functional specialisations of the pancreatic beta cell: gene disallowance, mitochondrial metabolism and intercellular connectivity by Rutter, Guy A., Georgiadou, Eleni, Martinez-Sanchez, Aida, Pullen, Timothy J.

“…All forms of diabetes mellitus involve the loss or dysfunction of pancreatic beta cells, with the former predominating in type 1 diabetes and the latter in…”
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The role of long non-coding RNAs in the regulation of pancreatic beta cell identity by Wilson, Maya E, Pullen, Timothy J

“…Type 2 diabetes (T2D) is a widespread disease affecting millions in every continental population. Pancreatic β-cells are central to the regulation of…”
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Local and regional control of calcium dynamics in the pancreatic islet by Rutter, Guy A., Hodson, David J., Chabosseau, Pauline, Haythorne, Elizabeth, Pullen, Timothy J., Leclerc, Isabelle

“…Ca2+ is the key intracellular regulator of insulin secretion, acting in the β‐cell as the ultimate trigger for exocytosis. In response to high glucose,…”
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Analysis of Purified Pancreatic Islet Beta and Alpha Cell Transcriptomes Reveals 11β-Hydroxysteroid Dehydrogenase (Hsd11b1) as a Novel Disallowed Gene by Pullen, Timothy J, Huising, Mark O, Rutter, Guy A

“…We and others have previously identified a group of genes, dubbed "disallowed," whose expression is markedly lower in pancreatic islets than in other mammalian…”
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The transcription factor Pax6 is required for pancreatic β cell identity, glucose-regulated ATP synthesis, and Ca2+ dynamics in adult mice by Mitchell, Ryan K., Nguyen-Tu, Marie-Sophie, Chabosseau, Pauline, Callingham, Rebecca M., Pullen, Timothy J., Cheung, Rebecca, Leclerc, Isabelle, Hodson, David J., Rutter, Guy A.

“…Heterozygous mutations in the human paired box gene PAX6 lead to impaired glucose tolerance. Although embryonic deletion of the Pax6 gene in mice leads to loss…”
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Replication and cross-validation of type 2 diabetes subtypes based on clinical variables: an IMI-RHAPSODY study by Slieker, Roderick C., Donnelly, Louise A., Fitipaldi, Hugo, Bouland, Gerard A., Giordano, Giuseppe N., Åkerlund, Mikael, Gerl, Mathias J., Ahlqvist, Emma, Ali, Ashfaq, Dragan, Iulian, Festa, Andreas, Hansen, Michael K., Mansour Aly, Dina, Kim, Min, Kuznetsov, Dmitry, Mehl, Florence, Klose, Christian, Simons, Kai, Pavo, Imre, Pullen, Timothy J., Suvitaival, Tommi, Wretlind, Asger, Rossing, Peter, Lyssenko, Valeriya, Legido-Quigley, Cristina, Groop, Leif, Thorens, Bernard, Franks, Paul W., Ibberson, Mark, Rutter, Guy A., Beulens, Joline W. J., ‘t Hart, Leen M., Pearson, Ewan R.

“…Aims/hypothesis Five clusters based on clinical characteristics have been suggested as diabetes subtypes: one autoimmune and four subtypes of type 2 diabetes…”
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Intracellular Positioning of Isoforms Explains an Unusually Large Adenylate Kinase Gene Family in the Parasite Trypanosoma brucei[boxs] by Ginger, Michael L., Ngazoa, E. Solange, Pereira, Claudio A., Pullen, Timothy J., Kabiri, Mostafa, Becker, Katja, Gull, Keith, Steverding, Dietmar

