Search Results - "Pulko, Vesna"

Dysregulated TGF-β Production Underlies the Age-Related Vulnerability to Chikungunya Virus by Uhrlaub, Jennifer L, Pulko, Vesna, DeFilippis, Victor R, Broeckel, Rebecca, Streblow, Daniel N, Coleman, Gary D, Park, Byung S, Lindo, John F, Vickers, Ivan, Anzinger, Joshua J, Nikolich-Žugich, Janko

“…Chikungunya virus (CHIKV) is a re-emerging global pathogen with pandemic potential, which causes fever, rash and debilitating arthralgia. Older adults over 65…”
Get full text

JAK and mTOR inhibitors prevent cytokine release while retaining T cell bispecific antibody in vivo efficacy by Leclercq, Gabrielle, Haegel, Hélène, Toso, Alberto, Zimmermann, Tina, Green, Luke, Steinhoff, Nathalie, Sam, Johannes, Pulko, Vesna, Schneider, Anneliese, Giusti, Anna Maria, Challier, John, Freimoser-Grundschober, Anne, Larivière, Laurent, Odermatt, Alex, Stern, Martin, Umana, Pablo, Bacac, Marina, Klein, Christian

“…BackgroundT cell engaging therapies, like chimeric antigen receptor T cells and T cell bispecific antibodies (TCBs), efficiently redirect T cells towards tumor…”
Get full text

Src/lck inhibitor dasatinib reversibly switches off cytokine release and T cell cytotoxicity following stimulation with T cell bispecific antibodies by Leclercq, Gabrielle, Haegel, Hélène, Schneider, Anneliese, Giusti, Anna Maria, Marrer-Berger, Estelle, Boetsch, Christophe, Walz, Antje-Christine, Pulko, Vesna, Sam, Johannes, Challier, John, Ferlini, Cristiano, Odermatt, Alex, Umaña, Pablo, Bacac, Marina, Klein, Christian

“…BackgroundT cell engagers are bispecific antibodies recognizing, with one moiety, the CD3ε chain of the T cell receptor and, with the other moiety, specific…”
Get full text

CAR-J cells for antibody discovery and lead optimization of TCR-like immunoglobulins by Jost, Christian, Darowski, Diana, Challier, John, Pulko, Vesna, Hanisch, Lydia J, Xu, Wei, Mössner, Ekkehard, Bujotzek, Alexander, Klostermann, Stefan, Umana, Pablo, Kontermann, Roland E, Klein, Christian

“…T-cell bispecific antibodies (TCBs) are a novel class of engineered immunoglobulins that unite monovalent binding to the T-cell receptor (TCR) CD3e chain and…”
Get full text

B7-H1 limits the entry of effector CD8+ T cells to the memory pool by upregulating Bim by Gibbons, Rachel M, Liu, Xin, Pulko, Vesna, Harrington, Susan M, Krco, Christopher J, Kwon, Eugene D, Dong, Haidong

“…Protective T-cell immunity against cancer and infections is dependent on the generation of a durable effector and memory T-cell pool. Studies from cancer and…”
Get full text

Dendritic cells dictate responses to PD-L1 blockade cancer immunotherapy by Mayoux, Maud, Roller, Andreas, Pulko, Vesna, Sammicheli, Stefano, Chen, Stanford, Sum, Eva, Jost, Christian, Fransen, Marieke F, Buser, Regula B, Kowanetz, Marcin, Rommel, Karolin, Matos, Ines, Colombetti, Sara, Belousov, Anton, Karanikas, Vaios, Ossendorp, Ferry, Hegde, Priti S, Chen, Daniel S, Umana, Pablo, Perro, Mario, Klein, Christian, Xu, Wei

“…PD-L1/PD-1 blocking antibodies have demonstrated therapeutic efficacy across a range of human cancers. Extending this benefit to a greater number of patients,…”
Get more information

