A short and concise route to total synthesis of Dendrodolide L

[Display omitted] •Dendrodolide L is a 12 membered secondary metabolite, which was isolated by from dendrochium sp.•It exhibits in vitro cytotoxicity against the tumour cell line HCT-116 with an IC50 value of 26.5 Lµg/mL.•It is a short and efficient approach for stereoselective synthesis of Dendrodo...

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Bibliographic Details
Published in:	Tetrahedron letters Vol. 58; no. 24; pp. 2344 - 2346
Main Authors:	Regalla, Venkata Reddy, Addada, RamaKrishnam Raju, Puli, Venkat Swami, Saxena, Abhishek S., Chatterjee, Anindita
Format:	Journal Article
Language:	English
Published:	Elsevier Ltd 14-06-2017
Subjects:	1,3-Dithiane Jacobsen kinetic resolution Ozonolysis Regioselective ring-opening of epoxide Yamaguchi macrolactonisation Ozonolysis Jacobsen kinetic resolution Regioselective ring-opening of epoxide Yamaguchi macrolactonisation 1,3-Dithiane
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Summary:	[Display omitted] •Dendrodolide L is a 12 membered secondary metabolite, which was isolated by from dendrochium sp.•It exhibits in vitro cytotoxicity against the tumour cell line HCT-116 with an IC50 value of 26.5 Lµg/mL.•It is a short and efficient approach for stereoselective synthesis of Dendrodolide L.•Jacobson kinetic resolution, regioselective ring-opening of epoxide and Yamaguchi macrolactonization as key steps. A short and efficient method for the stereoselective synthesis of Dendrodolide L has been developed from inexpensive and commercially available starting material. This convergent synthesis utilizes Jacobsen kinetic resolution, regioselective ring-opening of epoxide and Yamaguchi macrolactonization as key steps.
ISSN:	0040-4039 1873-3581
DOI:	10.1016/j.tetlet.2017.04.097