“…Adenylate kinases occur classically as cytoplasmic and mitochondrial enzymes, but the expression of seven adenylate kinases in the flagellated protozoan…”
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Distinct Molecular Signatures of Clinical Clusters in People With Type 2 Diabetes: An IMI-RHAPSODY Study by Slieker, Roderick C, Donnelly, Louise A, Fitipaldi, Hugo, Bouland, Gerard A, Giordano, Giuseppe N, Åkerlund, Mikael, Gerl, Mathias J, Ahlqvist, Emma, Ali, Ashfaq, Dragan, Iulian, Elders, Petra, Festa, Andreas, Hansen, Michael K, van der Heijden, Amber A, Mansour Aly, Dina, Kim, Min, Kuznetsov, Dmitry, Mehl, Florence, Klose, Christian, Simons, Kai, Pavo, Imre, Pullen, Timothy J, Suvitaival, Tommi, Wretlind, Asger, Rossing, Peter, Lyssenko, Valeriya, Legido Quigley, Cristina, Groop, Leif, Thorens, Bernard, Franks, Paul W, Ibberson, Mark, Rutter, Guy A, Beulens, Joline W J, 't Hart, Leen M, Pearson, Ewan R

“…Type 2 diabetes is a multifactorial disease with multiple underlying aetiologies. To address this heterogeneity, investigators of a previous study clustered…”
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ADCY5 Couples Glucose to Insulin Secretion in Human Islets by HODSON, David J, MITCHELL, Ryan K, LAVALLARD, Vanessa, BOSCO, Domenico, PIEMONTI, Lorenzo, JOHNSON, Paul R, HUGHES, Stephen J, DALIANG LI, LI, Wen-Hong, SHAPIRO, A. M. James, RUTTER, Guy A, MARSELLI, Lorella, PULLEN, Timothy J, BRIAS, Silvia Gimeno, SEMPLICI, Francesca, EVERETT, Katy L, COOPER, Dermot M. F, BUGLIANI, Marco, MARCHETTI, Piero

“…Single nucleotide polymorphisms (SNPs) within the ADCY5 gene, encoding adenylate cyclase 5, are associated with elevated fasting glucose and increased type 2…”
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Overexpression of Monocarboxylate Transporter-1 (Slc16a1) in Mouse Pancreatic β-cells Leads to Relative Hyperinsulinism During Exercise by PULLEN, Timothy J, SYLOW, Lykke, GAO SUN, HALESTRAP, Andrew P, RICHTER, Erik A, RUTTER, Guy A

“…Exercise-induced hyperinsulinism (EIHI) is an autosomal dominant disorder characterized by inappropriate insulin secretion in response to vigorous physical…”
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Chronic Activation of γ2 AMPK Induces Obesity and Reduces β Cell Function by Yavari, Arash, Stocker, Claire J., Ghaffari, Sahar, Wargent, Edward T., Steeples, Violetta, Czibik, Gabor, Pinter, Katalin, Bellahcene, Mohamed, Woods, Angela, Martínez de Morentin, Pablo B., Cansell, Céline, Lam, Brian Y.H., Chuster, André, Petkevicius, Kasparas, Nguyen-Tu, Marie-Sophie, Martinez-Sanchez, Aida, Pullen, Timothy J., Oliver, Peter L., Stockenhuber, Alexander, Nguyen, Chinh, Lazdam, Merzaka, O’Dowd, Jacqueline F., Harikumar, Parvathy, Tóth, Mónika, Beall, Craig, Kyriakou, Theodosios, Parnis, Julia, Sarma, Dhruv, Katritsis, George, Wortmann, Diana D.J., Harper, Andrew R., Brown, Laurence A., Willows, Robin, Gandra, Silvia, Poncio, Victor, de Oliveira Figueiredo, Márcio J., Qi, Nathan R., Peirson, Stuart N., McCrimmon, Rory J., Gereben, Balázs, Tretter, László, Fekete, Csaba, Redwood, Charles, Yeo, Giles S.H., Heisler, Lora K., Rutter, Guy A., Smith, Mark A., Withers, Dominic J., Carling, David, Sternick, Eduardo B., Arch, Jonathan R.S., Cawthorne, Michael A., Watkins, Hugh, Ashrafian, Houman

“…Despite significant advances in our understanding of the biology determining systemic energy homeostasis, the treatment of obesity remains a medical challenge…”
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