Search Results - "Pulkkinen, Leena"

Gene expression of peripheral blood mononuclear cells as a tool in dietary intervention studies: What do we know so far? by de Mello, Vanessa Derenji Ferreira, Kolehmanien, Marjukka, Schwab, Ursula, Pulkkinen, Leena, Uusitupa, Matti

“…Peripheral blood mononuclear cells (PBMCs) generally refer to monocytes and lymphocytes, representing cells of the innate and adaptive immune systems. PBMCs…”
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DNA methylation in obesity and type 2 diabetes by de Mello, Vanessa Derenji Ferreira, Pulkkinen, Leena, Lalli, Marianne, Kolehmainen, Marjukka, Pihlajamäki, Jussi, Uusitupa, Matti

“…To elucidate the mechanisms related to the development of type 2 diabetes (T2D) and other degenerative diseases at a molecular level, a better understanding of…”
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Association of ADIPOQ gene variants with body weight, type 2 diabetes and serum adiponectin concentrations: the Finnish Diabetes Prevention Study by Siitonen, Niina, Pulkkinen, Leena, Lindström, Jaana, Kolehmainen, Marjukka, Eriksson, Johan G, Venojärvi, Mika, Ilanne-Parikka, Pirjo, Keinänen-Kiukaanniemi, Sirkka, Tuomilehto, Jaakko, Uusitupa, Matti

“…Adiponectin, secreted mainly by mature adipocytes, is a protein with insulin-sensitising and anti-atherogenic effects. Human adiponectin is encoded by the…”
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Targeted Ablation of the Abcc6 Gene Results in Ectopic Mineralization of Connective Tissues by Klement, John F., Matsuzaki, Yasushi, Jiang, Qiu-Jie, Terlizzi, Joseph, Choi, Hae Young, Fujimoto, Norihiro, Li, Kehua, Pulkkinen, Leena, Birk, David E., Sundberg, John P., Uitto, Jouni

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Mutation analysis and molecular genetics of epidermolysis bullosa by Pulkkinen, Leena, Uitto, Jouni

“…Cutaneous basement membrane zone (BMZ) consists of a number of attachment structures that are critical for stable association of the epidermis to the…”
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Tissue-Specific Expression of the ABCC6 Gene by Matsuzaki, Yasushi, Nakano, Aoi, Jiang, Qiu-Jie, Pulkkinen, Leena, Uitto, Jouni

“…The ABCC6 gene encodes MRP6, a member of the multidrug resistance-associated protein (MRP) family. Interest in ABCC6/MRP6 derives, in part, from the fact that…”
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Molecular genetics of pseudoxanthoma elasticum: a metabolic disorder at the environment–genome interface? by Uitto, Jouni, Pulkkinen, Leena, Ringpfeil, Franziska

“…Pseudoxanthoma elasticum (PXE) is a relatively rare heritable disorder affecting the skin, eyes and cardiovascular system, with considerable morbidity and…”
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Variation in the UCP2 and UCP3 genes associates with abdominal obesity and serum lipids: the Finnish Diabetes Prevention Study by Salopuro, Titta, Pulkkinen, Leena, Lindström, Jaana, Kolehmainen, Marjukka, Tolppanen, Anna-Maija, Eriksson, Johan G, Valle, Timo T, Aunola, Sirkka, Ilanne-Parikka, Pirjo, Keinänen-Kiukaanniemi, Sirkka, Tuomilehto, Jaakko, Laakso, Markku, Uusitupa, Matti

“…We explored the associations of three variants in the uncoupling protein 2 (UCP2) gene, one variant in the UCP2-UCP3 intergenic region and five variants in the…”
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Association of ADIPOR2 gene variants with cardiovascular disease and type 2 diabetes risk in individuals with impaired glucose tolerance: the Finnish Diabetes Prevention Study by Siitonen, Niina, Pulkkinen, Leena, Lindström, Jaana, Kolehmainen, Marjukka, Schwab, Ursula, Eriksson, Johan G, Ilanne-Parikka, Pirjo, Keinänen-Kiukaanniemi, Sirkka, Tuomilehto, Jaakko, Uusitupa, Matti

“…Adiponectin is an adipokine with insulin-sensitising and anti-atherogenic effects. Two receptors for adiponectin, ADIPOR1 and ADIPOR2, have been characterized…”
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Variations in the ghrelin receptor gene associate with obesity and glucose metabolism in individuals with impaired glucose tolerance by Mager, Ursula, Degenhardt, Tatjana, Pulkkinen, Leena, Kolehmainen, Marjukka, Tolppanen, Anna-Maija, Lindström, Jaana, Eriksson, Johan G, Carlberg, Carsten, Tuomilehto, Jaakko, Uusitupa, Matti

