Search Results - "Pui Y. Lee"

Monogenic autoinflammatory disorders: Conceptual overview, phenotype, and clinical approach by Nigrovic, Peter A, Lee, Pui Y, Hoffman, Hal M

“…Autoinflammatory diseases are conditions in which pathogenic inflammation arises primarily through antigen-independent hyperactivation of immune pathways…”
Get full text

Vasculopathy, Immunodeficiency, and Bone Marrow Failure: The Intriguing Syndrome Caused by Deficiency of Adenosine Deaminase 2 by Lee, Pui Y

“…Deficiency of adenosine deaminase 2 (DADA2) is a monogenic form of systemic vasculopathy that often presents during early childhood. Linked to biallelic…”
Get full text

On the Alert for Cytokine Storm: Immunopathology in COVID‐19 by Henderson, Lauren A., Canna, Scott W., Schulert, Grant S., Volpi, Stefano, Lee, Pui Y., Kernan, Kate F., Caricchio, Roberto, Mahmud, Shawn, Hazen, Melissa M., Halyabar, Olha, Hoyt, Kacie J., Han, Joseph, Grom, Alexei A., Gattorno, Marco, Ravelli, Angelo, Benedetti, Fabrizio, Behrens, Edward M., Cron, Randy Q., Nigrovic, Peter A.

“…Poor outcomes in COVID‐19 correlate with clinical and laboratory features of cytokine storm syndrome. Broad screening for cytokine storm and early, targeted…”
Get full text

At the Heart of Treating Kawasaki Disease: The Search for New Approaches to Prevent Coronary Artery Aneurysms by Du, Yan, Lee, Pui Y.

Get full text

Ly6 family proteins in neutrophil biology by Lee, Pui Y., Wang, Jun‐Xia, Parisini, Emilio, Dascher, Christopher C., Nigrovic, Peter A.

“…Review of the structure, expression, and function of members of the Ly6 gene family, with a focus on their role in neutrophil biology. The murine Ly6 complex…”
Get full text

Distinct clinical and immunological features of SARS-CoV-2-induced multisystem inflammatory syndrome in children by Lee, Pui Y, Day-Lewis, Megan, Henderson, Lauren A, Friedman, Kevin G, Lo, Jeffrey, Roberts, Jordan E, Lo, Mindy S, Platt, Craig D, Chou, Janet, Hoyt, Kacie J, Baker, Annette L, Banzon, Tina M, Chang, Margaret H, Cohen, Ezra, de Ferranti, Sarah D, Dionne, Audrey, Habiballah, Saddiq, Halyabar, Olha, Hausmann, Jonathan S, Hazen, Melissa M, Janssen, Erin, Meidan, Esra, Nelson, Ryan W, Nguyen, Alan A, Sundel, Robert P, Dedeoglu, Fatma, Nigrovic, Peter A, Newburger, Jane W, Son, Mary Beth F

“…BACKGROUNDPediatric SARS-CoV-2 infection can be complicated by a dangerous hyperinflammatory condition termed multisystem inflammatory syndrome in children…”
Get full text

A dominant autoinflammatory disease caused by non-cleavable variants of RIPK1 by Tao, Panfeng, Sun, Jinqiao, Wu, Zheming, Wang, Shihao, Wang, Jun, Li, Wanjin, Pan, Heling, Bai, Renkui, Zhang, Jiahui, Wang, Ying, Lee, Pui Y., Ying, Wenjing, Zhou, Qinhua, Hou, Jia, Wang, Wenjie, Sun, Bijun, Yang, Mi, Liu, Danru, Fang, Ran, Han, Huan, Yang, Zhaohui, Huang, Xin, Li, Haibo, Deuitch, Natalie, Zhang, Yuan, Dissanayake, Dilan, Haude, Katrina, McWalter, Kirsty, Roadhouse, Chelsea, MacKenzie, Jennifer J., Laxer, Ronald M., Aksentijevich, Ivona, Yu, Xiaomin, Wang, Xiaochuan, Yuan, Junying, Zhou, Qing

