Search Results - "Pugh, W John"

The application of Gaussian processes in the prediction of percutaneous absorption by Moss, Gary P., Sun, Yi, Prapopoulou, Maria, Davey, Neil, Adams, Rod, Pugh, W. John, Brown, Marc B.

“…Objectives The aim was to assess mathematically the nature of a skin permeability dataset and to determine the utility of Gaussian processes in developing a…”
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Formulation and characterization of a captopril ethyl ester drug-in-adhesive-type patch for percutaneous absorption by Gullick, Darren R., Pugh, W. John, Ingram, Matthew J., Cox, Paul A., Moss, Gary P.

“…Background: The ethyl ester of captopril has been shown to exhibit enhanced permeation across human skin compared to the parent drug. A drug-in-adhesive patch…”
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Metabolism of captopril carboxyl ester derivatives for percutaneous absorption by Gullick, Darren R., Ingram, Matthew J., Pugh, W. John, Cox, Paul A., Gard, Paul, Smart, John D., Moss, Gary P.

“…Objectives To determine the metabolism of captopril n‐carboxyl derivatives and how this may impact on their use as transdermal prodrugs. The pharmacological…”
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The application of Gaussian processes in the prediction of percutaneous absorption by Moss, Gary P, Sun, Yi, Prapopoulou, Maria, Davey, Neil, Adams, Rod, Pugh, W John, Brown, Marc B

“…OBJECTIVESThe aim was to assess mathematically the nature of a skin permeability dataset and to determine the utility of Gaussian processes in developing a…”
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Simple rules defining the potential of compounds for transdermal delivery or toxicity by Magnusson, Beatrice M, Pugh, W John, Roberts, Michael S

“…Simple rules based on readily accessible physicochemical properties enable identification of solutes that penetrate skin very slowly or rapidly. Literature in…”
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Design, synthesis and characterization of captopril prodrugs for enhanced percutaneous absorption by Moss, Gary P., Gullick, Darren R., Cox, Paul A., Alexander, Cameron, Ingram, Matthew J., Smart, John D., Pugh, W. John

“…Most drugs are designed primarily for oral administration, but the activity and stability profiles desirable for this route often make them unsuitable for…”
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Effect of vehicle pretreatment on the flux, retention, and diffusion of topically applied penetrants in vitro by Rosado, Catarina, Cross, Sheree E, Pugh, W John, Roberts, Michael S, Hadgraft, Jonathan

“…The flux of a topically applied drug depends on the activity in the skin and the interaction between the vehicle and skin. Permeation of vehicle into the skin…”
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Transdermal delivery enhancement of haloperidol from gel formulations by 1,8-cineole by Elgorashi, Abubakr S., Heard, Charles M., Niazy, Esmail M., Noureldin, Osman H., Pugh, W. John

“…The feasibility of using 10% 1,8‐cineole as an enhancer for transdermal delivery of haloperidol has been examined. In‐vitro transdermal delivery across…”
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Physico-chemical determinants of dermal drug delivery: effects of the number and substitution pattern of polar groups by du Plessis, Jeanetta, Pugh, W.John, Judefeind, Anja, Hadgraft, Jonathan

“…The aim of this study was to investigate the effect of number and substitution pattern of –OH groups of a set of phenols on the in vitro permeation of…”
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Probing the effect of vehicles on topical delivery : Understanding the basic relationship between solvent and solute penetration using silicone membranes by CROSS, Sheree E, PUGH, W. John, HADGRAFT, Jonathan, ROBERTS, Michael S

“…In the present study we examined the relationship between solvent uptake into a model membrane (silicone) with the physical properties of the solvents (e.g.,…”
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The effect of the nature of H-bonding groups on diffusion through PDMS membranes saturated with octanol and toluene by Du Plessis, Jeanetta, Pugh, W.John, Judefeind, Anja, Hadgraft, Jonathan

“…The permeation of a series of structurally related compounds across silicone membranes (PDMS) was studied. The PDMS was saturated either with toluene, to mimic…”
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Medication prescribing and administration in nursing homes by ROBERTS, MICHAEL S., KING, MICHELLE, STOKES, JULIE A., LYNNE, TERESA A., BONNER, CHRISTOPHER J., MCCARTHY, SEAN, WILSON, ANDREW, GLASZIOU, PAUL, PUGH, W. JOHN

“…Objective: to examine the key determinants of pharmaco-epidemiology in Australian nursing homes. Design: a cross-sectional survey of medication use in 998…”
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Epidermal permeability–penetrant structure relationships: 4, QSAR of permeant diffusion across human stratum corneum in terms of molecular weight, H-bonding and electronic charge by Pugh, W.John, Degim, I.Tuncer, Hadgraft, Jonathan

“…Principal components analysis (PCA) and multivariate regression analysis (MRA) are used to assess the predictors of permeant diffusion across human stratum…”
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The selection and design of topical and transdermal agents: a review by Hadgraft, J, Pugh, W J

“…One of the major problems in topical and transdermal drug delivery is the efficiency of the barrier property of the stratum corneum. Topical and transdermal…”
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Skin permeability data: anomalous results by Degim, I.Tuncer, Pugh, W.John, Hadgraft, Jonathan

“…Analysis of published skin permeation data has shown that a few compounds appear to have anomalous skin permeability coefficients. These include penetrants…”
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Mechanisms of action of skin penetration enhancers/retarders: Azone and analogues by Hadgraft, Jonathan, Peck, James, Williams, Dafydd G., Pugh, W.John, Allan, Geoffrey

“…The modifying effect of Azone and five analogues on diffusion of metronidazole through isolated stratum corneum (SC) is reported. All enhance diffusion except…”
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The micellar weights of the series dioctyl-to-didodecyl phosphatidylcholine by Pugh, W J, Saunders, L

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The effect of hydrogen bonding on diffusion across model membranes: consideration of the number of H-bonding groups by Du Plessis, Jeanetta, Pugh, W.John, Judefeind, Anja, Hadgraft, Jonathan

“…The diffusion of a series of phenols across simple silicone membranes impregnated with either octanol or toluene was studied. These solvents are taken up and…”
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A more perfect union by SEE, Saw-Teen, PUGH, W. John, PARKINSON, Adrian G

“…Established to promote greater public understanding of the United States Constitution, the National Constitution Center facility in Philadelphia is a structure…”
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Effect of ion complexants on the iontophoresis of salbutamol by Degim, I.Tuncer, Pugh, W.John, Hadgraft, Jonathan

“…Small inorganic ions in transdermal systems can competitively reduce the iontophoretic delivery of the target drug. Crown ether sequesters Na + and its…”
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