Search Results - "Pullen, Steven S."

Urinary Exosomal miRNA Signature in Type II Diabetic Nephropathy Patients by Delić, Denis, Eisele, Claudia, Schmid, Ramona, Baum, Patrick, Wiech, Franziska, Gerl, Martin, Zimdahl, Heike, Pullen, Steven S, Urquhart, Richard

“…MicroRNAs (miRNAs) are short non-coding RNA species which are important post-transcriptional regulators of gene expression and play an important role in the…”
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Transgenic expression of human APOL1 risk variants in podocytes induces kidney disease in mice by Beckerman, Pazit, Bi-Karchin, Jing, Park, Ae Seo Deok, Qiu, Chengxiang, Dummer, Patrick D, Soomro, Irfana, Boustany-Kari, Carine M, Pullen, Steven S, Miner, Jeffrey H, Hu, Chien-An A, Rohacs, Tibor, Inoue, Kazunori, Ishibe, Shuta, Saleem, Moin A, Palmer, Matthew B, Cuervo, Ana Maria, Kopp, Jeffrey B, Susztak, Katalin

“…Risk variants of APOL1 associated with human chronic kidney disease have been identified, but causality has been unclear. Transgenic expression in mice now…”
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The key role of NLRP3 and STING in APOL1-associated podocytopathy by Wu, Junnan, Raman, Archana, Coffey, Nathan J, Sheng, Xin, Wahba, Joseph, Seasock, Matthew J, Ma, Ziyuan, Beckerman, Pazit, Laczkó, Dorottya, Palmer, Matthew B, Kopp, Jeffrey B, Kuo, Jay J, Pullen, Steven S, Boustany-Kari, Carine M, Linkermann, Andreas, Susztak, Katalin

“…Coding variants in apolipoprotein L1 (APOL1), termed G1 and G2, can explain most excess kidney disease risk in African Americans; however, the molecular…”
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Mapping the genetic architecture of human traits to cell types in the kidney identifies mechanisms of disease and potential treatments by Sheng, Xin, Guan, Yuting, Ma, Ziyuan, Wu, Junnan, Liu, Hongbo, Qiu, Chengxiang, Vitale, Steven, Miao, Zhen, Seasock, Matthew J., Palmer, Matthew, Shin, Myung K., Duffin, Kevin L., Pullen, Steven S., Edwards, Todd L., Hellwege, Jacklyn N., Hung, Adriana M., Li, Mingyao, Voight, Benjamin F., Coffman, Thomas M., Brown, Christopher D., Susztak, Katalin

“…The functional interpretation of genome-wide association studies (GWAS) is challenging due to the cell-type-dependent influences of genetic variants. Here, we…”
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In vivo selective inhibition of TRPC6 by antagonist BI 749327 ameliorates fibrosis and dysfunction in cardiac and renal disease by Lin, Brian Leei, Matera, Damian, Doerner, Julia F., Zheng, Nan, del Camino, Donato, Mishra, Sumita, Bian, Hong, Zeveleva, Svetlana, Zhen, Xiaoguang, Blair, Nathaniel T., Chong, Jayhong A., Hessler, David P., Bedja, Djahida, Zhu, Guangshuo, Muller, Grace K., Ranek, Mark J., Pantages, Lynn, McFarland, Mary, Netherton, Matthew R., Berry, Angela, Wong, Diane, Rast, Georg, Qian, Hu Sheng, Weldon, Steven M., Kuo, Jay J., Sauer, Achim, Sarko, Chris, Moran, Magdalene M., Kass, David A., Pullen, Steven S.

“…Transient receptor potential canonical type 6 (TRPC6) is a non-selective receptor-operated cation channel that regulates reactive fibrosis and growth…”
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Deep learning-based quantification of NAFLD/NASH progression in human liver biopsies by Heinemann, Fabian, Gross, Peter, Zeveleva, Svetlana, Qian, Hu Sheng, Hill, Jon, Höfer, Anne, Jonigk, Danny, Diehl, Anna Mae, Abdelmalek, Manal, Lenter, Martin C., Pullen, Steven S., Guarnieri, Paolo, Stierstorfer, Birgit

