Search Results - "Pujol‐Borrell, R."

Comparative study of clinical grade human tolerogenic dendritic cells by Naranjo-Gómez, M, Raïch-Regué, D, Oñate, C, Grau-López, L, Ramo-Tello, C, Pujol-Borrell, R, Martínez-Cáceres, E, Borràs, Francesc E

“…The use of tolerogenic DCs is a promising therapeutic strategy for transplantation and autoimmune disorders. Immunomodulatory DCs are primarily generated from…”
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Genetics of Graves' Disease: Special Focus on the Role of TSHR Gene by Pujol-Borrell, R, Giménez-Barcons, M, Marín-Sánchez, A, Colobran, R

“…As most autoimmune diseases, inherited predisposition to Graves' disease (GD) is polygenic with the main contributory genes being located in the HLA region…”
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Gene expression profiles for the human pancreas and purified islets in Type 1 diabetes: new findings at clinical onset and in long-standing diabetes by Planas, R, Carrillo, J, Sanchez, A, Ruiz de Villa, M.C, Nuñez, F, Verdaguer, J, James, R.F.L, Pujol-Borrell, R, Vives-Pi, M

“…Type 1 diabetes (T1D) is caused by the selective destruction of the insulin-producing β cells of the pancreas by an autoimmune response. Due to ethical and…”
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Dendritic cells pulsed with antigen-specific apoptotic bodies prevent experimental type 1 diabetes by Marin-Gallen, S, Clemente-Casares, X, Planas, R, Pujol-Autonell, I, Carrascal, J, Carrillo, J, Ampudia, R, Verdaguer, J, Pujol-Borrell, R, Borràs, F.E, Vives-Pi, M

“…Dendritic cells (DCs) are powerful antigen-presenting cells capable of maintaining peripheral tolerance. The possibility to generate tolerogenic DCs opens new…”
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The chemokine network. I. How the genomic organization of chemokines contains clues for deciphering their functional complexity by Colobran, R., Pujol‐Borrell, R., Armengol, Ma P., Juan, M.

“…Summary Chemokines are a superfamily of small structurally related cytokines that have evolved to form a complex network of proteins that typically regulate…”
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chemokine network. II. On how polymorphisms and alternative splicing increase the number of molecular species and configure intricate patterns of disease susceptibility by Colobran, R, Pujol-Borrell, R, Armengol, M.P, Juan, M

“…In this second review on chemokines, we focus on the polymorphisms and alternative splicings and on their consequences in disease. Because chemokines are key…”
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Evidence of expression of endotoxin receptors CD14, toll‐like receptors TLR4 and TLR2 and associated molecule MD‐2 and of sensitivity to endotoxin (LPS) in islet beta cells by VIVES‐PI, M., SOMOZA, N., FERNÁNDEZ‐ALVAREZ, J., VARGAS, F., CARO, P., ALBA, A., GOMIS, R., LABETA, M. O., PUJOL‐BORRELL, R.

“…SUMMARY CD14, a GPI‐linked membrane protein, is a component of the lipopolysaccharide (LPS) receptor complex, one of the pattern‐recognizing receptors (PRR)…”
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Natural killer cells are required for accelerated type 1 diabetes driven by interferon-β by Alba, A, Planas, R, Clemente, X, Carrillo, J, Ampudia, R, Puertas, M.-C, Pastor, X, Tolosa, E, Pujol-Borrell, R, Verdaguer, J, Vives-Pi, M

“…The destruction of β cells by the islet infiltrating lymphocytes causes type 1 diabetes. Transgenic mice models expressing interferon (IFN)-β in β cells, in…”
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Influx of recent thymic emigrants into autoimmune thyroid disease glands in humans by Armengol, M.P, Sabater, L, Fernández, M, Ruíz, M, Alonso, N, Otero, M.J, Martínez-Cáceres, E, Jaraquemada, D, Pujol-Borrell, R

“…Autoimmune thyroid diseases (AITD) are considered as prototypic organ-specific autoimmune diseases, yet their underlying aetiology remains poorly understood…”
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Specific T-cell proliferation to myelin peptides in relapsing-remitting multiple sclerosis by Grau-Lopez, L, Raich, D, Ramo-Tello, C, Naranjo-Gomez, M, Davalos, A, Pujol-Borrell, R, Borras, F E, Martinez-Caceres, E

“…Background:  The identification of major immunogenic peptides in multiple sclerosis (MS) is of great importance for the development of antigen‐specific…”
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Primary Alloproliferative TH1 Response Induced by Immature Plasmacytoid Dendritic Cells in Collaboration with Myeloid DCs by Naranjo‐Gómez, M., Fernández, M.A., Bofill, M., Singh, R., Navarrete, C.V., Pujol‐Borrell, R., Borràs, F.E.

