Search Results - "Pullambhatla, Mrudula"
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2-(3-{1-Carboxy-5-[(6-[18F]Fluoro-Pyridine-3-Carbonyl)-Amino]-Pentyl}-Ureido)-Pentanedioic Acid, [18F]DCFPyL, a PSMA-Based PET Imaging Agent for Prostate Cancer
Published in Clinical cancer research (15-12-2011)“…We have synthesized and evaluated in vivo 2-(3-{1-carboxy-5-[(6-[(18)F]fluoro-pyridine-3-carbonyl)-amino]-pentyl}-ureido)-pentanedioic acid, [(18)F]DCFPyL, as…”
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A low molecular weight PSMA-based fluorescent imaging agent for cancer
Published in Biochemical and biophysical research communications (18-12-2009)“…We synthesized YC-27 3 to provide a fluorescent imaging agent for the prostate-specific membrane antigen (PSMA), a marker for hormone-independent prostate…”
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Synthesis and Biological Evaluation of Low Molecular Weight Fluorescent Imaging Agents for the Prostate-Specific Membrane Antigen
Published in Bioconjugate chemistry (19-12-2012)“…Targeted near-infrared (NIR) optical imaging can be used in vivo to detect specific tissues, including malignant cells. A series of NIR fluorescent ligands…”
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Radiohalogenated Prostate-Specific Membrane Antigen (PSMA)-Based Ureas as Imaging Agents for Prostate Cancer
Published in Journal of medicinal chemistry (25-12-2008)“…To extend our development of new imaging agents targeting the prostate-specific membrane antigen (PSMA), we have used the versatile intermediate…”
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A modular strategy to prepare multivalent inhibitors of prostate-specific membrane antigen (PSMA)
Published in Oncotarget (01-12-2011)“…We have developed a modular scaffold for preparing high-affinity, homo-multivalent inhibitors of the prostate-specific membrane antigen (PSMA) for imaging and…”
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Influence of Bioluminescence Imaging Dynamics by D-Luciferin Uptake and Efflux Mechanisms
Published in Molecular imaging (01-11-2012)“…Bioluminescence imaging (BLI) detects light generated by luciferase-mediated oxidation of substrate and is used widely for evaluating transgene expression in…”
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Effect of Chelators on the Pharmacokinetics of 99mTc-Labeled Imaging Agents for the Prostate-Specific Membrane Antigen (PSMA)
Published in Journal of medicinal chemistry (22-07-2013)“…Technetium-99m, the most commonly used radionuclide in nuclear medicine, can be attached to biologically important molecules through a variety of chelating…”
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Synthesis and biological evaluation of substrate-based imaging agents for the prostate-specific membrane antigen
Published in Macromolecular research (01-05-2013)“…Prostate-specific membrane antigen (PSMA) is an attractive target for the imaging of prostate cancer (PCa) due to the elevated expression on the surface of…”
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68Ga-Labeled Inhibitors of Prostate-Specific Membrane Antigen (PSMA) for Imaging Prostate Cancer
Published in Journal of medicinal chemistry (22-07-2010)“…Gallium-68 is a generator-produced radionuclide for positron emission tomography (PET) that is being increasingly used for radiolabeling of tumor-targeting…”
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Standards and Guidelines for Validating Next-Generation Sequencing Bioinformatics Pipelines: A Joint Recommendation of the Association for Molecular Pathology and the College of American Pathologists
Published in The Journal of molecular diagnostics : JMD (01-01-2018)“…Bioinformatics pipelines are an integral component of next-generation sequencing (NGS). Processing raw sequence data to detect genomic alterations has…”
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Auger Radiopharmaceutical Therapy Targeting Prostate-Specific Membrane Antigen
Published in Journal of Nuclear Medicine (01-09-2015)“…Auger electron emitters such as (125)I have a high linear energy transfer and short range of emission (<10 μm), making them suitable for treating…”
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Assessments of Somatic Variant Classification Using the Association for Molecular Pathology/American Society of Clinical Oncology/College of American Pathologists Guidelines
Published in The Journal of molecular diagnostics : JMD (01-02-2023)“…To assess the clinical implementation of the 2017 Standards and Guidelines for the Interpretation and Reporting of Sequence Variants in Cancer: A Joint…”
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111 In- and IRDye800CW-Labeled PLA-PEG Nanoparticle for Imaging Prostate-Specific Membrane Antigen-Expressing Tissues
Published in Biomacromolecules (09-01-2017)“…Targeted delivery of drug-encapsulated nanoparticles is a promising new approach to safe and effective therapeutics for cancer. Here we investigate the…”
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Preclinical Comparative Study of (68)Ga-Labeled DOTA, NOTA, and HBED-CC Chelated Radiotracers for Targeting PSMA
Published in Bioconjugate chemistry (15-06-2016)“…(68)Ga-labeled, low-molecular-weight imaging agents that target the prostate-specific membrane antigen (PSMA) are increasingly used clinically to detect…”
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Cu-labeled inhibitors of prostate-specific membrane antigen for PET imaging of prostate cancer
Published in Journal of medicinal chemistry (27-03-2014)“…Prostate-specific membrane antigen (PSMA) is a well-recognized target for identification and therapy of a variety of cancers. Here we report five…”
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Clinical Significance of DNA Variants in Chronic Myeloid Neoplasms: A Report of the Association for Molecular Pathology
Published in The Journal of molecular diagnostics : JMD (01-11-2018)“…To address the clinical relevance of small DNA variants in chronic myeloid neoplasms (CMNs), an Association for Molecular Pathology Working Group…”
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Immunoimaging of CXCR4 Expression in Brain Tumor Xenografts Using SPECT/CT
Published in Journal of Nuclear Medicine (01-07-2009)“…Chemokine receptor 4 (CXCR4) is expressed in a variety of cancers, including breast, brain, ovarian, and prostate. CXCR4-CXCL12 interactions are critical for…”
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Synthesis and Evaluation of Gd III ‐Based Magnetic Resonance Contrast Agents for Molecular Imaging of Prostate‐Specific Membrane Antigen
Published in Angewandte Chemie International Edition (07-09-2015)“…Abstract Magnetic resonance (MR) imaging is advantageous because it concurrently provides anatomic, functional, and molecular information. MR molecular imaging…”
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Molecular Imaging of CXCR4 Receptor Expression in Human Cancer Xenografts with [64Cu]AMD3100 Positron Emission Tomography
Published in Cancer research (Chicago, Ill.) (15-05-2010)“…The chemokine receptor CXCR4 and its cognate ligand CXCL12 are pivotal for establishing metastases from many tumor types. Thus, CXCR4 may offer a cell surface…”
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Recommendations for Cell-Free DNA Assay Validations: A Joint Consensus Recommendation of the Association for Molecular Pathology and College of American Pathologists
Published in The Journal of molecular diagnostics : JMD (01-12-2023)“…Diagnosing, selecting therapy for, and monitoring cancer in patients using a minimally invasive blood test represents a significant advance in precision…”
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