“…Non-alcoholic fatty liver disease (NAFLD) affects about 24% of the world's population. Progression of early stages of NAFLD can lead to the more advanced form…”
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Pharmacological TRPC6 inhibition improves survival and muscle function in mice with Duchenne muscular dystrophy by Lin, Brian L, Shin, Joseph Y, Jeffreys, William Pd, Wang, Nadan, Lukban, Clarisse A, Moorer, Megan C, Velarde, Esteban, Hanselman, Olivia A, Kwon, Seoyoung, Kannan, Suraj, Riddle, Ryan C, Ward, Christopher W, Pullen, Steven S, Filareto, Antonio, Kass, David A

“…Gene mutations causing loss of dystrophin result in the severe muscle disease known as Duchenne muscular dystrophy (DMD). Despite efforts at genetic repair,…”
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Discovery of Potent, Selective Chymase Inhibitors via Fragment Linking Strategies by Taylor, Steven J, Padyana, Anil K, Abeywardane, Asitha, Liang, Shuang, Hao, Ming-Hong, De Lombaert, Stéphane, Proudfoot, John, Farmer, Bennett S, Li, Xiang, Collins, Brandon, Martin, Leslie, Albaugh, Daniel R, Hill-Drzewi, Melissa, Pullen, Steven S, Takahashi, Hidenori

“…Chymase plays an important and diverse role in the homeostasis of a number of cardiovascular processes. Herein, we describe the identification of potent,…”
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Modulation of vascular contraction via soluble guanylate cyclase signaling in a novel ex vivo method using rat precision‐cut liver slices by Oldenburger, Anouk, Birk, Gerald, Schlepütz, Marco, Broermann, Andre, Stierstorfer, Birgit, Pullen, Steven S., Rippmann, Jörg F.

“…Fibrotic processes in the liver of non‐alcoholic steatohepatitis (NASH) patients cause microcirculatory dysfunction in the organ which increases blood vessel…”
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Renal compartment–specific genetic variation analyses identify new pathways in chronic kidney disease by Qiu, Chengxiang, Huang, Shizheng, Park, Jihwan, Park, YoSon, Ko, Yi-An, Seasock, Matthew J., Bryer, Joshua S., Xu, Xiang-Xi, Song, Wen-Chao, Palmer, Matthew, Hill, Jon, Guarnieri, Paolo, Hawkins, Julie, Boustany-Kari, Carine M., Pullen, Steven S., Brown, Christopher D., Susztak, Katalin

“…Chronic kidney disease (CKD), a condition in which the kidneys are unable to clear waste products, affects 700 million people globally. Genome-wide association…”
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Three mechanistically distinct kinase assays compared: Measurement of intrinsic ATPase activity identified the most comprehensive set of ITK inhibitors by Kashem, Mohammed A, Nelson, Richard M, Yingling, Jeffrey D, Pullen, Steven S, Prokopowicz, 3rd, Anthony S, Jones, Jessi Wildeson, Wolak, John P, Rogers, George R, Morelock, Maurice M, Snow, Roger J, Homon, Carol Ann, Jakes, Scott

“…Numerous assay methods have been developed to identify small-molecule effectors of protein kinases, but no single method can be applied to all isolated…”
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The senescence-associated secretome of Hedgehog-deficient hepatocytes drives MASLD progression by Jun, Ji Hye, Du, Kuo, Dutta, Rajesh Kumar, Maeso-Diaz, Raquel, Oh, Seh Hoon, Wang, Liuyang, Gao, Guannan, Ferreira, Ana, Hill, Jon, Pullen, Steven S, Diehl, Anna Mae

“…The burden of senescent hepatocytes correlates with the severity of metabolic dysfunction-associated steatotic liver disease (MASLD), but the mechanisms…”
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The CD40-TRAF6 axis controls affinity maturation and the generation of long-lived plasma cells by Noelle, Randolph J, Ahonen, Cory L, Manning, Eric M, Erickson, Loren D, O'Connor, Brian P, Lind, Evan F, Pullen, Steven S, Kehry, Marilyn R

“…Affinity maturation of the immune response and the generation of long-lived bone marrow (BM) plasma cells are hallmarks of CD40-dependent, thymus-dependent…”
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Crystallographic Analysis of CD40 Recognition and Signaling by Human TRAF2 by McWhirter, Sarah M., Pullen, Steven S., Holton, James M., Crute, James J., Kehry, Marilyn R., Alber, Tom

