Search Results - "Puglisi, J L"

LabHEART: an interactive computer model of rabbit ventricular myocyte ion channels and Ca transport by Puglisi, J L, Bers, D M

“…An interactive computer program, LabHEART, was developed to simulate the action potential (AP), ionic currents, and Ca handling mechanisms in a rabbit…”
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Temperature and relative contributions of Ca transport systems in cardiac myocyte relaxation by Puglisi, J L, Bassani, R A, Bassani, J W, Amin, J N, Bers, D M

“…The relative contributions of the different Ca transport systems involved in cardiac relaxation were evaluated at 25 and 35 degrees C in isolated rabbit,…”
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Kinematic analysis of a novel 2-d.o.f. orientation device by Serracín, J.R., Puglisi, L.J., Saltaren, R., Ejarque, G., Sabater-Navarro, J.M., Aracil, R.

“…This paper presents the development of a new parallel robot designed for helping with bone milling surgeries. The robot is a small modular wrist with 2 active…”
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Ca(2+) influx through Ca(2+) channels in rabbit ventricular myocytes during action potential clamp: influence of temperature by Puglisi, J L, Yuan, W, Bassani, J W, Bers, D M

“…Ca(2+) influx via Ca(2+) current (I(Ca)) during the action potential (AP) was determined at 25 degrees C and 35 degrees C in isolated rabbit ventricular…”
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Myosin heavy chain gene expression in neonatal rat heart cells: effects of [Ca2+]i and contractile activity by Qi, M, Puglisi, J L, Byron, K L, Ojamaa, K, Klein, I, Bers, D M, Samarel, A M

“…To determine if mechanical signals or alterations in intracellular Ca2+ concentration ([Ca2+]i) affect myosin heavy chain (MHC) gene expression in…”
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Role of the Sarcoplasmic Reticulum in Contraction and Relaxation of Immature Rabbit Ventricular Myocytes by Balaguru, Duraisamy, Haddock, Peter S., Puglisi, Jośe L., Bers, Donald M., Coetzee, William A., Artman, Michael

“…Previous indirect studies of newborn hearts have suggested a diminished functional role of the SR and a greater dependency upon trans-sarcolemmal Ca2+fluxes to…”
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Modelling calcium microdomains using homogenisation by Higgins, Erin R., Goel, Pranay, Puglisi, Jose L., Bers, Donald M., Cannell, Mark, Sneyd, James

“…Microdomains of calcium (i.e., areas on the nanometer scale that have qualitatively different calcium concentrations from that in the bulk cytosol) are known…”
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Proarrhythmic Consequences of a KCNQ1 AKAP-Binding Domain Mutation: Computational Models of Whole Cells and Heterogeneous Tissue by Saucerman, Jeffrey J, Healy, Sarah N, Belik, Mary E, Puglisi, Jose L, McCulloch, Andrew D

“…The KCNQ1-G589D gene mutation, associated with a long-QT syndrome, has been shown to disrupt yotiao-mediated targeting of protein kinase A and protein…”
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Modeling the isolated cardiac myocyte by Puglisi, Jose L., Wang, Fei, Bers, Donald M.

“…Computer modeling of cardiac myocytes has flourished in recent years. Models have evolved from mathematical descriptions of ionic channels alone to more…”
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Action potential duration determines sarcoplasmic reticulum Ca2+ reloading in mammalian ventricular myocytes by Bassani, Rosana A., Altamirano, Julio, Puglisi, José L., Bers, Donald M.

“…After sarcoplasmic reticulum (SR) Ca 2+ depletion in intact ventricular myocytes, electrical activity promotes SR Ca 2+ reloading and recovery of twitch…”
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Myosin heavy chain turnover in cultured neonatal rat heart cells: effects of [Ca2+]i and contractile activity by Byron, K L, Puglisi, J L, Holda, J R, Eble, D, Samarel, A M

“…Blockade of L-type Ca2+ channels in spontaneously contracting cultured neonatal rat ventricular myocytes causes contractile arrest, myofibrillar disassembly,…”
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Compound mutations in Long QT syndrome assessed by a computer model by Grandi, E., Puglisi, J.L., Bers, D., Severi, S.

“…Long QT syndrome (LQTS) is an electrical disorder that predisposes affected individuals to sudden death from cardiac arrhythmias. It has been shown that…”
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