“…The role played by dendritic cell (DC) subsets in the immune response to alloantigens is not well defined. In vitro experiments have extensively shown that…”
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Statin-associated autoimmune myopathy: A distinct new IFL pattern can increase the rate of HMGCR antibody detection by clinical laboratories by Alvarado-Cardenas, M, Marin, A, Martínez, MA, Martínez, L, Pinal-Fernandez, I, Labrador-Horrillo, M, Balada, E, Mundet-Tuduri, X, Gonzalez-Mera, L, Casademont, J, Acebes, E Martínez, Moreno, PJ, Juarez, C, Grau-Junyent, JM, Pujol-Borrell, R, Selva-O'Callaghan, A

“…Abstract Background and objective Statin-associated autoimmune myopathy (SAAM) with anti-HMGCR antibodies has recently been described. Several specific…”
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Engraftment of islets obtained by collagenase and Liberase in diabetic rats: A comparative study by VARGAS, F, JULIAN, J. F, LLAMAZARES, J. F, GARCIA-CUYAS, F, JIMENEZ, M, PUJOL-BORRELL, R, VIVES-PI, M

“…Islet transplantation is an attractive solution for type I diabetes, but the results are at the present discouraging. Collagenase, the enzyme used to obtain…”
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Novel and atypical splicing mutation in a compound heterozygous UNC13D defect presenting in Familial Hemophagocytic Lymphohistiocytosis triggered by EBV infection by Alsina, L, Colobran, R, de Sevilla, M.F, Català, A, Viñas, L, Ricart, S, Plaza, A.M, Lois, S, Juan, M, Pujol-Borrell, R, Martinez-Gallo, M

“…Abstract Familial Hemophagocytic Lymphohistiocytosis type 3 (FHL3) is a genetic disorder caused by mutations in UNC13D gene, coding the granule priming factor…”
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Overexpression of Metallothionein I/II: A New Feature of Thyroid Follicular Cells in Graves' Disease by Ruiz-Riol, M, Martínez-Arconada, M. J, Alonso, N, Soldevila, B, Marchena, D, Armengol, M. P, Sanmartí, A, Pujol-Borrell, R, Martínez-Cáceres, E. M

“…Context: One salient feature of autoimmune thyroid disease is the inappropriate expression of human leukocyte antigen (HLA) class II molecules by thyroid…”
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Reg (regenerating) gene overexpression in islets from non-obese diabetic mice with accelerated diabetes: role of IFNβ by Planas, R, Alba, A, Carrillo, J, Puertas, M. C, Ampudia, R, Pastor, X, Okamoto, H, Takasawa, S, Gurr, W, Pujol-Borrell, R, Verdaguer, J, Vives-Pi, M

“…Aims/hypothesis The expression of IFNβ in beta cells results in accelerated type 1 diabetes. The REG family of beta cell proliferation factors have been…”
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Myelin peptides in multiple sclerosis by Grau-López, L, Raïch, D, Ramo-Tello, C, Naranjo-Gómez, M, Dàvalos, A, Pujol-Borrell, R, Borràs, F.E, Martínez-Cáceres, E

“…Abstract The development of specific therapies for organ-specific autoimmune diseases requires the identification of relevant immunogenic epitopes, recognized…”
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Copy number variation in the CCL4L gene is associated with susceptibility to acute rejection in lung transplantation by Colobran, R, Casamitjana, N, Roman, A, Faner, R, Pedrosa, E, Arostegui, J I, Pujol-Borrell, R, Juan, M, Palou, E

“…Lung transplantation (LT) has become an accepted therapy for selected patients with advanced lung disease. One of the main limitations to successful LT is…”
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Population structure in copy number variation and SNPs in the CCL4L chemokine gene by Colobran, R, Comas, D, Faner, R, Pedrosa, E, Anglada, R, Pujol-Borrell, R, Bertranpetit, J, Juan, M

“…The recent description of a large amount of copy number variation (CNV) in the human genome has extended the concept of genome diversity. In this study we…”
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HLA-DQ2/DQ8 and HLA-DQB102 homozygosity typing by real-time polymerase chain reaction for the assessment of celiac disease genetic risk: evaluation of a Spanish celiac population by Ruiz-Ortiz, E., Montraveta, M., Cabré, E., Herrero-Mata, M. J., Pujol-Borrell, R., Palou, E., Faner, R.

“…Celiac disease (CD) is a complex autoimmune disorder caused by ingestion of gluten in genetically susceptible individuals. Different genetic risk factors have…”
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