“…Activation of RIPK1 controls TNF-mediated apoptosis, necroptosis and inflammatory pathways 1 . Cleavage of human and mouse RIPK1 after residues D324 and D325,…”
Get full text

Genotype and functional correlates of disease phenotype in deficiency of adenosine deaminase 2 (DADA2) by Lee, Pui Y., Kellner, Erinn S., Huang, Yuelong, Furutani, Elissa, Huang, Zhengping, Bainter, Wayne, Alosaimi, Mohammed F., Stafstrom, Kelsey, Platt, Craig D., Stauber, Tali, Raz, Somech, Tirosh, Irit, Weiss, Aaron, Jordan, Michael B., Krupski, Christa, Eleftheriou, Despina, Brogan, Paul, Sobh, Ali, Baz, Zeina, Lefranc, Gerard, Irani, Carla, Kilic, Sara S., El-Owaidy, Rasha, Lokeshwar, M.R., Pimpale, Pallavi, Khubchandani, Raju, Chambers, Eugene P., Chou, Janet, Geha, Raif S., Nigrovic, Peter A., Zhou, Qing

“…Deficiency of adenosine deaminase 2 (DADA2) is a syndrome with pleiotropic manifestations including vasculitis and hematologic compromise. A systematic…”
Get full text

Induction of autoimmunity by pristane and other naturally occurring hydrocarbons by Reeves, Westley H, Lee, Pui Y, Weinstein, Jason S, Satoh, Minoru, Lu, Li

“…Tetramethylpentadecane (TMPD, or commonly known as pristane)-induced lupus is a murine model of systemic lupus erythematosus (SLE). Renal disease and…”
Get full text

Identification of Distinct Inflammatory Programs and Biomarkers in Systemic Juvenile Idiopathic Arthritis and Related Lung Disease by Serum Proteome Analysis by Chen, Guangbo, Deutsch, Gail H., Schulert, Grant S., Zheng, Hong, Jang, SoRi, Trapnell, Bruce, Lee, Pui Y., Macaubas, Claudia, Ho, Katherine, Schneider, Corinne, Saper, Vivian E., Jesus, Adriana Almeida, Krasnow, Mark A., Grom, Alexei, Goldbach‐Mansky, Raphaela, Khatri, Purvesh, Mellins, Elizabeth D., Canna, Scott W.

“…Objective Recent observations in systemic juvenile idiopathic arthritis (JIA) suggest an increasing incidence of high‐mortality interstitial lung disease often…”
Get full text

Adenosine deaminase 2 as a biomarker of macrophage activation syndrome in systemic juvenile idiopathic arthritis by Lee, Pui Y, Schulert, Grant S, Canna, Scott W, Huang, Yuelong, Sundel, Jacob, Li, Ying, Hoyt, Kacie J, Blaustein, Rachel B, Wactor, Alexandra, Do, Thuy, Halyabar, Olha, Chang, Margaret H, Dedeoglu, Fatma, Case, Siobhan M, Meidan, Esra, Lo, Mindy S, Sundel, Robert P, Richardson, Edward T, Newburger, Jane W, Hershfield, Michael S, Son, Mary Beth, Henderson, Lauren A, Nigrovic, Peter A

“…Macrophage activation syndrome (MAS) is a life-threatening complication of systemic juvenile idiopathic arthritis (sJIA) characterised by a vicious cycle of…”
Get more information

Differential Responsiveness of Monocyte and Macrophage Subsets to Interferon by Han, Shuhong, Zhuang, Haoyang, Lee, Pui Y., Li, Mingjia, Yang, Lijun, Nigrovic, Peter A., Reeves, Westley H.