Aging and cytomegalovirus infection differentially and jointly affect distinct circulating T cell subsets in humans by Wertheimer, Anne M, Bennett, Michael S, Park, Byung, Uhrlaub, Jennifer L, Martinez, Carmine, Pulko, Vesna, Currier, Noreen L, Nikolich-Žugich, Dragana, Kaye, Jeffrey, Nikolich-Žugich, Janko

“…The impact of intrinsic aging upon human peripheral blood T cell subsets remains incompletely quantified and understood. This impact must be distinguished from…”
Get full text

Human memory T cells with a naive phenotype accumulate with aging and respond to persistent viruses by Pulko, Vesna, Davies, John S, Martinez, Carmine, Lanteri, Marion C, Busch, Michael P, Diamond, Michael S, Knox, Kenneth, Bush, Erin C, Sims, Peter A, Sinari, Shripad, Billheimer, Dean, Haddad, Elias K, Murray, Kristy O, Wertheimer, Anne M, Nikolich-Žugich, Janko

“…Nikolich-Žugich and colleagues describe a unique subset of human T cells with a naive phenotype and the ability to rapidly produce cytokines in response to…”
Get full text

Targeting intracellular WT1 in AML with a novel RMF-peptide-MHC-specific T-cell bispecific antibody by Augsberger, Christian, Hänel, Gerulf, Xu, Wei, Pulko, Vesna, Hanisch, Lydia Jasmin, Augustin, Angelique, Challier, John, Hunt, Katharina, Vick, Binje, Rovatti, Pier Eduardo, Krupka, Christina, Rothe, Maurine, Schönle, Anne, Sam, Johannes, Lezan, Emmanuelle, Ducret, Axel, Ortiz-Franyuti, Daniela, Walz, Antje-Christine, Benz, Jörg, Bujotzek, Alexander, Lichtenegger, Felix S., Gassner, Christian, Carpy, Alejandro, Lyamichev, Victor, Patel, Jigar, Konstandin, Nikola, Tunger, Antje, Schmitz, Marc, von Bergwelt-Baildon, Michael, Spiekermann, Karsten, Vago, Luca, Jeremias, Irmela, Marrer-Berger, Estelle, Umaña, Pablo, Klein, Christian, Subklewe, Marion

“…Antibody-based immunotherapy is a promising strategy for targeting chemoresistant leukemic cells. However, classical antibody-based approaches are restricted…”
Get full text

Augmenting Efficacy of T-Cell Bispecific Antibodies in AML through a Tumor Stroma-Targeted 4-1BB Agonist by Hänel, Gerulf, Neumann, Anne-Sophie, Pulko, Vesna, Claus, Christina, Leutbecher, Alexandra, Marcinek, Anetta, Zieger, Nora, Buecklein, Veit L, Umana, Pablo, Klein, Christian, Subklewe, Marion

“…Bispecific antibodies represent a promising treatment option for acute myeloid leukemia (AML). We have recently described a novel T-cell bispecific antibody…”
Get full text

Role of Cell-Intrinsic and Environmental Age-Related Changes in Altered Maintenance of Murine T Cells in Lymphoid Organs by Davies, John S, Thompson, Heather L, Pulko, Vesna, Padilla Torres, Jose, Nikolich-Žugich, Janko

“…Age-related changes in primary lymphoid organs are well described. Less is known about age-related changes affecting peripheral lymphoid organs, although…”
Get full text

Heterochronic parabiosis: allowing the dissection of the aged immune system (LYM2P.723) by Davies, John, Pulko, Vesna, Thompson, Heather, Nikolich-Zugich, Janko

“…Abstract Parabiosis is the surgical union of two organisms resulting in the development of a single, shared circulatory system. When animals of different ages…”
Get full text

TLR3-Stimulated Dendritic Cells Up-regulate B7-H1 Expression and Influence the Magnitude of CD8 T Cell Responses to Tumor Vaccination by Pulko, Vesna, Liu, Xin, Krco, Christopher J, Harris, Kimberley J, Frigola, Xavier, Kwon, Eugene D, Dong, Haidong