“…Tumor necrosis factor receptor superfamily members convey signals that promote diverse cellular responses. Receptor trimerization by extracellular ligands…”
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CD40−Tumor Necrosis Factor Receptor-Associated Factor (TRAF) Interactions:  Regulation of CD40 Signaling through Multiple TRAF Binding Sites and TRAF Hetero-Oligomerization by Pullen, Steven S, Miller, Heather G, Everdeen, Daniel S, Dang, Thu T. A, Crute, James J, Kehry, Marilyn R

“…CD40 is a TNF receptor superfamily member that provides activation signals in antigen-presenting cells such as B cells, macrophages, and dendritic cells…”
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Itk kinase inhibitors: Initial efforts to improve the metabolical stability and the cell activity of the benzimidazole lead by Moriarty, Kevin J., Winters, Michael, Qiao, Lei, Ryan, Declan, DesJarlis, Renee, Robinson, Darius, Cook, Brian N., Kashem, Mohammed A., Kaplita, Paul V., Liu, Lisa H., Farrell, Thomas M., Khine, Hnin Hnin, King, Josephine, Pullen, Steven S., Roth, Gregory P., Magolda, Ronald, Takahashi, Hidenori

“…The SAR study and metabolically stabilized benzimidazole class Itk inhibitors is discussed. Previously, we reported a series of novel benzimidazole based Itk…”
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The Novel, Clinical-Stage Soluble Guanylate Cyclase Activator BI 685509 Protects from Disease Progression in Models of Renal Injury and Disease by Reinhart, Glenn A, Harrison, Paul C, Lincoln, Kathleen, Chen, Hongxing, Sun, Peng, Hill, Jon, Qian, Hu Sheng, McHugh, Mark C, Clifford, Holly, Ng, Khing Jow, Wang, Hong, Fowler, Danielle, Gueneva-Boucheva, Kristina, Brenneman, Jehrod B, Bosanac, Todd, Wong, Diane, Fryer, Ryan M, Sarko, Chris, Boustany-Kari, Carine M, Pullen, Steven S

“…Activation of soluble guanylate cyclase (sGC) to restore cyclic guanosine monophosphate (cGMP) and improve functionality of nitric oxide (NO) pathways impaired…”
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Single-cell multi-omic and spatial profiling of human kidneys implicates the fibrotic microenvironment in kidney disease progression by Abedini, Amin, Levinsohn, Jonathan, Klötzer, Konstantin A., Dumoulin, Bernhard, Ma, Ziyuan, Frederick, Julia, Dhillon, Poonam, Balzer, Michael S., Shrestha, Rojesh, Liu, Hongbo, Vitale, Steven, Bergeson, Andi M., Devalaraja-Narashimha, Kishor, Grandi, Paola, Bhattacharyya, Tanmoy, Hu, Erding, Pullen, Steven S., Boustany-Kari, Carine M., Guarnieri, Paolo, Karihaloo, Anil, Traum, Daniel, Yan, Hanying, Coleman, Kyle, Palmer, Matthew, Sarov-Blat, Lea, Morton, Lori, Hunter, Christopher A., Kaestner, Klaus H., Li, Mingyao, Susztak, Katalin

“…Kidneys are intricate three-dimensional structures in the body, yet the spatial and molecular principles of kidney health and disease remain inadequately…”
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High-Affinity Interactions of Tumor Necrosis Factor Receptor-Associated Factors (TRAFs) and CD40 Require TRAF Trimerization and CD40 Multimerization by Pullen, Steven S, Labadia, Mark E, Ingraham, Richard H, McWhirter, Sarah M, Everdeen, Daniel S, Alber, Tom, Crute, James J, Kehry, Marilyn R

“…Signaling by some TNF receptor family members, including CD40, is mediated by TNF receptor-associated factors (TRAFs) that interact with receptor cytoplasmic…”
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A Soluble Guanylate Cyclase Activator Inhibits the Progression of Diabetic Nephropathy in the ZSF1 Rat by Boustany-Kari, Carine M, Harrison, Paul C, Chen, Hongxing, Lincoln, Kathleen A, Qian, Hu Sheng, Clifford, Holly, Wang, Hong, Zhang, Xiaomei, Gueneva-Boucheva, Kristina, Bosanac, Todd, Wong, Diane, Fryer, Ryan M, Richman, Jeremy G, Sarko, Chris, Pullen, Steven S

“…Therapies that restore renal cGMP levels are hypothesized to slow the progression of diabetic nephropathy. We investigated the effect of BI 703704, a soluble…”
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