“…Ghrelin may influence the development of obesity through its role in the control of energy balance, food intake, and regulation of body weight. The effects of…”
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Targeted Inactivation of Murine Laminin γ2-Chain Gene Recapitulates Human Junctional Epidermolysis Bullosa by Meng, Xianmin, Klement, John F., Leperi, Dominic A., Birk, David E., Sasaki, Takako, Timpl, Rupert, Uitto, Jouni, Pulkkinen, Leena

“…Junctional forms of epidermolysis bullosa (JEB) are associated with mutations in six distinct genes expressed in the cutaneous basement membrane zone; these…”
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Laminin 5 mutations in junctional epidermolysis bullosa: molecular basis of Herlitz vs non-Herlitz phenotypes by NAKANO, Aoi, CHAO, Sheau-Chiou, PULKKINEN, Leena, MURRELL, Dedee, BRUCKNER-TUDERMAN, Leena, PFENDNER, Ellen, UITTO, Jouni

“…Junctional epidermolysis bullosa (JEB) is a group of heritable blistering diseases in which tissue separation occurs within the lamina lucida of the cutaneous…”
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Revertant Mosaicism in Epidermolysis Bullosa Caused by Mitotic Gene Conversion by Jonkman, Marcel F, Scheffer, Hans, Stulp, Rein, Pas, Hendri H, Nijenhuis, Miranda, Heeres, Klaas, Owaribe, Katsushi, Pulkkinen, Leena, Uitto, Jouni

“…Mitotic gene conversion acting as reverse mutation has not been previously demonstrated in human. We report here that the revertant mosaicism of a compound…”
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Compound Heterozygosity for a Recurrent 16.5-kb Alu-Mediated Deletion Mutation and Single-Base-Pair Substitutions in the ABCC6 Gene Results in Pseudoxanthoma Elasticum by Ringpfeil, Franziska, Nakano, Aoi, Uitto, Jouni, Pulkkinen, Leena

“…Pseudoxanthoma elasticum (PXE) is a systemic heritable disorder affecting the elastic structures in the skin, eyes, and cardiovascular system, with…”
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Identification of ABCC6 pseudogenes on human chromosome 16p : implications for mutation detection in pseudoxanthoma elasticum by PULKKINEN, Leena, NAKANO, Aoi, RINGPFEIL, Franziska, UITTO, Jouni

“…Pseudoxanthoma elasticum (PXE), a heritable disorder affecting the skin, eyes, and the cardiovascular system, has recently been linked to mutations in the…”
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Prenatal diagnosis for Epidermolysis bullosa: a study of 144 consecutive pregnancies at risk by Pfendner, Ellen G., Nakano, Aoi, Pulkkinen, Leena, Christiano, Angela M., Uitto, Jouni

“…Epidermolysis bullosa (EB) is a group of inherited disorders characterized by increased skin fragility, resulting in blisters and erosions after minor trauma…”
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Gene Expression of FTO in Human Subcutaneous Adipose Tissue, Peripheral Blood Mononuclear Cells and Adipocyte Cell Line by Lappalainen, Tiina, Kolehmainen, Marjukka, Schwab, Ursula, Pulkkinen, Leena, de Mello, Vanessa D.F., Vaittinen, Maija, Laaksonen, David E., Poutanen, Kaisa, Uusitupa, Matti, Gylling, Helena

“…Background/Aims: The common polymorphism rs9939609 of the fat mass and obesity-associated gene (FTO) is strongly associated with obesity, but the biological…”
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Herlitz's junctional epidermolysis bullosa is linked to mutations in the gene (LAMC2) for the γ2 subunit of nicein/kalinin (LAMININ-5) by Aberdam, Daniel, Christiano, Angela M, Galliano, Marie-Florence, Vailly, Joëlle, Meneguzzi, Guerrino, Tryggvason, Karl, Pulkkinen, Leena, Epstein, Ervin H, Uitto, Jouni, Ortonne, Jean-Paul, Bonifas, Jeannette

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Mutations in the γ2 chain gene (LAMC2) of kalinin/laminin 5 in the junctional forms of epidermolysis bullosa by Pulkkinen, Leena, Christiano, Angela M, Airenne, Tomi, Haakana, Heli, Tryggvason, Karl, Uitto, Jouni

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Ghrelin in Diabetes and Metabolic Syndrome by Uusitupa, Matti, Kolehmainen, Marjukka, Ukkola, Olavi, Pulkkinen, Leena

“…Metabolic syndrome is a cluster of related risk factors for cardiovascular disease, type 2 diabetes and liver disease. Obesity, which has become a global…”
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