“…Agonists of TLR have been explored as vaccine adjuvants for tumor immunotherapy. However, their immunological consequences are not fully understood. Although…”
Get full text

B7-h1 expressed by activated CD8 T cells is essential for their survival by Pulko, Vesna, Harris, Kimberley J, Liu, Xin, Gibbons, Rachel M, Harrington, Susan M, Krco, Christopher J, Kwon, Eugene D, Dong, Haidong

“…An immunoinhibitory role of B7 homologue 1 (B7-H1) expressed by non-T cells has been established; however, the function of B7-H1 expressed by T cells is not…”
Get full text

Abstract 3658: Dendritic cells dictate the responsiveness of PD-L1 blockade in cancer by Mayoux, Maud, Fransen, Marieke F., Roller, Andreas, Matos, Ines, Pulko, Vesna, Karanikas, Vaios, Umana, Pablo, Klein, Christian, Ossendorp, Ferry A., Xu, Wei

“…Abstract Recent advances in cancer immunotherapies with PD-1/PD-L1 pathway blockade have transformed the way that cancer is being treated, leading to durable…”
Get full text

Targeting Intracellular WT1 in AML Utilizing a T Cell Bispecific Antibody Construct: Augmenting Efficacy through Combination with Lenalidomide by Klein, Christian, Augsberger, Christian, Xu, Wei, Heitmüller, Christina, Hanisch, Lydia, Sam, Johannes, Pulko, Vesna, Schönle, Anne, Challier, John, Carpy, Alejandro, Konstandin, Nikola, Rothe, Maurine, Hänel, Gerulf, Bücklein, Veit, Lichtenegger, Felix S., Tunger, Antje, Schmitz, Marc, von Bergwelt, Michael, Spiekermann, Karsten, Umana, Pablo, Subklewe, Marion

“…Antibody-based immunotherapy represents a promising strategy to target chemo-resistant leukemic cells. However, current antibody-based approaches are…”
Get full text

653 Dasatinib as a rapid pharmacological ON/OFF switch for T cell bispecific antibody-induced T cell activation and cytokine release by Leclercq, Gabrielle, Haegel, Helene, Schneider, Anneliese, Berger, Estelle Marrer, Walz, Antje, Boetsch, Christophe, Pulko, Vesna, Ferlini, Cristiano, Klein, Christian

“…BackgroundT cell bispecific antibodies (TCBs) are extremely potent T cell engagers, harboring a 2+1 format with one binder to the CD3ε chain and two binders to…”
Get full text

Dysregulated TGF-[beta] Production Underlies the Age-Related Vulnerability to Chikungunya Virus by Uhrlaub, Jennifer L, Pulko, Vesna, DeFilippis, Victor R, Broeckel, Rebecca, Streblow, Daniel N, Coleman, Gary D, Park, Byung S, Lindo, John F, Vickers, Ivan, Anzinger, Joshua J, Nikolich-Zugich, Janko

“…Chikungunya virus (CHIKV) is a re-emerging global pathogen with pandemic potential, which causes fever, rash and debilitating arthralgia. Older adults over 65…”
Get full text

Aging and cytomegalovirus (CMV) infection differentially and jointly affect distinct circulating T cell subsets in humans1 by Wertheimer, Anne M., Bennett, Michael S., Park, Byung, Uhrlaub, Jennifer L., Martinez, Carmine, Pulko, Vesna, Currier, Noreen L., Nikolich-Zugich, Dragana, Kaye, Jeffrey, Nikolich-Zugich, Janko

“…The impact of intrinsic aging upon human peripheral blood T-cell subsets remains incompletely quantified and understood. This impact must be distinguished from…”
Get full text

T cell-intrinsic B7-homolog-1 (B7-H1) regulates effector CD8 T cell survival and memory cell generation (83.13) by Dong, Haidong, Pulko, Vesna, Liu, Xin, Harris, Kimberley

“…Abstract B7 homolog-1 ( B7-H1) expressed by antigen-presenting cells or tumor cells is a negative regulator of T cell responses, however its function on T…”
Get full text