“…Objective Peripheral blood mononuclear cells (PBMCs) in systemic lupus erythematosus (SLE) patients exhibit a gene expression program (interferon [IFN]…”
Get full text

Megakaryocyte emperipolesis mediates membrane transfer from intracytoplasmic neutrophils to platelets by Cunin, Pierre, Bouslama, Rim, Machlus, Kellie R, Martínez-Bonet, Marta, Lee, Pui Y, Wactor, Alexandra, Nelson-Maney, Nathan, Morris, Allyn, Guo, Li, Weyrich, Andrew, Sola-Visner, Martha, Boilard, Eric, Italiano, Joseph E, Nigrovic, Peter A

“…Bone marrow megakaryocytes engulf neutrophils in a phenomenon termed emperipolesis. We show here that emperipolesis is a dynamic process mediated actively by…”
Get full text

Editorial: DADA2 and other monogenic vasculitides by Lee, Pui Y, Batu, Ezgi D, Ozen, Seza

Get full text

Interstitial Lung Disease and Psoriasis in a Child With Aicardi-Goutières Syndrome by Zheng, Shaoling, Lee, Pui Y, Wang, Jun, Wang, Shihao, Huang, Qidang, Huang, Yukai, Liu, Yuqi, Zhou, Qing, Li, Tianwang

“…Aicardi-Goutières syndrome (AGS) is characterized by progressive neurologic decline, cerebral calcification, and variable manifestations of autoimmunity. Seven…”
Get full text

Pathogenesis of Diffuse Alveolar Hemorrhage in Murine Lupus by Zhuang, Haoyang, Han, Shuhong, Lee, Pui Y., Khaybullin, Ravil, Shumyak, Stepan, Lu, Li, Chatha, Amina, Afaneh, Anan, Zhang, Yuan, Xie, Chao, Nacionales, Dina, Moldawer, Lyle, Qi, Xin, Yang, Li‐Jun, Reeves, Westley H.

“…Objective Diffuse alveolar hemorrhage (DAH) in lupus patients confers >50% mortality, and the cause is unknown. We undertook this study to examine the…”
Get full text

Ferroptosis of CD163+ tissue-infiltrating macrophages and CD10+ PC+ epithelial cells in lupus nephritis by Cheng, Qi, Mou, Lijun, Su, Wenjing, Chen, Xin, Zhang, Ting, Xie, Yifan, Xue, Jing, Lee, Pui Y., Wu, Huaxiang, Du, Yan

“…Background Dysregulation of cell death and defective clearance of dying cells are closely related to the pathogenesis of lupus nephritis (LN). However, the…”
Get full text

B cells enhance early innate immune responses during bacterial sepsis by Kelly-Scumpia, Kindra M, Scumpia, Philip O, Weinstein, Jason S, Delano, Matthew J, Cuenca, Alex G, Nacionales, Dina C, Wynn, James L, Lee, Pui Y, Kumagai, Yutaro, Efron, Philip A, Akira, Shizuo, Wasserfall, Clive, Atkinson, Mark A, Moldawer, Lyle L

“…Microbes activate pattern recognition receptors to initiate adaptive immunity. T cells affect early innate inflammatory responses to viral infection, but both…”
Get full text

Type I interferon signature and cycling lymphocytes in macrophage activation syndrome by Huang, Zhengping, Brodeur, Kailey E, Chen, Liang, Du, Yan, Wobma, Holly, Hsu, Evan E, Liu, Meng, Chang, Joyce C, Chang, Margaret H, Chou, Janet, Day-Lewis, Megan, Dedeoglu, Fatma, Halyabar, Olha, Lederer, James A, Li, Tianwang, Lo, Mindy S, Lu, Meiping, Meidan, Esra, Newburger, Jane W, Randolph, Adrienne G, Son, Mary Beth, Sundel, Robert P, Taylor, Maria L, Wu, Huaxiang, Zhou, Qing, Canna, Scott W, Wei, Kevin, Henderson, Lauren A, Nigrovic, Peter A, Lee, Pui Y

“…BACKGROUNDMacrophage activation syndrome (MAS) is a life-threatening complication of Still's disease (SD) characterized by overt immune cell activation and…”
Get full text

Monocyte and Macrophage Abnormalities in Systemic Lupus Erythematosus by Li, Yi, Lee, Pui Y, Reeves, Westley H

“…Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with profound effects on multiple organ systems. In patients with SLE, the immune system is…”
Get full text